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Al-Nuzal S.M.D.,University of Technology, Iraq | Al-Azzawi H.M.A.-K.,Directorate of Chemistry and Petrochemical Industry | Al-Mosawy Z.M.J.,Directorate of Chemistry and Petrochemical Industry
Journal of Radioanalytical and Nuclear Chemistry

A new method to prepare novel semi-rigid multidentate ligands containing nitrogen atom, to coordinate with rhenium and technetium, was established. The method was based on formylation of substituted anilines, followed by Mannich reaction with glycine and paraformaldehyde. The method was very promising to design ligands of various molecular structures (L1-L5) to coordinate with rhenium metal ions. The complexes were prepared through ligand exchange with the complex ReOCl3(PPh3)2, giving new complex of the structure ReOCl3L(1-5). The prepared ligands and complexes were identified by the use of UV-vis, and infrared absorption spectrometric techniques, elemental analysis, molecular weight determination by depression of freezing point. These ligands were labeled with 99mTc pertechnetate, and the labeling efficiency of the complexes was measured using a well type scintillation gamma counter equipment and obtained a good yield. © 2012 The Author(s). Source

Al-Azzawi H.M.A.K.,Directorate of Chemistry and Petrochemical Industry | Al-Nuzal S.M.D.,University of Baghdad | Abas S.A.E.,Directorate of Chemistry and Petrochemical Industry | Ahmed S.S.,Directorate of Chemistry and Petrochemical Industry | And 2 more authors.
Journal of Radioanalytical and Nuclear Chemistry

The present investigation deals with a simple preparation of new formulation of tin-sucralfate freeze-dried kit (F.D.K.), to be directly labeled with 99mTc at optimal pH value of 7.0. The lyophilized form containing 100 mg sucralfate and 11.3 mg dihydrated stannous chloride. Other optimal pH values of the preparation were found to be from 4.0 to 11.0. The range of sucralfate amount studied (50-500 mg) not affected the radiochemical purity of the labeled complex. The radiochemical purity and the stability of the labeled preparation that assessed by filtration were more than 95%. 99mTc sucralfate was radiochemical stable up to a specific activity of 1,000 mCi per gram which was more stable than earlier published value (700 mCi per gram) without any radiolytic decomposition. The biological behavior of 99mTc-pertechnetate was evaluated in two groups of animals, the first group (neither fasted nor ulcerated) and the second group (fasted and ulcerated mice). The data of organ distribution of 99mTc-sucralfate in ulcerated fasted mice showed that more than 99% of the administered dose was accumulated in the stomach (87.92%) and intestine (11.43%). The radioanalytical results together with the in vivo-biological behavior of the labeled preparation demonstrate it's stability, efficacy and usefulness in medical applications for the detection of gastrointestinal ulcers. © 2012 Akadémiai Kiadó. Source

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