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Senthil R.A.,Thiruvalluvar University | Selvi A.,DKM college for Women Autonomous | Arunachalam P.,King Saud University | Amudha L.S.,Thiruvalluvar University | And 2 more authors.
Journal of Materials Science: Materials in Electronics | Year: 2017

This article presents the effect of hematite phase iron oxide (α-Fe2O3) on the electrocatalytic activity of graphene oxide (GO) for electrochemical detection of hydroquinone in aqueous solution. The different weight percentage (wt%) (1, 2 and 3%) of α-Fe2O3 added GO nanocomposites were synthesized by wet-impregnation method. The cyclic voltammetry studies using 2% α-Fe2O3-GO modified glassy carbon electrodes was found to exhibit an excellent electrocatalytic activity than α-Fe2O3 and GO electrodes that may be due to the synergistic effect of α-Fe2O3nanoparicles and GO sheet. In addition, the modified electrode exhibited a good reproducibility as well as long-term stability. Hence, the 2% α-Fe2O3-GO can be a promising catalytic material for electrochemical sensor applications. © 2017 Springer Science+Business Media New York

Asha S.,Dkm College For Women Autonomous | Asha A.,Dkm College For Women Autonomous | Rajeshkumar S.,Vellore Institute of Technology
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: The objective of this study is to investigate a simple and feasible approach for the production of silver nanoparticles (AgNPs) by using leaf extract of Ipmoea nil and to evaluate its antibacterial activity. Methods: The AgNPs synthesized was characterized by a change in color and the absorption peaks by ultraviolet-visible spectroscopy. The phyto compounds responsible for the reduction and capping of silver ions was known from Fourier transform infrared spectra and phytochemical analysis. The antibacterial effects of prepared aqueous AgNPs were detected against five types of pathogenic bacteria, including Gram-negative and Gram-positive bacteria (Escherichia coli, Salmonella, Bacillius, Proteus, and Klebsilla pneumonia) using agar well diffusion method. Results: A peak absorption value between 400 and 450 nm and the color change of the extract from yellowish to red wine were corresponds to the plasmon absorbance of AgNPs. On the other hand, aqueous extract of I. nil mediated AgNPs found to be effective against tested microorganisms (Salmonella, Bacillus, and Proteus) with inhibition zone in the range of 10-13 mm (20 µl and 10 µl) except E. coli and K. pneumonia. Furthermore, aqueous extract of I. nil leaves had no ability to suppress the growth of the tested microorganisms in the concentration of 10 µl. The control also produced similar inhibition zones like AgNPs. Conclusions: Our findings indicated that green synthesized AgNPs mediated by I. nil leaf extract had an efficient anti-bactericidal activity against the bacterial species tested. Hence, further studies are needed to highlight its mechanism and application as an antibacterial agent. © 2017 The Authors.

Sangeetha V.,Sathyabama University | Sudha P.N.,Dkm College For Women Autonomous | Gomathi T.,Dkm College For Women Autonomous
Materials Today: Proceedings | Year: 2016

Chitosan is a valuable component for many polymer blends and their composites. Chitosan has various functional properties. Hence it has been used for the improvement of properties of other polymeric materials through blending. The advantages of using nanoparticles are controlling the particle size and surface area related properties. Nanochitosan prepared from chitosan, possesses excellent physicochemical, environmentally benign properties and bioactivities. In this study binary and ternary polymer blends of Nanochitosan (NC), Polyvinylpyrollidone (PVP) and Silk Fibroin (SF) were prepared by solution casting method with glutaraldehyde as the cross linker. Glutaraldehyde was incorporated into polymer blends to improve the properties such as Mechanical strength, Tensile strength and Surface hardness. The prepared binary and ternary blends were subjected to various spectral studies and the results are discussed. © 2016 Elsevier Ltd.

Vinayagam A.,Sathyabama University | Sudha P.N.,DKM College for Women Autonomous
Asian Journal of Chemistry | Year: 2013

Present work was undertaken to study antioxidant free radical scavenging activity of leaves and flowers extracts of Leucas indica. Crude methanolic extracts was screened for in vitro antioxidant free radical scavenging activity by diphenyl picryl hydrazyl, nitric oxide radical scavenging and superoxide radical scavenging assay methods. Results showed that IC50 value of methanol extracts of leaves in diphenyl picryl hydrazyl, nitric oxide scavenging and superoxide radical scavenging assays are 241.11, 282.97 and 250.45 μg/mL. Similarly IC50 value of methanol extracts of flowers in diphenyl picryl hydrazyl, nitric oxide scavenging and superoxide radical scavenging assays are 0.19, 2.05 and 2.15 μg/mL, respectively. Phytochemical screening revealed that flavonoids, alkaloids and phenolic compound are present in methanol extracts of leaves and flowers and may be responsible for the antioxidant activity. The result showed that Leucas indica flowers are more potential free radical scavenging activity than leaves.

Dhanam N.,Dkm College For Women Autonomous | Thamaraichelvan A.,Thiagarajar College of Engineering
International Journal of ChemTech Research | Year: 2015

The synthesis and crystal structure of the title compound, [N-(4 chlorobenzyl) piperazineH2]CuCl4.Cl2 of molecular formula C22H34N4Cl2CuCl6 has been prepared and studied by X-ray diffraction method. The crystals are orthorhombic, Abm2, with a = 7.1344(2), b = 44.191(2), c = 9.1061(4), z = 4 and a final R value of 0.0289. Flattening of the tetrahedral CuCl42- anion occurs to such an extent that the structure is closer to the rarely encountered slightly distorted square with an average trans angle of 166.305°. The structure consists of a CuCl42- anion, two lattice Cl- ions and two (N-4-ClBzPipzH2)2+cation which are hydrogen bonded to anions through N-H…..Cl weak bonds thus stabilizing the planar like geometry of the anion. The electronic spectrum reveals the d-d and charge transfer bands at 450 nm and 320 nm respectively. The protonation of N-(4-chlorobenzyl)piperazine moiety and the occurrence of hydrogen bonding interactions are deduced from vibrational spectra. The thermal analysis is in accordance with the structural features. Computational studies established the presence of H-bonding and other interactions among the various moieties. Further, anti-microbial activities of the compound have also been established. © 2015, Sphinx Knowledge House. All rights reserved.

Dhanam N.,Dkm College For Women Autonomous | Thamaraichelvan A.,Thiagarajar College of Engineering
International Journal of ChemTech Research | Year: 2015

A new ionic salt of N-(2-pyridyl)piperazinium tetrachlorocuprate(II) (PPCC) has been synthesized and characterized by UV-Visible, FT-IR, TGA and NMR analyses. The structure was confirmed by single crystal XRD. It is monoclinic, with the space group of P21/c with the values of a = 9.194(5) Å; b = 16.152(5) Å; c = 9.471(5) Å and α = 90°, β =99.254(5) °, 90° = 90.000(5) ° and Z = 4. The anion shows a chloride-bridged binuclear structure with Cu….Cu distance of 3.935 Å; the two Cu(II) ions have distorted trigonal bipyramidal geometry. Extensive hydrogen bonding between the cation and the tetrachlorocuprate(II) unit found to stabilize the structure. DFT calculations and the anti microbial activities of the titled compound were also carried out. © 2015, Sphinx Knowledge House. All rights reserved.

Moorthy V.,DKM College for Women Autonomous | Ramalingam A.,DKM College for Women Autonomous | Sumantha A.,DKM College for Women Autonomous | Shankaranaya R.T.,Azyme Biosciences Private Ltd
African Journal of Microbiology Research | Year: 2010

L-asparaginase is an anti-neoplastic agent used in lymphoblastic leukaemia chemotherapy. Soil microbial isolates were screened for potential producers of L-asparaginase using a phenol red indicator growth medium and the microbe producing the largest hydrolysis zone was selected. The isolate was characterised by biochemical tests and was found to belong to Bacillus sp. The enzyme production was carried out by submerged fermentation. Two different carbon sources, glucose and maltose were used for the enzyme production and glucose was found to be the better carbon source. The enzyme was partially purified by ammonium sulphate precipitation. Dialysis was carried out to remove the excess salt and complete purification was achieved by ion-exchange chromatography. The characterised enzyme exhibited maximal enzyme activity at pH 7 and temperature 37°C. The enzyme was activated by MgCl 2 and inhibited by EDTA. Protein profiling by SDS-PAGE revealed the molecular weight of the protein to be 45 kDa.©2010 Academic Journals.

Ramya R.,Tamil University | Sudha P.N.,Dkm College For Women Autonomous
Polymer Composites | Year: 2013

The binary chitosan/silk fibroin composite synthesized by reinforcement of silk fibroin fiber into the homogenous solution of chitosan in formic acid was used to investigate the adsorption of two metals of Cu(II) and Cd(II) ions in an aqueous solution. The binary composite was characterized by Fourier transform infrared and scanning electron microscopy. The optimum conditions for adsorption by using a batch method were evaluated by changing various parameters such as contact time, adsorbent dose, and pH of the solution. The experimental isotherm data were analyzed using the Freundlich and Langmuir equations, indicated to be well fitted to the Langmuir isotherm equation under the concentration range studied, by comparing the correlation co-efficient. Adsorption kinetics data were tested using pseudo-first-order and pseudo-second-order models. Kinetics studies showed that the adsorption followed a pseudo-second-order reaction. Due to good performance and low cost, this binary chitosan/silk fibroin composite can be used as an adsorbent for removal of Cu(II) and Cd(II) from aqueous solutions. © 2013 Society of Plastics Engineers.

Deevika B.,Dkm College For Women Autonomous | Asha S.,Dkm College For Women Autonomous | Taju G.,Cabdul Hakeem College | Nalini T.,Dkm College For Women Autonomous
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Cadmium, found to be a toxic metal causes damage to organs such as kidney, lungs, bones, liver, brain and reproductive organ testes. But the most affected organ is kidney on cadmium exposure. In this study, cadmium toxicity and curcumin antioxidant activity against nephrotoxicity were analysed. Here twenty four rats were taken and divided into four groups,each group comprised of six animals each. The first group served as control group with a normal feed and water. The second group received cadmium acetate in distilled water(200 mg/kg of body weight) for 7 days. The third group received only curcumin, dissolved in glycerol (250 mg/kg of body weight) for the same experimental days. Finally, the fourth group is the pretreated group. Rats were treated with curcumin and cadmium acetate continuously for 7 days. At the end of experiment, animals were sacrificied and the blood sample, tissue samples analysed. The level of urea and creatinine in serum were found to be increased, the antioxidant enzymes like superoxide dismutase, catalase were decreased in tissue sample. All these, confirmed the protective activity of curcumin on induced nephrotoxicity.

Deevika B.,Dkm College For Women Autonomous | Asha S.,Dkm College For Women Autonomous | Taju G.,Cabdul Hakeem College | Nalini T.,Dkm College For Women Autonomous
International Journal of Research in Pharmaceutical Sciences | Year: 2012

Pollution is a worldwide environmental problem that affects our environment in a wide range. These pollutants causes a great variety of health problems. Among them, toxic metals play an important role. The one comnmon toxic metal is cadmium. Curcumin (diferuoyl methane) is a well-knowm biologically active compound in tumeric derived from the rhizome of plant curcuma longa. curcuma longa is a gold coloured spice most commonly used in food as colouring agent and also for preservation of food. The aim of our present study was to evaluate the toxici-ty nature of cadmium acetate and antioxidant capacity of curcumin on liver injury in albino mice. The animals were randomly divided into four groups, each with six animals. Group I (control group) received normal feed, Group II was administered with cadmium acetate (200 mg/kg) dissolved in water, Group III was administered only with curcumin and Group IV received a dose of 250 mg/kg of curcumin and 200 mg/kg of cadmium acetate. The experiment was conducted for the period of 7 days. Rats treated with cadmium acetate alone showed a increased activity of ALT, AST and a decreased activity of ALP, Protein concentrartion in serum. And also a marked decline in antioxidant enzymes like Superoxide dismutase and Catalase in cadmium acetate induced rats. However, on com-bined treatment of rats with curcumin and cadmium acetate provoked the above changes more significantly, when compared to each of them as alone. Hence it is suggested that curcumin has a protective effect against a cadmium acetate induced hepatic injury. © JK Welfare & Pharmascope Foundation.

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