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Cambridge, United Kingdom

Hall R.J.,Institute of Environmental Science and Research | Draper J.L.,National Center for Biosecurity and Infectious Disease | Nielsen F.G.,DNAdigest | Dutilh B.E.,University Utrecht | And 2 more authors.
Frontiers in Microbiology | Year: 2015

Powered by recent advances in next-generation sequencing technologies, metagenomics has already unveiled vast microbial biodiversity in a range of environments, and is increasingly being applied in clinics for difficult-to-diagnose cases. It can be tempting to suggest that metagenomics could be used as a "universal test" for all pathogens without the need to conduct lengthy serial testing using specific assays. While this is an exciting prospect, there are issues that need to be addressed before metagenomic methods can be applied with rigor as a diagnostic tool, including the potential for incidental findings, unforeseen consequences for trade and regulatory authorities, privacy and cultural issues, data sharing, and appropriate reporting of results to end-users. These issues will require consideration and discussion across a range of disciplines, with inclusion of scientists, ethicists, clinicians, diagnosticians, health practitioners, and ultimately the public. Here, we provide a primer for consideration on some of these issues. © 2015 Hall, Draper, Nielsen and Dutilh.

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This year, DNAdigest will be a media parnter for BioData World Congress again. There are two events this year one in the US and one in the UK ...

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The Young Alliance Against Cancer recently interviewed Fiona Nielsen CEO and founder of DNAdigest and Repositive. The interview was originally published at the website of the Young Alliance Against Cancer (YAAC) and is reposted with permission ...

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What is the genomic revolution? The genomic revolution is the change in healthcare and research that has been enabled by the development of DNA sequencing technologies and the sequencing of the human reference genome. The technologies for genome sequencing allow for identification and characterisation of genetic diseases based on genome sequence which again allows treatment to be personalised to the level of the individual genomic makeup of an individual ...

The genomics revolution is already here The techniques for researching and characterising genetic diseases are available to both researchers (next generation DNA sequencing) and the general public (in the form of personal testing), so we should soon be able to diagnose any genetic disease by sequencing a patients DNA. This is the ultimate goal of research into all genetic diseases, including into hereditary diseases and cancer ...

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