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Al-Azzawi H.M.A.,Directorate of Research and Nuclear Applications | Al-Nuzal S.M.D.,University of Technology, Iraq | Badi J.M.,Directorate of Research and Nuclear Applications
Journal of Radioanalytical and Nuclear Chemistry | Year: 2016

This work is concerned on establishing the necessary comparative quality control biological parameters for the evaluation of locally produced renal pharmaceutical preparations viz. tin complexes of 99mTc-DTPA, 99mTc-GH, and 99mTc-DMSA using gel chromatography column scanning techniques. Radiochemical purity, labeling yields, organ distribution, blood clearance and plasma protein binding were used as a selected indicator for quality control. The higher renal accumulation and tissue distribution were apparent with 99mTc-DTPA in mice, while blood retention was considerably low. The blood clearance of 99mTc-DMSA was relatively slow, while that of 99mTc-GH was rapid. The binding of 99mTc-DTPA, 99mTc-GH and 99mTc-DMSA with plasma protein were found to be 5, 65, and 95 % at 1.0 h, respectively. The stability of these cold kits was not affected on storing at 37 °C for 30 days. © 2015, Akadémiai Kiadó, Budapest, Hungary.

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