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Yogyakarta, Indonesia

Wibawa H.,CSIRO | Wibawa H.,University of Queensland | Wibawa H.,Disease Investigation Center Wates | Bingham J.,CSIRO | And 11 more authors.
Comparative Immunology, Microbiology and Infectious Diseases | Year: 2013

To determine the pathobiology of Indonesian H5N1 highly pathogenic avian influenza, two viruses representing clades 2.1.1 and 2.1.3 were inoculated into broiler chickens and Pekin ducks via the eyes, nostrils and oropharynx. In chickens, both viruses produced fulminant disease; tissue tropism was broad but predominantly endothelial and viral loads in tissues were high. Except for one case of meningoencephalitis, the infection in ducks was sub-clinical, leading only to seroconversion. In these ducks, virus and viral antigen occurred in lower amounts, mainly in the respiratory tract (airsac and sinuses), prior to day 7 after inoculation. During clinical disease, chickens shed high virus titres orally and cloacally. Ducks intermittently shed low virus titres from the oral route for up to 8 days post-inoculation. We discuss the significance of the data for understanding the pathogenesis and pathobiology of Indonesian H5N1 in chickens and ducks. © 2012. Source

Dharmayanti N.L.P.I.,Indonesian Research Center for Veterinary Science | Hartawan R.,Indonesian Research Center for Veterinary Science | Pudjiatmoko,Ministry of Agriculture | Wibawa H.,Disease Investigation Center Wates | And 5 more authors.
Emerging Infectious Diseases | Year: 2014

After reports of unusually high mortality rates among ducks on farms in Java Island, Indonesia, in September 2012, influenza A(H5N1) viruses were detected and characterized. Sequence analyses revealed all genes clustered with contemporary clade viruses, rather than enzootic clade 2.1.3 viruses, indicating the introduction of an exotic H5N1 clade into Indonesia. Source

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