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Cihan S.,Okmeydani Research and Training Hospital | Atasoy A.,Diyarbakir Research and Training Hospital | Yildirim Y.,Dicle University | Babacan N.A.,Cumhuriyet University | Kos T.F.,Kahramanmaras Sutcu Imam University
Tumori | Year: 2015

The majority of the chemotherapy agents in use today cause various infusion reactions, from mild flushing to life-threatening events. The frequency of the reported hypersensitivity reactions induced by cetuximab varies between 3% and 22%. It is recommended in the literature to stop the infusion and replace cetuximab with panitumumab in case of hypersensitivity reactions observed during the treatment of colon cancer. Tumor lysis syndrome (TLS) may occur in colorectal cancers with heavy tumor load. Tumor lysis syndrome may be life-threatening. In our patient with widespread bone and liver metastases, treatment continued with cetuximab as a combination therapy with irinotecan in spite of the hypersensitivity and TLS led to a complete treatment response. The complete response observed after 3 months through continued therapy in our patient may present an example supporting treatment with cetuximab in spite of severe reactions. © 2015 INTM, Italy.

Sogut O.,Bezmialem Foundation University | Solduk L.,Diyarbakir Research and Training Hospital | Gokdemir M.T.,Harran University | Kaya H.,Harran University
Biomedical Research (India) | Year: 2015

We investigated the impact of paracetamol administration on lymphocyte DNA damage and oxidative stress parameters for acute pain management in patients with acute trauma-related pain. Thirty-five adult patients with mild or moderate trauma and 33 eligible healthy volunteers as control subjects were enrolled. Blood samples were obtained from the patients before and at 2 and 12 h after IV administration of paracetamol. Serum lymphocyte DNA damage and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were studied as oxidative stress parameters. Serum lymphocyte DNA damage levels were 14.97 ± 12.38 AU (arbitrary units) in Group 1 (before analgesia), 13.94 ± 9.28 AU in Group 2 (2 h after analgesia), and 10.57 ± 8.73 AU in Group 3 (12 h after analgesia). A significant difference was observed among the groups with respect to serum lymphocyte DNA damage (p < 0.01). Mean serum TOS and OSI values were lower in Groups 2 and 3 compared to that in Group 1. Furthermore, mean serum TAS values were higher in Group 3 compared to that in Goup 1. Our data suggest that the treatment of trauma-related acute pain with intravenous paracetamol resulted in decreased DNA damage in human T lymphocytes. © 2015, Scientific Publishers of India. All right reserved.

Soyer V.,Inonu University | Ara C.,Inonu University | Yaylak F.,Dumlupinar University | Sarici B.,Inonu University | And 3 more authors.
International Journal of Surgery Case Reports | Year: 2015

Introduction Alveolar echinococceal disease of the liver is rare. Echinococcus multilocularis is responsible for the development of the related clinical conditions. Advanced disease may result with serious complications such as end stage liver disease and Budd-Chiari syndrome. Presentation of case In this presentation, a 28 years-old woman who was a case with advanced alveolar echinococcosis complicated with a Budd-Chiari syndrome and was performed successful living donor liver transplantation, has been demonstrated with clinical and radiological images. Discussion Initially there may be no clinical evidence of the disease in humans for years. Severity and fatality are the significant characteristics of the natural history. Extension to the surrounding tissues and metastasis of the parasitic mass may be observed. Prevention is essential in disease control. Serologic assay may identify the parasite. However, early diagnosis is rare. Staging is based on radiologic imaging. Some patients with advanced disease may require surgery. Hepatic resection and liver transplantation are accepted procedures in selected patients. Conclusion The importance of early diagnosis to prevent advanced complications such as development of Budd-Chiari syndrome and metastasis has been underlined. © 2015 The Authors.

Balikci H.H.,Susehri Government Hospital | Gurdal M.M.,Uskudar Government Hospital | Ozkul M.H.,Haseki Research and Training Hospital | Karakas M.,Haseki Research and Training Hospital | And 4 more authors.
European Archives of Oto-Rhino-Laryngology | Year: 2013

Neck masses can be classified into three main categories: congenital, inflammatory and neoplastic. Our aim was to determine the distribution of diagnosis in patients who were followed-up for a neck mass and had undergone surgery for diagnostic indications. Six hundred and thirty cases referred to the Otorhinolaryngology and Head Neck Surgery Department of Haseki Research and Training Hospital between January 2005 and February 2012 with a neck mass who underwent excisional or incisional biopsy to establish a histopathologic diagnosis were retrospectively evaluated. Patients with a diagnosis of upper aerodigestive tract malignancy were excluded from the study. As well as the patients with thyroid masses were excluded. Only unknown primary neck masses were included in the study. The neck masses were categorized as inflammatory (33.49 %), congenital (18.9 %) or neoplastic (47.6 %). Neoplastic masses were either benign (51 %) or malignant (49 %) tumors. The most common causes were tuberculous lymphadenitis (40.28 %) among inflammatory masses, thyroglossal duct cysts (32.77 %) among congenital masses, pleomorphic adenoma (22.33 %) among benign neoplastic masses, and lymphoma (20 %) among malignant neoplastic masses. The most common types of mass were congenital in the 0-20 year age group, benign neoplastic in 21-40-year-old and malignant neoplastic in the >40-year group. Any neck mass, especially in an elderly patient, should be managed with caution as a considerable proportion may be malignant. In children and adolescents, a neck mass requiring surgery is most likely to be congenital. Tuberculosis should be considered as a cause of a neck mass due to a long-term inflammatory process in a developing country. © 2013 Springer-Verlag Berlin Heidelberg.

Ozbay I.,Diyarbakir Egitim Arastirma Hastanesi | Balikci H.H.,Susehri Government Hospital | Alp A.,Eyup Government Hospital | Bilman F.B.,Diyarbakir Research and Training Hospital
International Journal of Pediatric Otorhinolaryngology Extra | Year: 2013

Tonsillectomy has been associated with complications such as bleeding, pain, dehydration, edema, airway obstruction, atlantoaxial subluxation and infection. However, fungal infection is a very rare complication of tonsillectomy. We describe the case of a 12-year-old girl who developed oral Candida infection as a complication of tonsillectomy. She had pain and difficulty in swallowing on the third postoperative day, and a local examination revealed an easily grazing, white plate on the tonsillar fossa. A culture of the lesion tissue identified Candida albicans. Local nystatin therapy was administered, and the lesion healed completely by postoperative day 12. We conclude that fungal infection, though rare, can occur as a complication of tonsillectomy. © 2013 Elsevier Ireland Ltd.

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