Directorate of Research and Studies

Muscat, Oman

Directorate of Research and Studies

Muscat, Oman

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El Aty M.A.,Directorate of Research and Studies | Meky F.A.,Ain Shams University | Morsy M.,Directorate of Research and Studies | El Sayed M.K.,Ministry of Health
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ | Year: 2014

Abstract available from the publisher.Despite the good health status of women and children in Oman, there are still some gaps to be filled. This study explored the adequacy of antenatal care (ANC) utilization of Omani ever-married women and the sociodemographic and health service determinants of adequate and sufficient ANC. In a secondary analysis of a national dataset (N = 1852 women), the percentages of women who had 4+ ANC visits, attended ANC in the 1st trimester and received care by trained personnel were 96.8%, 74.9% and 99.1% respectively. Overall adequacy of ANC (use and sufficiency of recommended basic services) for the surveyed women was 53.8%. After adjustment of other covariates, being pregnant with the 1st baby was the only significant predictor of overall adequacy of ANC (OR 2.2; 95% CI: 1.6-3.2). Greater awareness of the need for adequate ANC is required for mothers with more than one baby.Abstract available from the publisher.


PubMed | Directorate of Research and Studies, Ain Shams University and Ministry of Health
Type: Journal Article | Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit | Year: 2015

Despite the good health status of women and children in Oman, there are still some gaps to be filled. This study explored the adequacy of antenatal care (ANC) utilization of Omani ever-married women and the sociodemographic and health service determinants of adequate and sufficient ANC. In a secondary analysis of a national dataset (N = 1852 women), the percentages of women who had 4+ ANC visits, attended ANC in the 1st trimester and received care by trained personnel were 96.8%, 74.9% and 99.1% respectively. Overall adequacy of ANC (use and sufficiency of recommended basic services) for the surveyed women was 53.8%. After adjustment of other covariates, being pregnant with the 1st baby was the only significant predictor of overall adequacy of ANC (OR 2.2; 95% CI: 1.6-3.2). Greater awareness of the need for adequate ANC is required for mothers with more than one baby.


Al-Mawali A.,Directorate of Research and Studies | Pinto A.D.,Directorate of Research and Studies | Al Busaidi R.,The Royal Hospital | Al-Zakwani I.,Sultan Qaboos University
Cytometry Part A | Year: 2013

Country-specific reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries around the world; however, there have been no specific comprehensive studies in the Gulf Cooperation Council (GCC) and Middle East, which investigated age and gender-specific reference ranges. Demographic and environmental factors may contribute to variations in these subsets around the world, and thus there is a great necessity for each country to establish its own reference ranges. Hence, the aim of this study is to establish lymphocyte subsets reference ranges for Omani healthy adults. Total, age, and gender-specific reference ranges were established using four-color flow cytometry analysis with an extensive panel of monoclonal antibodies in 50 healthy adult males and females aged between 18 and 57. Reference values were expressed as median and 95% confidence intervals for T cells-CD3+: 76.5 (57-89), CD4+: 45 (31-58), CD5+: 75 (58-85), CD7+: 80 (70-89), CD8+: 29.5 (19-43); B cells-CD10+: 1 (1-3), CD19+: 14 (6-23), CD20+: 14 (6-23), and NK cells-CD16+: 9 (3-22), CD56+: 13 (5-24), CD3-/(CD16+/CD56+): 7 (3-20). In comparison with other published studies, the lymphocyte subsets reference ranges in healthy Omani adults were similar to those reported in the rest of the world. These observations have important clinical implications in lymphocyte subset analysis in Oman, especially in the management of immunological disorders. The reference ranges established by this study can be adopted as a reference for clinical practice decisions. © 2013 International Society for Advancement of Cytometry.


Al Riyami A.,Directorate of Research and Studies | Al Hadabi S.,Directorate of Health Services | Abd El Aty M.A.,Directorate of Research and Studies | Al Kharusi H.,Directorate of Research and Studies | And 2 more authors.
Eastern Mediterranean Health Journal | Year: 2010

The nutritional needs of the ageing population require special attention. We undertook a crosssectional, community-based, household survey in Nizwa wilayat, Oman to study nutrition-related knowledge and beliefs and self-reported dietary habits among a sample of elderly people. The response rate for the household interview was 99.3% from a total sample of 2041. About 45% of the elderly were overweight or obese. Overall we found poor knowledge of nutrition plus some nutritional imbalances and low levels of physical activity. Significant sex differences existed in elderly peoples' nutritional knowledge, consumption of fluids, milk and sweets, use of dietary regimens and experience of appetite change. The findings warrant reorientation of the existing health promotion strategy for the elderly.


PubMed | Directorate of Research and Studies
Type: Journal Article | Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology | Year: 2013

Country-specific reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries around the world; however, there have been no specific comprehensive studies in the Gulf Cooperation Council (GCC) and Middle East, which investigated age and gender-specific reference ranges. Demographic and environmental factors may contribute to variations in these subsets around the world, and thus there is a great necessity for each country to establish its own reference ranges. Hence, the aim of this study is to establish lymphocyte subsets reference ranges for Omani healthy adults. Total, age, and gender-specific reference ranges were established using four-color flow cytometry analysis with an extensive panel of monoclonal antibodies in 50 healthy adult males and females aged between 18 and 57. Reference values were expressed as median and 95% confidence intervals for T cells-CD3(+) : 76.5 (57-89), CD4(+) : 45 (31-58), CD5(+) : 75 (58-85), CD7(+) : 80 (70-89), CD8(+) : 29.5 (19-43); B cells-CD10(+) : 1 (1-3), CD19(+) : 14 (6-23), CD20(+) : 14 (6-23), and NK cells-CD16(+) : 9 (3-22), CD56(+) : 13 (5-24), CD3(-) /(CD16(+) /CD56(+) ): 7 (3-20). In comparison with other published studies, the lymphocyte subsets reference ranges in healthy Omani adults were similar to those reported in the rest of the world. These observations have important clinical implications in lymphocyte subset analysis in Oman, especially in the management of immunological disorders. The reference ranges established by this study can be adopted as a reference for clinical practice decisions.


PubMed | Directorate of Research and Studies
Type: Journal Article | Journal: Oman medical journal | Year: 2013

Constitutive activation of the fms-like tyrosine kinase 3 (FLT3) receptor by internal tandem duplication (ITD) of the juxtamembrane region has been described in patients with acute myeloid leukemia. FLT3/ITDs are present in about 20-30% of all acute myeloid leukemia cases. It has been shown that the mutation is correlated with worse prognosis. However, none of the previous studies investigated which FAB subtype is associated with higher percentage of FLT3/ITD, thus the reason for undertaking the current study.The prevalence and the potential prognostic impact of FLT3 mutations in 39 acute myeloid leukemia patients were analyzed by genomic polymerase chain reaction. Twelve samples with FLT3/ITDs and 27 acute myeloid leukemia samples without the mutations were compared with respect to clinical prognosis and FAB subtype. Results were correlated with cytogenetic data and the clinical response.FLT3/ITD mutations were found in 31% of patients. FLT3/ITD was associated with similar clinical characteristics and was more prevalent in patients with normal karyotype (83%). Interestingly, half of the FLT3/ITD aberrations were found in patients with FAB M1 (50%), and fewer were found in patients with FAB M2 (8%), M4 (8%), and M5 (8%). Although less frequent in patients with cytogenetic aberrations, FLT3/ITDs were found in 17% of patients with t(15;17). Although the study was powered to 80%, patients with FLT3/ITD mutation did not show shorter complete remission duration or a higher relapse rate.The data confirm that FLT3/ITD mutations represent a common alteration in adult acute myeloid leukemia, mainly with normal karyotype (83%) and de novo acute myeloid leukemia (75%), as compared to secondary acute myeloid leukemia (25%) (p<0.001). It also showed that half of the M1-FAB subtype is FLT3/ITD positive. Therefore, FLT3/ITD is a therapeutic target, and thus inhibition of FLT3 tyrosine kinase activity may provide a new approach in the treatment of leukemia carrying these mutations.


PubMed | Directorate of Research and Studies
Type: Journal Article | Journal: Oman medical journal | Year: 2012

The Oman World Health Survey (OWHS) is community-based household survey conducted in first half of 2008 for Omani and non-Omani population aged 18 years and above. It is a part of the World Health Survey (WHS) series which was developed by the World Health Organization (WHO) as a means to compile comprehensive information on the health of populations in different countries. A multi-stage stratified cluster sampling was designed to select about 5000 eligible subjects 18 years and above. The main objectives of the survey were to determine the national prevalence of Hypertension, Diabetes Mellitus, Obesity, Lipoproteins, Anemia, Visual ability and Cognitive functions. Among Omanis, the prevalence of Hypertension (40.3%), Diabetes Mellitus (12.3%), Obesity using BMI (24.1%), Total cholesterol (33.6%), Anemia in males 20% and in non-pregnant females was 32.2%. In Oman, the increase in lifestyle-related non communicable diseases has emerged as new health challenges to the country which need to be addressed.

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