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Indianapolis, IN, United States

Burkholder T.P.,Discovery Chemistry Research and Technology | Cunningham B.E.,Discovery Chemistry Research and Technology | Clayton J.R.,Discovery Chemistry Research and Technology | Lander P.A.,Discovery Chemistry Research and Technology | And 15 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

The design, synthesis, and structure activity relationships for a novel series of indoles as potent, selective, thyroid hormone receptor β (TRβ) agonists is described. Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo. © 2015 Elsevier Ltd. All rights reserved. Source

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