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Sarwar M.S.,University of Agriculture, Peshawar | Kalhoro A.B.,Sindh Agriculture University | Khan H.,University of Agriculture, Peshawar | Kausarzeb,Direct. General Ext Livestock and Dairy Development | And 5 more authors.
Pakistan Journal of Zoology | Year: 2014

An experimental study was carried out on nine rabbits to compare the sedative and analgesic effects and also to record some physiological effects of xylazine at three different intramuscular doses i.e. 6, 8 and 10 mg/kg body weight. Our results demonstrated that xylazine at 6 mg/kg produced medium sedation, whereas 8 and 10mg/kg of xylazine produced deep sedation in rabbits. In addition, the maximum skin analgesia occurred at 13.22±0.68 min with 10mg/kg body weight for the total duration of 56.55±0.76 min as against 23.77±0.79, 16.55±0.53 min for the total duration of 35.11±0.84, 15.88±0.44 min, 8 and 6 mg/kg, respectively. Furthermore, the current results demonstrated decrease in pulse rate, respiratory rate and body temperature in the experimental rabbits after 45, 60 and 75 min with 6, 8 and 10 mg/kg, respectively. Body temperature returned to base line after 75, 90 and 105 min with 6, 8 and 10mg/kg of body weight, respectively. On the other hand, some side effects such as salivation and tympany were observed after administration that were transient and did not pose any serious problem at any stage during the experiment. All side effects had returned to normal 120 min after administration. It can be deduced from the current study that xylazine is a potent and safe drug for sedation in rabbits. © 2014 Zoological Society of Pakistan. Source

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