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Hall K.L.,U.S. National Cancer Institute | Stokols D.,University of California at Irvine | Stipelman B.A.,U.S. National Cancer Institute | Vogel A.L.,SAIC | And 6 more authors.
American Journal of Preventive Medicine | Year: 2012

Background: Large cross-disciplinary scientific teams are becoming increasingly prominent in the conduct of research. Purpose: This paper reports on a quasi-experimental longitudinal study conducted to compare bibliometric indicators of scientific collaboration, productivity, and impact of center-based transdisciplinary team science initiatives and traditional investigator- initiated grants in the same field. Methods: All grants began between 1994 and 2004 and up to 10 years of publication data were collected for each grant. Publication information was compiled and analyzed during the spring and summer of 2010. Results: Following an initial lag period, the transdisciplinary research center grants had higher overall publication rates than the investigator-initiated R01 (NIH Research Project Grant Program) grants. There were relatively uniform publication rates across the research center grants compared to dramatically dispersed publication rates among the R01 grants. On average, publications produced by the research center grants had greater numbers of coauthors but similar journal impact factors compared with publications produced by the R01 grants. Conclusions: The lag in productivity among the transdisciplinary center grants was offset by their overall higher publication rates and average number of coauthors per publication, relative to investigator-initiated grants, over the 10-year comparison period. The findings suggest that transdisciplinary center grants create benefits for both scientific productivity and collaboration.

Ames N.J.,U.S. National Institutes of Health | Sulima P.,National Institute of Dental and Craniofacial Research | Sulima P.,Discovery Logic | Ngo T.,U.S. National Institutes of Health | And 7 more authors.
PLoS ONE | Year: 2012

Background: The mouth is a complex biological structure inhabited by diverse bacterial communities. The purpose of this study is to describe the effects of allogeneic stem cell transplantation on the oral microbiota and to examine differences among those patients who acquired respiratory complications after transplantation. Methodology/Principal Findings: All patients were consented at the National Institutes of Health, Clinical Center. Bacterial DNA was analyzed from patients' oral specimens using the Human Oral Microbe Identification Microarray. The specimens were collected from four oral sites in 45 allogeneic transplantation patients. Specimens were collected at baseline prior to transplantation, after transplantation at the nadir of the neutrophil count and after myeloid engraftment. If respiratory signs and symptoms developed, additional specimens were obtained. Patients were followed for 100 days post transplantation. Eleven patients' specimens were subjected to further statistical analysis. Many common bacterial genera, such as Streptococcus, Veillonella, Gemella, Granulicatella and Camplyobacter were identified as being present before and after transplantation. Five of 11 patients developed respiratory complications following transplantation and there was preliminary evidence that the oral microbiome changed in their oral specimens. Cluster analysis and principal component analysis revealed this change in the oral microbiota. Conclusions/Significance: After allogeneic transplantation, the oral bacterial community's response to a new immune system was not apparent and many of the most common core oral taxa remained unaffected. However, the oral microbiome was affected in patients who developed respiratory signs and symptoms after transplantation. The association related to the change in the oral microbiota and respiratory complications after transplantation will be validated by future studies using high throughput molecular methods.

Mason J.L.,U.S. National Cancer Institute | Lei M.,U.S. National Cancer Institute | Faupel-Badger J.M.,U.S. National Cancer Institute | Ginsburg E.P.,U.S. National Cancer Institute | And 4 more authors.
Journal of Cancer Education | Year: 2013

The National Cancer Institute (NCI) career development (K) awards program supports investigators to develop their cancer research programs and achieve independence. The NCI Center for Cancer Training conducted a K program evaluation by analyzing outcomes of awardees and individuals who applied to the program but were not funded. The evaluation covered seven NCI mechanisms (K01, K07, K08, K11, K22, K23, and K25) between 1980 and 2008. Descriptive statistics and regression modeling were performed on the full cohort (n = 2,893 individuals, 4,081 K applications) and a comparison cohort described herein. K awardees proportionately received more subsequent NIH grants and authored more publications, and time to first R01 grant was unaffected. Of those not pursuing research, K awardees were more likely to participate in activities signaling continued scientific engagement. The NCI K program had a positive impact, not only on participants' biomedical research careers but also on achieving outcomes significant to the scientific enterprise. © 2013 The Author(s).

Ginther D.K.,University of Kansas | Haak L.L.,Discovery Logic | Schaffer W.T.,U.S. National Institutes of Health | Kington R.,U.S. National Institutes of Health | Kington R.,Grinnell College
Academic Medicine | Year: 2012

PURPOSE: To analyze the relationship among National Institutes of Health (NIH) R01 Type 1 applicant degree, institution type, and race/ethnicity, and application award probability. METHOD: The authors used 2000-2006 data from the NIH IMPAC II grants database and other sources to determine which individual and institutional characteristics of applicants may affect the probability of applications being awarded funding. They used descriptive statistics and probit models to estimate correlations between race/ethnicity, degree (MD or PhD), and institution type (medical school or other institution), and application award probability, controlling for a large set of observable characteristics. RESULTS: Applications from medical schools were significantly more likely than those from other institutions to receive funding, as were applications from MDs versus PhDs. Overall, applications from blacks and Asians were less likely than those from whites to be awarded funding; however, among applications from MDs at medical schools, there was no difference in funding probability between whites and Asians, and the difference between blacks and whites decreased to 7.8%. The inclusion of human subjects significantly decreased the likelihood of receiving funding. CONCLUSIONS: Compared with applications from whites, applications from blacks have a lower probability of being awarded R01 Type 1 funding, regardless of the investigator's degree. However, funding probability is increased for applications with MD investigators and for those from medical schools. To some degree, these advantages combine so that applications from black MDs at medical schools have the smallest difference in funding probability compared with those from whites.

Dores M.R.,Northwestern University | Schnell J.D.,Northwestern University | Schnell J.D.,Discovery Logic | Maldonado-Baez L.,Johns Hopkins University | And 2 more authors.
Traffic | Year: 2010

The formation of a primary endocytic vesicle is a dynamic process involving the transient organization of adaptor and scaffold proteins at the plasma membrane. Epsins and Eps15-like proteins are ubiquitin-binding proteins that act early in this process. The yeast epsins, Ent1 and Ent2, carry functional ubiquitin-interacting motifs (UIMs), whereas the yeast Eps15-like protein, Ede1, has a C-terminal ubiquitin-associated (UBA) domain. Analysis of mutants lacking early endocytic adaptors reveals that the ubiquitin-binding domains (UBDs) of Ent2 and Ede1 are likely to function primarily to mediate protein-protein interactions between components of the early endocytic machinery. Cells that lack epsin and Ede1 UBDs are able to internalize activated, ubiquitinated receptors. Furthermore, under conditions in which epsin UIMs are important for receptor internalization, receptors internalized via both ubiquitin-dependent and ubiquitin-independent signals require the UIMs, indicating that UIM function is not restricted to ubiquitinated receptors. Epsin UIMs share function with non-UBD protein-protein interaction motifs in Ent2 and Ede1, and the Ede1 UBA domain appears to negatively regulate interactions between endocytic proteins. Together, our results suggest that the ubiquitin-binding domains within the yeast epsin Ent2 and Ede1 are involved in the formation and regulation of the endocytic network. © 2009 John Wiley & Sons A/S.

News Article | January 4, 2010

Thomson Reuters (NYSE: TRI) has acquired scientific analytics software provider Discovery Logic as the company looks to expand its content and services. Discovery Logic will be folded into Thomson Reuters’ Healthcare & Science business. Financial terms of the transaction were not disclosed. Rockville, MD-based Discovery Logic gathers information from scientific and related business databases, which are then used to provide background for R&D investment decisions. The move comes as Thomson Reuters has been working to broaden its financial and business information services, to build up its appeal to a general business audience, while strengthening specific verticals like its Legal and Tax & Accounting businesses, in addition to the Healthcare & Science unit. The acquisition of Discovery Logic comes just a month after Thomson Reuters closed on its acquisition of financial commentary start-up Breakingviews, which serves as another example of the company’s intentions to expand its web offerings. Release

News Article | January 5, 2010

Thomson Reuters is ringing in the New Year with an acquisition under its belt. The business news and information conglomerate is acquiring Discovery Logic, a company that provides customizable analytics and scientific research software. Discovery Logic will become part of the the healthcare and science business of Thomson Reuters. Financial terms of the deal were not disclosed. Thomson says that the acquisition of Discovery Logic will help boost its research analytics offerings and and will provide increased workflow and scientific software to academic, government, non-profit and commercial professionals. Discovery Logic developers a software, called ScienceWire that aids with developing decisions around scientific discoveries and data. The software also serves as a database management platform. Thomson Reuters also recently acquired Breakingviews, a site that provided commentary on UK and European breaking financial news. Thomson was rumored to have paid close to $18 million in cash for the site.

News Article | January 4, 2010

If the first business day of 2010 is a portent, those hoping for an active year on the tech mergers and acquisition front should be encouraged. San Francisco-based Seesmic, maker of social networking applications, announced today it had acquired, a service that enables users to simultaneously post updates to any of 50 social networks via e-mail, IM, text message and various third-party apps. Terms of the deal were not disclosed, but’s co-founders, Adam Duffy and Sean McCullough, will be joining Seesmic’s management team. Seesmic also gets’s 500,000 users, who post some 200,000 updates daily and will help Seesmic toward its goal of conveying a million status updates a day by later this year. Also doing some post-holiday shopping was business news and information outfit Thomson Reuters, which announced today it had shelled out an undisclosed amount for Discovery Logic, a company that provides customizable analytics and decision support solutions for scientific research. The acquisition will be integrated into Thomson Reuters’ Healthcare & Science unit.

News Article | November 2, 2010

Reuters (NYSE: TRI) has acquired Highline Financial, a site that provides analytics about banking industry trends. The news service has made a few other similar acquisitions over the past year, including its January purchase of scientific analytics software provider Discovery Logic. Terms of the deal, which was managed by The Jordan, Edmiston Group, Inc. on behalf of Highline, was not disclosed. As Wall St. has experienced something of a comeback this year, as the severe impact of the global financial meltdown has receded, Reuters has been working on building up its subscription business to traders and investment banks. Reuters plans to incorporate Highline’s database info and other tools into its Eikon system, a desktop data and news offering available to financial companies that was launched in September. Among other things, the Thomson Reuters Eikon applies social media and mobility to the mix of market information, news, analytics and trading tools as part of its financial markets data subscription business.

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