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Cambridge, MA, United States

Ahn S.,Sogang University | Deravi L.F.,Disease Biophysics Group | Park S.-J.,Disease Biophysics Group | Dabiri B.E.,Disease Biophysics Group | And 3 more authors.
Advanced Materials | Year: 2015

Spontaneous, highly ordered large-scale fibronectin networks driven by electrostatic polymer patterns are fabricated, and these precisely controlled protein connections are demonstrated. It is examined whether this scheme, universal to various fibrillar extracellular matrix proteins beyond fibronectin, collagen, and laminin, can be self-organized. These data reveal a novel bottom-up method to form anisotropic, free-standing protein networks to be used as flexible, transferrable substrates for cardiac and neuronal tissue engineering. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Mosadegh B.,Wyss Institute for Biologically Inspired Engineering | Mosadegh B.,Harvard University | Dabiri B.E.,Wyss Institute for Biologically Inspired Engineering | Dabiri B.E.,Disease Biophysics Group | And 9 more authors.
Advanced Healthcare Materials | Year: 2014

In vitro models of ischemia have not historically recapitulated the cellular interactions and gradients of molecules that occur in a 3D tissue. This work demonstrates a paper-based 3D culture system that mimics some of the interactions that occur among populations of cells in the heart during ischemia. Multiple layers of paper containing cells, suspended in hydrogels, are stacked to form a layered 3D model of a tissue. Mass transport of oxygen and glucose into this 3D system can be modulated to induce an ischemic environment in the bottom layers of the stack. This ischemic stress induces cardiomyocytes at the bottom of the stack to secrete chemokines which subsequently trigger fibroblasts residing in adjacent layers to migrate toward the ischemic region. This work demonstrates the usefulness of patterned, stacked paper for performing in vitro mechanistic studies of cellular motility and viability within a model of the laminar ventricle tissue of the heart. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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