Division for Chemical Research

Budapest, Hungary

Division for Chemical Research

Budapest, Hungary
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Jablonkai E.,Budapest University of Technology and Economics | Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Drahos L.,Hungarian Academy of Sciences | Keglevich G.,Budapest University of Technology and Economics
Tetrahedron Letters | Year: 2013

1-Hydroxy-phospholene 1-oxides (1 and 3) and 1-hydroxy-phospholane oxides (5 and 7) undergo fast and efficient esterification with a series of alcohols, at room temperature, in the presence of 1.1 equiv of propylphosphonic anhydride (T3P®). © 2013 Elsevier Ltd. All rights reserved.


Grun A.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Foldesi T.,Budapest University of Technology and Economics | Abranyi-Balogh P.,Budapest University of Technology and Economics | And 2 more authors.
Synthetic Communications | Year: 2013

Twenty-five amides were synthesized in almost quantitative yields by microwaveassisted condensation of arylacetic acids and 2-aryl-ethylamines under solventless conditions. The N-arylethyl-arylacetylamides are intermediates of the corresponding isoquinoline derivates. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright © Taylor & Francis Group, LLC.


Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Abranyi-Balogh P.,Budapest University of Technology and Economics | Dancso A.,Division for Chemical Research | Keglevich G.,Budapest University of Technology and Economics
Journal of Sulfur Chemistry | Year: 2012

Thioamides are prepared in moderate-to-good yields from the benzylamines or benzylamine derivatives by treatment with elemental sulfur under microwave and solvent-free conditions at 170.C in 15 min. © 2012 Taylor & Francis.


Milen M.,Division for Chemical Research | Milen M.,Budapest University of Technology and Economics | Grun A.,Budapest University of Technology and Economics | Balint E.,Budapest University of Technology and Economics | And 2 more authors.
Synthetic Communications | Year: 2010

The solid-liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods. Copyrigh © 2010 Taylor and Francis Group, LLC.


Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Abranyi-Balogh P.,Budapest University of Technology and Economics | Dancso A.,Division for Chemical Research | Keglevich G.,Budapest University of Technology and Economics
Synthesis (Germany) | Year: 2012

The reaction of 6,7-dihydrothieno[3,2-c]pyridine derivatives with 1,3-dipoles, such as a nitrile oxides or nitrile imines, gave novel fused heterocycles. The Staudinger reaction of the starting material was also studied. This reaction was stereoselective and exclusively gave racemic cis-cycloadducts in which the thienopyridine core was fused with a β-lactam ring. © Georg Thieme Verlag KG · Stuttgart · New York.


Abranyi-Balogh P.,Budapest University of Technology and Economics | Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Dancso A.,Division for Chemical Research | And 3 more authors.
Heteroatom Chemistry | Year: 2013

New dihydro[3,2-c][1,2,4]triazolo[4,3-a]pyridines were synthesized by the reaction of 4-(methylsulfanyl)-6,7-dihydrothieno[3,2-c]pyridine with acid hydrazides. One bis(dihydrothienotriazolo-pyridine) was also prepared. In a few cases, the corresponding intermediate could be detected by LC-MS. The bromophenyl derivative was involved in Suzuki and Sonogashira cross-coupling reactions. © 2013 Wiley Periodicals, Inc.


Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Abranyi-Balogh P.,Budapest University of Technology and Economics | Dancso A.,Division for Chemical Research | And 2 more authors.
Heteroatom Chemistry | Year: 2013

New thienopyridine derivatives were synthesized by the reaction of 4-(methylsulfanyl)-6,7-dihydrothieno[3,2-c]pyridine (5) with amino acids. The use of β-amino acids led to thienopyridopyrimidone derivatives (9a-g). Using α-amino acids, such as glycine and racemic alanine under the same reaction conditions, compounds with two thienopyridine units were obtained. The structure of the novel compounds was confirmed by IR, 13C, and 1H NMR spectroscopy, as well as mass spectrometry, along with single crystal X-ray analysis. © 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:124-130, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21073 © 2013 Wiley Periodicals, Inc.


Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Abranyi-Balogh P.,Budapest University of Technology and Economics | Balogh G.,Budapest University of Technology and Economics | And 2 more authors.
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2012

N-Heterocycles including indolecarbaldehyde, substituted benzimidazoles, and methylimidazole could be efficiently phosphorylated by diethyl chlorophosphate at room temperature in different solvents using alkali carbonate or triethylamine as the base. However, the phosphorylation of N-heterocycles with a lower reactivity at the NH function, such as carbazole and phenothiazine, could not be conducted to complete conversion under the conditions applied. Copyright © 2012 Taylor and Francis Group, LLC.


Milen M.,Budapest University of Technology and Economics | Milen M.,Division for Chemical Research | Abranyi-Balogh P.,Budapest University of Technology and Economics | Mucsi Z.,Budapest University of Technology and Economics | And 3 more authors.
Current Organic Chemistry | Year: 2011

The reaction of 3,4-dihydro-β-carboline derivatives with 1,3-dipoles, such as a nitrile imine and a nitrile oxide led to triazolopyridoindole and oxadiazolo-pyridoindole derivatives, respectively, that are novel synthetic alkaloids. Stereostructure, stability and further reactions of the pyridoindoles were also investigated. The oxadiazolo-pyridoindoles underwent reaction with a second unit of nitrile oxide to afford the corresponding trisubstituted 1,2,4-triazole 2-oxides. The mechanisms of the above reactions were studied in detail by high level quantum chemical calculations. It was found that the reaction of the 1,3-dipoles is not an expected 1,3-cycloaddition, but rather a stepwise addition reaction. The exact mechanism was found to be dependent on the substitution pattern. © 2011 Bentham Science Publishers Ltd.


Milena M.,Budapest University of Technology and Economics | Milena M.,Division for Chemical Research | Abranyi-Balogha P.,Budapest University of Technology and Economics | Dancso A.,Division for Chemical Research | And 2 more authors.
Letters in Organic Chemistry | Year: 2010

The reaction of 3,4-dihydro-β-carboline 5a with the nitrile oxide generated from 4-fluoro-Nhydroxybenzenecarboximidoyl chloride (6) gave novel adduct 7a that on standing at 26 °C in CDCl3 was isomerized to species 8. As an extension, the reaction of the dihydro-β-carbolines substituted on C(1) (5b-e) afforded the analogous adducts (7b-e). In case of using two equivalents of reagent 6, the corresponding 1,2,4-triazole-2-oxide (10b-e) was also formed beside the adduct (7b-e). © 2010 Bentham Science Publishers Ltd.

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