Diskapi YIldirim Beyazit Research and Education Hospital

Ankara, Turkey

Diskapi YIldirim Beyazit Research and Education Hospital

Ankara, Turkey

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Acar U.,Hacettepe University | Pinarli F.A.,Diskapi Yildirim Beyazit Research and Education Hospital | Acar D.E.,Zekai Tahir Burak Womens Health Research and Education Hospital | Beyazyildiz E.,Samsun Research and Education Hospital | And 4 more authors.
Ophthalmic Research | Year: 2015

Aims: To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. Methods: A total of 60 Sprague-Dawley rats with clinically proven alkali injury were divided into four equal groups (n = 15) as follows: group 1: 2 × 105 cells/drop LMSCs, topically applied 6 times a day for 2 days; group 2: 2.4 × 106 cells in 0.5 ml LMSCs, subconjunctivally applied; group 3: 2.4 × 106 cells in 1 ml LMSCs, intraperitoneally applied, and group 4: no LMSC treatment. The groups were compared according to grades of corneal opacity (CO), corneal neovascularization (CNV) and corneal fluorescein staining (CFS). The migration of LMSCs into the cornea and the inflammatory characteristics of the groups were evaluated with BrdU (5-bromo-2′-deoxyuridine bromodeoxyuridine) immunostaining and histopathologically in a 4-week follow-up. Results: There were statistically significant differences between the LMSC-treated and control groups in each week regarding mean CO scores and in the 3rd week regarding the mean CNV and CFS scores (p < 0.05). The statistical significance was due to the differences between the topical and the control group and between the subconjunctival and the control group. BrdU+ LMSCs were seen in the corneal epithelium of the all LMSC-administered rats, and fewer inflammatory changes were observed in these rats. Conclusion: Allogeneic LMSC treatment, especially topical and subconjunctival administration, seems to be helpful in affecting corneal healing after a severe corneal burn. © 2015 S. Karger AG, Basel.


Akdemir R.,Diskapi YIldirim Beyazit Research and Education Hospital | Karakurt O.,Diskapi YIldirim Beyazit Research and Education Hospital | Kilic H.,Diskapi YIldirim Beyazit Research and Education Hospital | Yesilay A.B.,Diskapi YIldirim Beyazit Research and Education Hospital | And 4 more authors.
Heart and Vessels | Year: 2010

It is known that primary angioplasty is more effective than thrombolytic therapy for the treatment of ST-segment elevation acute myocardial infarction. The aim of the present study is to compare the effects of the two strategies on the left ventricular functions using the Tei index (a combined myocardial performance index). Of 81 patients (11 female, mean age 52.7 ± 11.9 years, and 70 male, mean age 54.8 ± 11.5 years) matching the selection criteria, 41 patients were treated by primary percutaneous transluminal coronary angioplasty and stenting (group A, 41 patients) and 40 patients were treated by thrombolytic agents (streptokinase) (group B, 40 patients). All patients underwent a complete two-dimensional transthoracic echocardiographic and Doppler study in the left lateral decubitus position from multiple windows. There was no significant difference between the two groups in isovolumetric contraction time and ejection time. Isovolumetric relaxation time was 95.2 ± 18.4 in group A and 116.2 ± 28.1 in group B (P = 0.001) and the Tei index was 0.51 ± 0.12 in group A and 0.59 ± 0.16 in group B (P = 0.019). Isovolumetric relaxation time and Tei index were significantly higher in group B. Primary angioplasty is superior to thrombolytic therapy as assessed by the Tei index even in the first 3 h, with no apparent change in systolic function. © 2010 Springer Japan.


KahvecI R.,Krkkale Yuksek Ihtisas Hospital | Gunaydin A.,Diskapi Yildirim Beyazit Research and Education Hospital | Kalan M.,Diskapi Yildirim Beyazit Research and Education Hospital | Sanli M.,Diskapi Yildirim Beyazit Research and Education Hospital
Journal of Neurological Sciences | Year: 2015

Isolated sensorineural hearing loss due to posterior fossa benign cystic lesions is extremely rare. Although they are benign in the natural course, rarely they may cause progressive neurological symptoms. Radiologic and audiometric examinations are useful methods for initial diagnosis and follow-up evaluations. A 48 year old man suffered from left-sided progressive hearing loss for six months. Cranial magnetic resonance imaging showed that intrapontine cystic mass measuring 9 mm, enlarged 3 mm during the seven years period. In addition, auditory brainstem response revealed that prolonged 1-5 interpeak latency on the right side and wave 5th was absent on the left. In this report, we described a patient, who has progressive unilateral neural sensorineural hearing loss without any neurological symptoms, because of the enlarging intrapontine cystic mass, which compress to the lower auditory pathways. Although, isolated sensorineural hearing loss has been reported in intraaxial cystic lesions in consequence of cerebellopontine angle compression, but we do not encountered in the English literature that isolated sensorineural hearing loss due to compression of lower auditory pathways by intrapontine cystic mass. © 2015, Ege University Press. All rights reserved.


Akdemir R.,Sakarya University | Yeter E.,Diskapi Yildirim Beyazit Research and Education Hospital | Kilic H.,Diskapi Yildirim Beyazit Research and Education Hospital | Yucel M.,Sakarya University
Cardiology in the Young | Year: 2013

A 38-year-old man who had a history of percutaneous coronary artery coil occlusion was admitted to our hospital with chest pain and shortness of breath. His complaint was chest pain, which is typical. ST depressions were observed during the treadmill exercise stress test. Coronary angiography demonstrated the persistence of a coronary arteriovenous fistula and coils in the fistula. Primarily, additional coil placement inside the arteriovenous fistula was decided as the mode of treatment. The coil was first placed inside the arteriovenous fistula and then an attempt was made to detach it. However, it was unsuccessful after four trials and electrical detachment of more than 3 minutes. Finally, a 2.5 × 18-millimetre graft stent was deployed at 20 atmospheric pressure. Electrocardiographic recordings showed bizarre ST segment changes during the electrical detachment of the coil. In this report, we discuss the concealed bizarre electrocardiographic changes that were seen during coronary arteriovenous fistula occlusion. © 2012 Cambridge University Press.


Ariturk O.K.,Balikesir State Hospital | Ureten K.,Diskapi Yildirim Beyazit Research and Education Hospital | Sari M.,Diskapi Yildirim Beyazit Research and Education Hospital | Yazihan N.,Ankara University | And 2 more authors.
Turk Kardiyoloji Dernegi Arsivi | Year: 2013

Objectives: Familial Mediterranean fever (FMF) is an autosomal recessive disorder and the most frequent periodic syndrome characterized by recurrent attacks of polyserositis. Heart-type fatty acid-binding protein (h-FABP) is an intracellular molecule engaged in the transport of fatty acids through the myocardial cytoplasm and a rapid marker of myocardial injury. FMF is an autoinflammatory disease characterized by ongoing inflammatory activity. Inflammation also plays an important role in the development and progression of atherosclerosis in some rheumatic diseases. We aimed to investigate markers of atherosclerosis in patients with FMF by the measurement of serum h-FABP and malondialdehyde levels (MDA). Study design: Forty consecutive patients with FMF and twenty healthy volunteers were selected to participate in the study. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum h-FABP and MDA levels were determined to examine the association. Results: The mean h-FABP level in FMF patients was significantly higher than the normal population (4.89±0.83 vs. 3.06±2.13 ng/ml, p<0.01). The mean platelet volume was significantly higher in FMF patients than in the normal group (8.87±0.99 vs. 8.22±0.45 fl, p=0.04). Serum MDA levels were the same between the groups (1.08±0.66 vs. 1.08 ± 0.33 nmol/ml, p=0.99). h-FABP and MDA levels were the same in FMF patients with an acute attack and during an attack free period. Conclusion: Our results show that h-FABP increases in patients with FMF. Higher h-FABP levels may lead to increased atherosclerotic propensity in FMF, independent of the oxidative stress status of these patients. © 2013 Turkish Society of Cardiology.


Akdemir R.,Diskapi Yildirim Beyazit Research and Education Hospital | Agac M.T.,Ahi Evren Thoracic and Cardiovascular Surgery Research and Education Hospital | Acar Z.,Ahi Evren Thoracic and Cardiovascular Surgery Research and Education Hospital
Acta Cardiologica | Year: 2010

A 23-year-old man presented with dyspnoea and a blood pressure of 180/120 mmHg in both arms. Femoral and popliteal pulses were absent and there was a systolic ejection murmur along the left intercostal area.The chest X-ray showed rib notching and a normal cardiac silhouette. Transthoracic echocardiography showed a bicuspid aortic valve with a mild degree of left ventricular dysfunction and an interruption of the aorta 3 cm distally of the left subclavian artery. A 64-slice CT angiography confirmed an interruption with extensive collateral circulation. Angioplasty and implantation of a covered stent were successful. Six months after the procedure, the patient is asymptomatic and without any complication.


Karakurt O.,DIskapI YIldIrIm BeyazIt Research and Education Hospital | Akdemir R.,DIskapI YIldIrIm BeyazIt Research and Education Hospital
International Journal of Cardiology | Year: 2011

Coronary stents have marked an era in the interventional cardiology and have significantly decreased the rates of acute restenosis. Although diminished rates of restenosis have been observed with stents with respect to balloon angioplasty, restenosis is still a major problem of the interventional procedures. Stent thrombosis (ST) after percutaneous coronary intervention (PCI) is a rare and usually poor prognostic event that might result in myocardial infarction (MI) and sudden death .We wanted to summarize the main features of the issue. © 2009 Elsevier Ireland Ltd.


PubMed | Diskapi Yildirim Beyazit Research and Education Hospital
Type: Case Reports | Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | Year: 2010

Intradural spinal lipoma is rare and seen about 1% of all tumors of the spinal cord. Lipomas of the cervical location with intracranial extension are extremely rare and are described as intramedullary or subpial location.A 12-year-old female with lipoma of the cervicothoracic spinal cord demonstrated progressive quadriparesis. The patient underwent surgery with decompression of the affected craniocervical location.In the reported case, we describe a rare intradural lipoma of the cervicothoracic spinal cord with posterior fossa extension in the child, and the relevant English medical literature is reviewed.


PubMed | Diskapi Yildirim Beyazit Research and Education Hospital
Type: Case Reports | Journal: Acta cardiologica | Year: 2010

A 23-year-old man presented with dyspnoea and a blood pressure of 180/120 mmHg in both arms. Femoral and popliteal pulses were absent and there was a systolic ejection murmur along the left intercostal area.The chest X-ray showed rib notching and a normal cardiac silhouette.Transthoracic echocardiography showed a bicuspid aortic valve with a mild degree of left ventricular dysfunction and an interruption of the aorta 3 cm distally of the left subclavian artery. A 64-slice CT angiography confirmed an interruption with extensive collateral circulation. Angioplasty and implantation of a covered stent were successful. Six months after the procedure, the patient is asymptomatic and without any complication.


PubMed | Diskapi Yildirim Beyazit Research and Education Hospital
Type: Journal Article | Journal: Heart and vessels | Year: 2010

It is known that primary angioplasty is more effective than thrombolytic therapy for the treatment of ST-segment elevation acute myocardial infarction. The aim of the present study is to compare the effects of the two strategies on the left ventricular functions using the Tei index (a combined myocardial performance index). Of 81 patients (11 female, mean age 52.7 +/- 11.9 years, and 70 male, mean age 54.8 +/- 11.5 years) matching the selection criteria, 41 patients were treated by primary percutaneous transluminal coronary angioplasty and stenting (group A, 41 patients) and 40 patients were treated by thrombolytic agents (streptokinase) (group B, 40 patients). All patients underwent a complete two-dimensional transthoracic echocardiographic and Doppler study in the left lateral decubitus position from multiple windows. There was no significant difference between the two groups in isovolumetric contraction time and ejection time. Isovolumetric relaxation time was 95.2 +/- 18.4 in group A and 116.2 +/- 28.1 in group B (P = 0.001) and the Tei index was 0.51 +/- 0.12 in group A and 0.59 +/- 0.16 in group B (P = 0.019). Isovolumetric relaxation time and Tei index were significantly higher in group B. Primary angioplasty is superior to thrombolytic therapy as assessed by the Tei index even in the first 3 h, with no apparent change in systolic function.

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