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Wayanad, India

Divya N.S.,DMWIMS | Srinivasamurthy V.,ESIC and PGIMSR
Journal of Clinical and Diagnostic Research | Year: 2014

Primary pure myxoid leiomyosarcoma of the ovary is extremely rare, comprising of only 1% of the ovarian tumours. Patient presented with a mass in the right iliac fossa since three months. Radiological diagnosis of broad ligament fibroid was given. Right salphingo-oophorectomy with enucleation of ischial fossa and wedge biopsy of left ovary was carried out. Based on gross, microscopy and immunohistochemistry a diagnosis of primary myxoid leiomyosarcoma of ovary was made. We report a rare case of primary pure myxoid leiomyosarcoma of the ovary with metastasis to ischial fossa emphasising on reliable prognostic markers. Ovarian leiomyosarcomas are highly aggressive tumours with poor prognosis.

Venkataiah V.,Vijayanagara Institute of Medical science | Vickram,DMWIMS | Thirumalarao K.R.,SSIMC and RC | Raiker V.G.,Basaveshwara Medical College and Hospital | Puttaswamy S.H.,VIMS
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Plasma sialic acid levels are elevated in Diabetes Mellitus (DM) patients with proteinuria. Renal damage is mainly caused by free radicals that are excessively generated in DM. Thiols play an important role in the cellular antioxidative defence mechanisms mainly through thiol-disulphide exchange reaction. Diallyl disulphide, a garlic oil principle component, is known for its anti-diabetic properties. Its structural analogue, Diaceto-Dipropyl Disulphide (DADPDS), is a less toxic and more palatable disulphide and possesses similar anti-diabetic actions. Aim: This study was undertaken to assess the usefulness of DADPDS in prevention of de-sialation of Glomerular Basement Membrane (GBM) in alloxan diabetic rats and to assess effect of DADPDS on renal tissue thiol levels. Materials and Methods: Rats were divided into Normal, Diabetic and DADPDS treated diabetic groups. Diabetes was induced by intraperitoneal injection (IP) of alloxan. DADPDS was fed by gastric intubation. Plasma Sialic acid was determined by Ehrlich’s method and renal tissue thiol levels by Nitroprusside reaction method. Results: This study showed a significant decrease (p<0.001) in plasma sialic acid, plasma glucose and renal tissue TBARS levels along with significant increase (p<0.001) in renal tissue thiol levels in DADPDS treated alloxan diabetic rats when compared to diabetic control rats. Conclusion: Hence it may be concluded that DADPDS helps in preventing de-sialation of GBM in alloxan diabetic rats and improves renal tissue antioxidant defence mechanisms, may be through thiol-disulphide exchange reaction and thereby exhibits a possible clinical use in prevention of renal complications like diabetic nephropathy. © 2016, Journal of Clinical and Diagnostic Research. All Rights Reserved.

Bhavuray T.,DMWIMS
Journal of Clinical and Diagnostic Research | Year: 2013

Adult intussusception is relatively rare in patients with bowel obstructions. Adult invagination is mostly caused by benign tumours. Intussusceptions caused by inflammatory fibroid polyps (IFPs) are uncommon. IFPs are rare, localized, non-neoplastic lesions originating in the submucosa of the gastrointestinal tract. We are reporting a rare case of intestinal obstruction caused by an ileo-ileal intussusception, caused by an IFP, a rare but peculiar and always benign tumour.

Nandeesh M.,DMWIMS | Sharathchandra B.J.,JSS University | Thrishuli P.B.,JSS University
Journal of Clinical and Diagnostic Research | Year: 2013

Background and Objectives: Empyema thoracis is a condition in which pus collects in the pleural cavity. The optimal treatment of Empyema thoracis especially in the fibrinopurulent phase (Stage II) remains controversial. While the Inter Costal Drainage (ICD) is less invasive and cheap, it is not clearly proved that it is better than the Video Assisted Thoracoscopic Surgery (VATS) in terms of conversion into thoracotomy, morbidity and duration of hospital stay. No large randomized trial is available for comparing the two treatment strategies in the condition. Methodology: This study was a prospective comparative study of ICD insertion versus VATS as primary intervention in the fibrinopurulent stage of Empyema thoracis, which was conducted over a period of 2 years (Dec 2008 to Nov 2010), in a tertiarry care Medical College Hospital. With an incidence of around 5-10% and a considerable burden in our hospital, the study was taken up to compare the efficacy of ICD versus VATS, in terms of morbidity and cost effectiveness and to identify the optimal way of managing the condition. The study included a total of 40 patients with each group consisting of 20 patients. Sampling: Purposive sampling technique. The Statistical Methods Used: Descriptive statistics, Frequencies, Crosstabs, Independent sample t-test. Results: It was found that VATS was better than the conventional ICD insertion in terms of the variables like mean duration of hospital stay (p<0.05), mean duration of the chest tube in situ (p<0.05), mean cost of the treatment (p<0.05), complications (p<0.05) and failure rate (p<0.05) which were statistically significant. Conclusion: Our study concluded that Video Assisted Thoracoscopic Surgery is better than conventional ICD tube insertion as a primary mode of treatment in the fibrinopurulent stage of Empyema thoracis.

Lakshman K.,DMWIMS | Laksman T.K.,DMWIMS
Journal of Clinical and Diagnostic Research | Year: 2015

Colonic lipomas are rare benign tumours that are usually asymptomatic. Large colonic lipomas can present with symptoms such as constipation, abdominal pain, bleeding per rectum, and intussusception. We report the case of an 82-year-old man presenting with sudden onset lower abdomen pain and features of peritonitis. An exploratory laparotomy revealed a perforation of sigmoid colon with a fleshy mass protruding through the perforation. No case of spontaneous perforated sigmoid colon by submucous giant lipoma is reported yet in the literature. We discuss the details of first such case, our management, the outcome and also briefly review the literature. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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