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Rockville, MD, United States

Hall K.L.,U.S. National Cancer Institute | Stokols D.,University of California at Irvine | Stipelman B.A.,U.S. National Cancer Institute | Vogel A.L.,SAIC | And 6 more authors.
American Journal of Preventive Medicine | Year: 2012

Background: Large cross-disciplinary scientific teams are becoming increasingly prominent in the conduct of research. Purpose: This paper reports on a quasi-experimental longitudinal study conducted to compare bibliometric indicators of scientific collaboration, productivity, and impact of center-based transdisciplinary team science initiatives and traditional investigator- initiated grants in the same field. Methods: All grants began between 1994 and 2004 and up to 10 years of publication data were collected for each grant. Publication information was compiled and analyzed during the spring and summer of 2010. Results: Following an initial lag period, the transdisciplinary research center grants had higher overall publication rates than the investigator-initiated R01 (NIH Research Project Grant Program) grants. There were relatively uniform publication rates across the research center grants compared to dramatically dispersed publication rates among the R01 grants. On average, publications produced by the research center grants had greater numbers of coauthors but similar journal impact factors compared with publications produced by the R01 grants. Conclusions: The lag in productivity among the transdisciplinary center grants was offset by their overall higher publication rates and average number of coauthors per publication, relative to investigator-initiated grants, over the 10-year comparison period. The findings suggest that transdisciplinary center grants create benefits for both scientific productivity and collaboration. Source

Ginther D.K.,University of Kansas | Haak L.L.,Discovery Logic | Schaffer W.T.,U.S. National Institutes of Health | Kington R.,U.S. National Institutes of Health | Kington R.,Grinnell College
Academic Medicine | Year: 2012

PURPOSE: To analyze the relationship among National Institutes of Health (NIH) R01 Type 1 applicant degree, institution type, and race/ethnicity, and application award probability. METHOD: The authors used 2000-2006 data from the NIH IMPAC II grants database and other sources to determine which individual and institutional characteristics of applicants may affect the probability of applications being awarded funding. They used descriptive statistics and probit models to estimate correlations between race/ethnicity, degree (MD or PhD), and institution type (medical school or other institution), and application award probability, controlling for a large set of observable characteristics. RESULTS: Applications from medical schools were significantly more likely than those from other institutions to receive funding, as were applications from MDs versus PhDs. Overall, applications from blacks and Asians were less likely than those from whites to be awarded funding; however, among applications from MDs at medical schools, there was no difference in funding probability between whites and Asians, and the difference between blacks and whites decreased to 7.8%. The inclusion of human subjects significantly decreased the likelihood of receiving funding. CONCLUSIONS: Compared with applications from whites, applications from blacks have a lower probability of being awarded R01 Type 1 funding, regardless of the investigator's degree. However, funding probability is increased for applications with MD investigators and for those from medical schools. To some degree, these advantages combine so that applications from black MDs at medical schools have the smallest difference in funding probability compared with those from whites. Source

Dores M.R.,Northwestern University | Schnell J.D.,Northwestern University | Schnell J.D.,Discovery Logic | Maldonado-Baez L.,Johns Hopkins University | And 2 more authors.
Traffic | Year: 2010

The formation of a primary endocytic vesicle is a dynamic process involving the transient organization of adaptor and scaffold proteins at the plasma membrane. Epsins and Eps15-like proteins are ubiquitin-binding proteins that act early in this process. The yeast epsins, Ent1 and Ent2, carry functional ubiquitin-interacting motifs (UIMs), whereas the yeast Eps15-like protein, Ede1, has a C-terminal ubiquitin-associated (UBA) domain. Analysis of mutants lacking early endocytic adaptors reveals that the ubiquitin-binding domains (UBDs) of Ent2 and Ede1 are likely to function primarily to mediate protein-protein interactions between components of the early endocytic machinery. Cells that lack epsin and Ede1 UBDs are able to internalize activated, ubiquitinated receptors. Furthermore, under conditions in which epsin UIMs are important for receptor internalization, receptors internalized via both ubiquitin-dependent and ubiquitin-independent signals require the UIMs, indicating that UIM function is not restricted to ubiquitinated receptors. Epsin UIMs share function with non-UBD protein-protein interaction motifs in Ent2 and Ede1, and the Ede1 UBA domain appears to negatively regulate interactions between endocytic proteins. Together, our results suggest that the ubiquitin-binding domains within the yeast epsin Ent2 and Ede1 are involved in the formation and regulation of the endocytic network. © 2009 John Wiley & Sons A/S. Source

News Article | January 4, 2010
Site: gigaom.com

Thomson Reuters (NYSE: TRI) has acquired scientific analytics software provider Discovery Logic as the company looks to expand its content and services. Discovery Logic will be folded into Thomson Reuters’ Healthcare & Science business. Financial terms of the transaction were not disclosed. Rockville, MD-based Discovery Logic gathers information from scientific and related business databases, which are then used to provide background for R&D investment decisions. The move comes as Thomson Reuters has been working to broaden its financial and business information services, to build up its appeal to a general business audience, while strengthening specific verticals like its Legal and Tax & Accounting businesses, in addition to the Healthcare & Science unit. The acquisition of Discovery Logic comes just a month after Thomson Reuters closed on its acquisition of financial commentary start-up Breakingviews, which serves as another example of the company’s intentions to expand its web offerings. Release

News Article | January 5, 2010
Site: techcrunch.com

Thomson Reuters is ringing in the New Year with an acquisition under its belt. The business news and information conglomerate is acquiring Discovery Logic, a company that provides customizable analytics and scientific research software. Discovery Logic will become part of the the healthcare and science business of Thomson Reuters. Financial terms of the deal were not disclosed. Thomson says that the acquisition of Discovery Logic will help boost its research analytics offerings and and will provide increased workflow and scientific software to academic, government, non-profit and commercial professionals. Discovery Logic developers a software, called ScienceWire that aids with developing decisions around scientific discoveries and data. The software also serves as a database management platform. Thomson Reuters also recently acquired Breakingviews, a site that provided commentary on UK and European breaking financial news. Thomson was rumored to have paid close to $18 million in cash for the site.

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