Liu J.-J.,Discovery Chemistry |
Higgins B.,Discovery Oncology |
Ju G.,Discovery Oncology |
Kolinsky K.,Discovery Oncology |
And 8 more authors.
ACS Medicinal Chemistry Letters | Year: 2013
A new series of 7,8-disubstituted pyrazolobenzodiazepines based on the lead compound 1 have been synthesized and evaluated for their effects on mitosis and angiogenesis. Described herein is the design, synthesis, SAR, and antitumor activity of these compounds leading to the identification of R1530, which was selected for clinical evaluation. © 2013 American Chemical Society.