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Al-Azzawi H.M.A.,Directorate of Research and Nuclear Applications | Al-Nuzal S.M.D.,University of Technology, Iraq | Badi J.M.,Directorate of Research and Nuclear Applications
Journal of Radioanalytical and Nuclear Chemistry

This work is concerned on establishing the necessary comparative quality control biological parameters for the evaluation of locally produced renal pharmaceutical preparations viz. tin complexes of 99mTc-DTPA, 99mTc-GH, and 99mTc-DMSA using gel chromatography column scanning techniques. Radiochemical purity, labeling yields, organ distribution, blood clearance and plasma protein binding were used as a selected indicator for quality control. The higher renal accumulation and tissue distribution were apparent with 99mTc-DTPA in mice, while blood retention was considerably low. The blood clearance of 99mTc-DMSA was relatively slow, while that of 99mTc-GH was rapid. The binding of 99mTc-DTPA, 99mTc-GH and 99mTc-DMSA with plasma protein were found to be 5, 65, and 95 % at 1.0 h, respectively. The stability of these cold kits was not affected on storing at 37 °C for 30 days. © 2015, Akadémiai Kiadó, Budapest, Hungary. Source

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