Dnyanopasak College

Parbhani, India

Dnyanopasak College

Parbhani, India

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Khobragade C.N.,Swami Ramanand Teerth Marathwada University | Bodade R.G.,Swami Ramanand Teerth Marathwada University | Konda S.G.,Yeshwant Mahavidyalaya | Dawane B.S.,Yeshwant Mahavidyalaya | Manwar A.V.,Dnyanopasak College
European Journal of Medicinal Chemistry | Year: 2010

Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives have been prepared by cyclocondensation of ethyl 2-cyano-3,3-bis(methylthio)prop-2-enoate with 2-amino-4-(substitutedphenyl)thiazole to give 3-cyano-2-methylthio-4-oxo-4H-6-(substitutedphenyl)thiazolo[3,2-a]pyrimidin (2a-j) and further reacting with hydrazine hydrate to yield the target compounds (3a-j). The chemical structure of the compounds was confirmed by IR and 1H NMR spectral data. All the compounds of the series have been screened for their antibacterial and antifungal activity studies. The result revealed that all compounds showed significant antimicrobial activity. © 2010 Elsevier Masson SAS. All rights reserved.


Goswami S.V.,Dnyanopasak College | Thorat P.B.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Tetrahedron Letters | Year: 2012

An efficient synthesis of dicycloalkenopyridines was achieved via one-pot three-component condensation of aromatic aldehyde, cyclohexanone, and hydroxylamine hydrochloride using 3-nitrophenylboronic acid as an efficient catalyst under ambient condition. The current methodology offers several advantages such as high yields (78-90%) and simple experimental work-up at ambient temperature conditions. © 2012 Elsevier Ltd. All rights reserved.


Thorat P.B.,Dnyanopasak College | Goswami S.V.,Dnyanopasak College | Jadhav W.N.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Australian Journal of Chemistry | Year: 2013

We report an enantioselective Henry (nitroaldol) reaction catalysed by an organocatalyst using water as solvent. The enantioselective synthesis of β-nitroalcohols was achieved by using a neutral chiral organocatalyst, through strong hydrogen bonding, which results in the formation of corresponding products in excellent yield and enantioselectivity at room temperature. Other attractive features of the method are the eco-friendly, non-hazardous, and mild reaction conditions, inexpensive catalyst, and simple work up conditions. © 2013 CSIRO.


Goswami S.V.,Dnyanopasak College | Thorat P.B.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Heterocyclic Communications | Year: 2012

A simple, inexpensive and efficient one-pot synthesis of piperidine derivatives was achieved in excellent yield via the three-component reaction of substituted aniline, 1,3-dicarbonyl compound and aromatic aldehyde using phenylboronic acid as catalyst.


Goswami S.V.,Dnyanopasak College | Thorat P.B.,Dnyanopasak College | Chakrawar A.V.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Molecular Diversity | Year: 2013

We have developed an efficient protocol for the synthesis of β-amino carbonyl compounds using phenylboronic acid as effective and eco-friendly catalyst via one-pot three-component Mannich reaction. Excellent yields, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method, which makes it a useful protocol for the synthesis of β-amino carbonyl compounds. © 2013 Springer Science+Business Media Dordrecht.


Patil J.U.,Dnyanopasak College | Biradar S.D.,Dnyanopasak College
Indian Journal of Natural Products and Resources | Year: 2011

The present paper deals with the study of plants used for ethnomedicinal purposes. Ethnomedicinal data of 30 species belonging to 29 genera of 25 families were collected from rustic people as well as tribes residing and practicing in various areas of Hingoli forest in Maharashtra. The study has brought to light lesser known potential ethno-medicinal plants of therapeutic value to cure various diseases.


Dake S.A.,Dnyanopasak College | Raut D.S.,Dnyanopasak College | Kharat K.R.,Deogiri College | Mhaske R.S.,Deogiri College | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

Ionic liquid ethyl ammonium nitrate is used as an excellent catalyst and solvent for three-component one-pot reaction of an aldehydes, amines and diethylphosphite to form novel α-aminophosphonates at room temperature. Among the various catalysts, the preparation of ethyl ammonium nitrate is an environmental friendly, cost effective and recyclable catalyst. Compounds 4b, 4c, 4d, 4f and 4j were found more potent antibacterials against pathogenic microorganisms. Whereas, compounds 4a, 4g, 4h and 4j inhibits growth of active Escherichia coli NCIM 2645 and Salmonella typhi NCIM 2501. Compound 4j was found a promising antiproliferative agent against A549 and SK-MEL2 human melanoma cell lines. © 2011 Elsevier Ltd. All rights reserved.


Thorat P.B.,Dnyanopasak College | Goswami S.V.,Dnyanopasak College | Khade B.C.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Tetrahedron Asymmetry | Year: 2012

A convenient protocol has been developed for the synthesis of Baylis-Hillman adducts in the presence of a base and an organocatalyst. We have designed and synthesized organocatalysts based on hydrogen bonding using a pyrrolidine ring as the backbone and applied them to Baylis-Hillman transformations. This method provides products in good to high yields (73-90%) and with excellent enantiomeric excesses (up to 96%) and reasonable reaction times.© 2012 Elsevier Ltd. All rights reserved.


Thorat P.B.,Dnyanopasak College | Goswami S.V.,Dnyanopasak College | Magar R.L.,Dnyanopasak College | Patil B.R.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
European Journal of Organic Chemistry | Year: 2013

This present method deals with an exceedingly rare aspect of α-aminophosphonate synthesis. We studied an enantioseletive one-pot synthetic method for the syntheses of optically active α-aminophosphonates by employing an organocatalyst. Some new organocatalysts were synthesized and studied for their reactivity and enantioselectivity. The organocatalyst effectively catalyzed the reaction and provided the corresponding α-aminophosphonates in high yields (71-90 %) with excellent enantiomeric excess values (73-92 %). The present method for the asymmetric synthesis of α-aminophosphonates through a direct organocatalytic one-pot procedure is described. The application of newly prepared organocatalysts to the syntheses of α-aminophosphonates was studied. This method provides wonderful yields for a wide range of α-aminophosphonates with high enantioselectivities under mild conditions at room temperature. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Thorat P.B.,Dnyanopasak College | Goswami S.V.,Dnyanopasak College | Khade B.C.,Dnyanopasak College | Bhusare S.R.,Dnyanopasak College
Tetrahedron Letters | Year: 2012

Using hydrogen bond based concept we have synthesized new organocatalysts and have applied them to catalyze direct asymmetric aldol reaction. Reaction proceeded efficiently and gave high yield with excellent diastereoselectivity and enantioselectivity. © 2012 Elsevier Ltd. All rights reserved.

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