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Lungu A.,Polytechnic University of Bucharest | Albu M.G.,Leather and Footwear Research Institute Division | Florea N.M.,Polytechnic University of Bucharest | Stancu I.C.,Polytechnic University of Bucharest | And 2 more authors.
Digest Journal of Nanomaterials and Biostructures | Year: 2011

This report describes the preparation and characterization of collagen-glycosaminoglycan (Coll-GAG) porous scaffolds with potential uses in tissue engineering. The combination of collagen and GAG has shown advantages over the use of either the material alone. Specific interactions in these scaffolds could exist due to the hydrogen bonding between O-H of GAG and C=O of collagen or between C=O of GAG and N-H of collagen. Scaffolds microstructure (porosity, mean pore size, interconnectivity) was evaluated using SEM. Also the addition of GAGs not only improved the water uptake significantly but also extended the degradation time of Coll-GAG scaffolds in comparison with Coll. The results suggest that the obtained Coll-GAG matrices as an analog of the natural threedimensional extracellular matrix may be useful for in vitro investigation to support the attachment, proliferation and migration of a variety of cells. Source

Lungu A.,University of Bucharest | Titorencu I.,Institute of Cellular Biology and Pathology Nicolae Simionescu | Albu M.G.,Leather and Footwear Research Institute Division | Florea N.M.,University of Bucharest | And 4 more authors.
Digest Journal of Nanomaterials and Biostructures | Year: 2011

Numerous studies recommend collagen to be employed in constructing scaffolds for bone tissue engineering. The aim of this study was to test whether addition of hyaluronic acid (HA) and of human bone morphogenetic protein 4 (BMP-4) to collagen scaffolds improves its physical-chemical and morphological properties and biocompatibility with human MG 63 osteoblast-like cells. Type I fibrillar collagen, HA and BMP-4 were used to prepare 3D porous scaffolds by freeze-drying method. The structure of these natural polymers was stabilized employing 0.25% glutaraldehyde, a method that warrants that all the scaffolds components keep their structural integrity and biological properties. The physical-chemical properties were assessed using infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetry (TG/DTG); the morphological properties were evaluated by scanning electron microscopy (SEM) and water uptake. The biological properties were determined (in vitro) by collagenase degradation and by assessment of the biocompatibility with MG 63 osteoblast-like cells. The results demonstrated that the collagen scaffolds with HA and BMP-4 had good physical-chemical and morphological properties, promoted adhesion, maintained viability and sustained the migration of osteoblast-like cells into scaffolds. Source

Chelaru C.,Polytechnic University of Bucharest | Ignat M.,Leather and Footwear Research Institute Division | Albu M.,Leather and Footwear Research Institute Division | Meghea A.,Polytechnic University of Bucharest
UPB Scientific Bulletin, Series B: Chemistry and Materials Science | Year: 2015

Microencapsulation is one of the latest technologies used for imparting an array of unique characteristics to a textile. The paper presents a new method for the synthesis of microcapsules based on natural polymers and lemon essential oil (μcLO). The new synthesized microcapsules were characterized by optical microscopy, gas chromatography, FT-IR (ATR) spectroscopy, DLS, SEM and their antimicrobial activity was tested against E. coli, after dispersing it on textile samples. They proved significant bactericidal effects against microorganisms such as E. coli. Source

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