Cape Saint Claire, MD, United States
Cape Saint Claire, MD, United States

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Meng S.,Divisions of Metabolism and Endocrinology | Cao J.,Divisions of Metabolism and Endocrinology | He Q.,Divisions of Metabolism and Endocrinology | Xiong L.,Divisions of Metabolism and Endocrinology | And 4 more authors.
Journal of Biological Chemistry | Year: 2015

Background: The mechanism underlying the activation of AMPK by metformin remains unclear. Results: Metformin promotes the formation of AMPK αβγ heterotrimeric complex. Conclusion: The formation of the AMPK αβγ heterotrimeric complex augments AMPK αβγ phosphorylation by LKB1 and prevents dephosphorylation by protein phosphatase. Significance: Metformin-mediated formation of the AMPK αβγ heterotrimeric complex results in AMPK activation by elevating AMPK phosphorylation at Thr-172. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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