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Uppal Kalan, India

Rao B.V.,Dissymmetrix Pvt. Ltd | Hariharakrishnan V.S.,Dissymmetrix Pvt. Ltd | Dubey P.K.,Jawaharlal Nehru Technological University
Asian Journal of Chemistry | Year: 2012

Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data. Source


Venugopala Rao B.,Dissymmetrix Pvt. Ltd | Hariharakrishnana V.S.,Dissymmetrix Pvt. Ltd | Dubey P.K.,University of Hyderabad
Der Pharma Chemica | Year: 2011

Reaction of 2-(4-Aminophenyl)-N-methylethanesulfonamide (1) with thiophosgene in chloroform gives 2-(4-Isothiocyanatophenyl)-N-methylethanesulfonamide (2), which on reaction with 4-pyridine carboxylic acid hydrazide gives 2-Isonicotinoyl-N-(4-(2-(N-methylsulfamoyl) ethyl) phenyl) hydrazine carbothio amide (3). Treatment of 3 in alkaline and acidic media, gives the corresponding 1,2,4-triazole-5-thiols (4) and 1,3,4-thiadiazoles (5) respectively. Condensation of 2 with 3-aminopropan-1-ol in THF and followed by cyclisation in presence of conc. hydrochloric acid gives 1,3-thiazine (6). All the synthesized compounds were characterized by their FT-IR, 1H-NMR and mass spectral data. Source


Venugopala Rao B.,Dissymmetrix Pvt. Ltd | Krishnana V.S.H.,Dissymmetrix Pvt. Ltd | Venkateswara Rao K.,Dissymmetrix Pvt. Ltd | Ravi Sankar V.,Dissymmetrix Pvt. Ltd | Dubey P.K.,University of Hyderabad
Der Pharma Chemica | Year: 2011

A novel intermediate N-benzyl-N-methylethenesulfonamide (3) synthesis has been reported. This on reaction with 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole (4) under heack condition gave N-benzyl-N-methyl-2-[3-(1-methyl-1, 2, 3, 6,-tetrahydro pyridine -4-yl)-1H-indol-5-yl] ethene sulfonamide (5). Later on 5 was subjected to the hydrogenation, followed by debenzylation to afford naratriptan (1) with high purity. Source

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