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DNA Diagnostics Center

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The mission of HomeDNA is to empower consumers with valuable information contained in their own DNA. Whether exploring family ancestry, taking the guesswork out of skincare, discovering ways to achieve a healthy weight, or determining the father of a child, these affordable genetic tests deliver the answers. HomeDNA provides three key benefits: "For the first time ever, consumers can choose from an assortment of DNA tests that interest them and buy the kits at their local drugstore" said Connie Hallquist, DDC's CEO. "It's exciting that cutting-edge science is so accessible and the process is so easy--consumers collect their DNA at home with a simple cheek swab, send to our lab for processing, then receive their custom report online." The HomeDNA selection currently includes four products: Skin Care, Healthy Weight, Ancestry, and Paternity. HomeDNA™ Skin Care Analysis + Report:  A revolutionary DNA test that examines 28 genes influencing skin's appearance. This genetic analysis helps consumers discover effective ingredients and treatments in these key cosmetic areas: collagen quality, skin elasticity, fine lines and wrinkles, sun protection, pigmentation, skin antioxidants, and skin sensitivity. HomeDNA™ Healthy Weight Analysis + Report: Developed by doctors, this lifestyle test examines genetic markers associated with weight management. The scientifically based program delivers specific diet and exercise strategies tailored to the consumer's DNA helping to take the guesswork out of how to achieve and maintain a healthy weight. HomeDNA™ Ancestry Analysis + Report: Consumers have the option to choose one of two tests:  The Advanced DNA Test combines the latest genetic research with a breakthrough ancestral tracking technique to pinpoint—often to a town or village--where the consumer's DNA was located 1,000 or more years ago and how it migrated over time. The Starter DNA Test determines more recent ancestral origins and matches the consumer's DNA to modern populations. HomeDNA™ Paternity Analysis + Report: Fast, accurate, and confidential answers for paternity questions. The kit is designed to collect DNA from one possible father + the child + the mother (her participation is optional, but recommended). Results, available in just one day from receipt of sample at the lab, can be used for peace-of-mind purposes, but also used for Court if consumers contact DDC ahead of time for a scheduled sample collection. Genetics play a big role in how we look and feel, but it's important to remember that other factors also influence outcomes. The skin and weight DNA tests are informational, and are not intended to be diagnostic or alter a consumer's medical care. Ab DNA Diagnostics Center (DDC®) is one of the world's largest private DNA testing companies with offices in Fairfield, Ohio and London, England. Since 1995, DDC® has expertly handled over 10 million DNA samples from 168 countries offering tests for paternity, immigration, and other family relationships; ancestry; health and beauty; forensics, and genetic traits of animals. DDC's accredited ISO 17025 laboratory uses state-of-the-art technology, robotics, and bioinformatics to ensure high quality results, and is certified by CLIA, CAP, AABB, NATA, and the Ministry of Justice. Visit www.DNACenter.com for more information.


News Article | December 2, 2016
Site: www.prnewswire.com

FAIRFIELD, Ohio, Dec. 2, 2016 /PRNewswire/ -- DNA Diagnostics Center® (DDC® or the Company), one of the world's largest private DNA testing companies, announces the acquisition of IDENTIGENE® LLC, a wholly-owned subsidiary of Sorenson Genomics, LLC. Details of the transaction were not...


Pradhan B.B.,DNA Diagnostics Center | Chatterjee S.,DNA Diagnostics Center
Molecular Microbiology | Year: 2014

Summary: Bacteria co-ordinate their social behaviour in a density-dependent manner by production of diffusible signal molecules by a process known as quorum sensing (QS). It is generally assumed that in homogenous environments and at high cell density, QS synchronizes cells in the population to perform collective social tasks in unison which maximize the benefit at the inclusive fitness of individuals. However, evolutionary theory predicts that maintaining phenotypic heterogeneity in performing social tasks is advantageous as it can serve as a bet-hedging survival strategy. Using Pseudomonas syringae and Xanthomonas campestris as model organisms, which use two diverse classes of QS signals, we show that two distinct subpopulations of QS-responsive and non-responsive cells exist in the QS-activated population. Addition of excess exogenous QS signal does not significantly alter the distribution of QS-responsive and non-responsive cells in the population. We further show that progeny of cells derived from these subpopulations also exhibited heterogeneous distribution patterns similar to their respective parental strains. Overall, these results support the model that bacteria maintain QS-responsive and non-responsive subpopulations at high cell densities in a bet-hedging strategy to simultaneously perform functions that are both positively and negatively regulated by QS to improve their fitness in fluctuating environments. © 2014 John Wiley & Sons Ltd.


Several protein tyrosine kinase (PTK) inhibitors predominantly isoflavones, such as genistein, erbstatin, quercetin, daidzein, present in red clover, cabbage and alfalfa, show apoptotic effect against cancer cells. In this study I found that biochanin, a methoxy form of genistein, inhibits IL-8-mediated activation of nuclear transcription factor kappaB (NF-κB) and activator protein 1 (AP-1) more potently than genistein as shown in Jurkat T-cell line. Both biochanin and genistein potently inhibited activity of Lck and Syk, but biochanin specifically inhibited activity of IKK. Biochanin inhibited completely NF-κB activation induced by PMA, LPS, pervanadate (PV), or H 2O 2, but only partially that induced by TNFα. Genistein was unable to inhibit IL-8-induced IKK activity, but it blocked PV-induced IKK activity. Biochanin inhibited activation of NF-κB by TRAF6 completely, but by TRAF2 partially. In silico data suggested that biochanin interacted strongly with serine/threonine kinase than genistein, though both equally interacted with PTK. The data show that both biochanin and genistein are potent inhibitors of PTK, but biochanin is a potent inhibitor of serine/threonine kinase too. Formononetin, having hydroxyl methoxy group is less potent to inhibit IKK than biochanin. Biochanin inhibits NF-κB activation not only by blocking the upstream IKK, but also PTK that phosphorylate tyrosine residues of IκBα. Thus, the double-edged sword effect of inhibition of NF-κB via inhibition of both serine/threonine kinase and PTK by biochanin might show useful therapeutic value against activities of cells that lead to tumorigenesis and inflammation. © 2012 Elsevier Inc. All rights reserved.


Acharya V.,DNA Diagnostics Center | Nagarajaram H.A.,DNA Diagnostics Center
Human Mutation | Year: 2012

Variations are mostly due to nonsynonymous single nucleotide polymorphisms (nsSNPs), some of which are associated with certain diseases. Phenotypic effects of a large number of nsSNPs have not been characterized. Although several methods have been developed to predict the effects of nsSNPs as "disease" or "neutral," there is still a need for development of methods with improved prediction accuracies. We, therefore, developed a support vector machine (SVM) based method named Hansa which uses a novel set of discriminatory features to classify nsSNPs into disease (pathogenic) and benign (neutral) types. Validation studies on a benchmark dataset and further on an independent dataset of wellcharacterized known disease and neutral mutations show that Hansa outperforms the other known methods. For example, fivefold cross-validation studies using the benchmark HumVar dataset reveal that at the false positive rate (FPR) of 20% Hansa yields a true positive rate (TPR) of 82% that is about 10% higher than the best-known method. © 2011 Wiley Periodicals, Inc.


Polyphosphate (polyP), a polymer of orthophosphate moieties released from the dense granules of activated platelets, is a procoagulant agent. Inositol pyrophosphates, another group of phosphate-rich molecules, consist of mono- and diphosphates substituted on an inositol ring. Diphosphoinositol pentakisphosphate (IP7), the most abundant inositol pyrophosphate, is synthesized on phosphorylation of inositol hexakisphosphate (IP6) by IP6 kinases, of which there are 3 mammalian isoforms (IP6K1/2/3) and a single yeast isoform. Yeast lacking IP6 kinase are devoid of polyP, suggesting a role for IP6 kinase in maintaining polyP levels. We theorized that the molecular link between IP6 kinase and polyP is conserved in mammals and investigated whether polyP-dependent platelet function is altered in IP6K1 knockout (Ip6k1(-/-)) mice. We observe a significant reduction in platelet polyP levels in Ip6k1(-/-) mice, along with slower platelet aggregation and lengthened plasma clotting time. Incorporation of polyP into fibrin clots was reduced in Ip6k1(-/-) mice, thereby altering clot ultrastructure, which was rescued on the addition of exogenous polyP. In vivo assays revealed longer tail bleeding time and resistance to thromboembolism in Ip6k1(-/-) mice. Taken together, our data suggest a novel role for IP6K1 in regulation of mammalian hemostasis via its control of platelet polyP levels.


The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties. The present invention also provides a kit for performing a multiplex assay for distinguishing basmati from non-basmati rice varieties. The kit may comprise a primer directed to an SSR loci, appropriate reagents for PCR, and optionally, a package insert for conducting the assay.


The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties. The present invention also provides a kit for performing a muliplex assay for distinguishing basmati from non-basmati rice varieties. The kit may comprise a primer directed to an SSR loci, appropriate reagents for PCR, and optionally, a package insert for conducting the assay.


The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties. The present invention also provides a kit for performing a multiplex assay for distinguishing basmati from non-basmati rice varieties. The kit may comprise a primer directed to an SSR loci, appropriate reagents for PCR, and optionally, a package insert for conducting the assay.


Patent
DNA Diagnostics Center | Date: 2015-04-22

A system and method for developing an avatar personalized from a users own DNA, where the avatar can borrow or include additional traits from other avatars. The avatar may be used in a variety of platforms, including games, profiles, etc. An avatar may be created from the DNA of others, such as a celebrity avatar. Examples of traits derived from a helix profile include, but are not limited to: Strength, Speed, Health, and Activity.

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