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Milan, United States

Ricci G.,RSA Villa San Clemente | Cosso P.,RSA Villa San Clemente | Pagliari P.,RSA Villa San Clemente | Ianes A.B.,Direzione Medica
Giornale di Gerontologia

Lower urinary tract infections (LUTIs) represent, with lower respiratory tract infections, the most common infections in geriatric population. Their diagnosis and treatment have implications for the health of patients, for the development of antibiotic resistance and for the costs associated with the diagnosis and therapy. Given the frequency of LUTIs, we wanted to check what are, in elderly patients living in nursing home, the most frequent pathogens of lower urinary tract infection. We performed an observational study by monitoring LUTIs in elderly people living in RSA Villa San Clemente, a 110 beds nursing home (Villasanta, MB). During the 54 months of follow up, we collected urine specimens within the first 48 hours from the admission, in case of urinary symptoms or, in the absence of symptoms, whenever it should become necessary a control of blood chemistry (at least once every 6 months) and urinary culture were obtained. During the follow up 708 positive urinary cultures in 185 subjects (mean age = 84,05 ± 7.72 years) were recorded; we registered 382 urinary infections in 139 women (253 = asymptomatic batteriuria) and 170 urinary infections in 46 men (73 = asymptomatic batteriuria). Gram negative strains were the most frequently isolated: Escherichia Coli (57.20%), Proteus Mirabilis (12.99%), Klebsiella Pneumoniae (9.60%), Pseudomonas Aeruginosa (4.09%). Among the gram positive strains, the more frequently isolated were Group D Streptococcus (1.84%), Enterococcus Faecalis (1.27%) and Coagulase Positive Staphylococcus (1.13%). Our data are consistent with those of the literature and confirm the importance of the surveillance of LUTIs also in nursing homes to identify subjects with symptomatic LUTIs or asymptomatic batteriuria, to better manage pharmaceutical expenditure avoiding inappropriate antibiotic treatment, and simultaneously treat symptomatic subjects to reduce the prevalence of recurrent infections and mortality in frail elderly. Source

Giampieri F.,Marche Polytechnic University | Alvarez-Suarez J.M.,Marche Polytechnic University | Mazzoni L.,Marche Polytechnic University | Romandini S.,Marche Polytechnic University | And 8 more authors.
Natural Product Research

The strawberry (Fragaria X ananassa, Duch.) represents a relevant source of micronutrients, such as minerals, vitamin C, folate and phenolic substances, most of which are natural antioxidants and contribute to the high nutritional quality of the fruit. All these compounds are essential for health and, in particular, strawberry phenolics are best known for their antioxidant and anti-inflammatory action, and possess directly and indirectly antimicrobial, anti-allergy and antihypertensive properties, as well as the capacity to inhibit the activities of some physiological enzymes and receptor properties. The main objective of this article is to review and update the current knowledge on the potential impact of the strawberry on human health, with particular attention on compounds and their possible mechanisms of action. © 2013 Taylor & Francis. Source

Introduction. Pain is a widespread condition among Nursing Home residents, but is under diagnosed and undertreated. Aim of the study was to evaluate, in ten nursing homes of Segesta, Korian Group, the willingness to recognize and to treat the symptom pain, testing the most commonly used molecules for the treatment of pain. We evaluated in a sample of nursing home residents, socio-demographic characteristics (sex, age and years of education), cognitive performance, affective disorders and diseases according to the 14 classes of Cumulative Illness Rating Scale. We further investigated chronic analgesic therapies (> 30 days), acute (< 30 days) and the most commonly molecules used as painkillers. Results. 1053 subjects were evaluated mainly represented by women [F = 800; (76%)], with a mean age of 83.45 ± 9.36, a 7.68 ± 4.10 years education and severe somatic co-morbidity. Pain treatment affected 306/1053 residents (29,1%), with a strong use of medicines as needed (25.2%). Chronic therapy involved the 12.8% of the subjects, the “acute” 4.5%. The most commonly used medication was acetaminophen, either in monotherapy (82.02%) than in pre-conceived association (18.94%), followed by opiates (22.54%) and NSAIDs (12,09%). Conclusions. Our data have confirmed the undertreatment of pain, especially in persistent pain. These data are in line with those of the literature. The most commonly used drugs were acetaminophen and opioids, limited the use of NSAIDs, while negligible the use of COX2 inhibitors. © 2014, Pacini Editore S.p.A. All rights reserved. Source

Rondanelli M.,University of Pavia | Monteferrario F.,University of Pavia | Faliva M.A.,University of Pavia | Perna S.,University of Pavia | Antoniello N.,Direzione Medica
Journal of the Science of Food and Agriculture

According to the American Diabetes Association and the Adult Treatment Panel III, the starting point for treating metabolic syndrome (MS) is a change of lifestyle. In addition, action on the main symptoms of MS by means of dietary supplements, can be helpful in view of the chronic course of the disease. The term 'phytosterols' refers to sterols and stanols composed of lipophilic triterpenes, a family that is widely distributed in the plant kingdom and whose cholesterol-lowering properties have been amply demonstrated. In the light of the recent literature, the key points for maximum effectiveness and safety of sterols are the following. (A) Plant sterols should be taken with meals: clinical trials have shown that when plant sterols are consumed close to mealtimes, low-density lipoprotein cholesterol may decrease by 9.4%, while when they are taken between meals, the reduction is about 6%. (B) The optimal dosage is 2-2.5 g day-1 in a single dose. More than 3 g day-1 has not been found to have any additional beneficial effect and increases the risk of side effects. (C) The food matrix used to dissolve the phytosterols should contain a certain amount of fat. A milk-based matrix appears optimal from this point of view. © 2013 Society of Chemical Industry. Source

Urinary tract infections (UTI) are the most common infection in institutionalized elderly. The issue of empirical treatment of infections is of great importance in elderly residents of nursing homes where the high incidence of UTI is associated with very high resistance rates. Aim of the work was to verify which of the antibiotics included in the routine susceptibility testing performed by our reference laboratory, could allow an empirical treatment of UTI, based on the sensitivity of strain susceptibility. We conducted a 54 months active surveillance of urinary tract infections in RSA Villa San Clemente Villasanta (MB), recording the sensitivity to each antibiotic, evaluated in a qualitative way ("S" Susceptible; "MS" moderately susceptible; "R" resistant). Data were accrued about 19 antibiotics, but only eight of them tested in more than 90% of cases and were considered for statistical analysis. Among the antibiotics evaluated, only imipenem-ciclastina appeared to be sufficiently reliable in case of empirical treatment. However considering route of administration, possible emergence of resistance and the high cost, we believe that assessment of urine culture with susceptibility testing remains the most effective and safe strategy for the choice of antibiotics for UTI in elderly residents of nursing home. Source

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