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Angiulli F.,Dimes Inc | Basta S.,CNR Institute for High Performance Computing and Networking | Lodi S.,DISI | Sartori C.,DISI
Proceedings of the 2014 International Conference on High Performance Computing and Simulation, HPCS 2014 | Year: 2014

Outlier detection is a data mining task consisting in the discovery of observations which deviate substantially from the rest of the data, and has many important practical applications. Outlier detection in very large data sets is however computationally very demanding and the size limit of the data that can be elaborated is considerably pushed forward by mixing three ingredients: efficient algorithms, intra-cpu parallelism of high-performance architectures, network level parallelism. In this paper we propose an outlier detection algorithm able to exploit the internal parallelism of a GPU and the external parallelism of a cluster of GPU. The algorithm is the evolution of our previous solutions which considered either GPU or network level parallelism. We discuss a set of large scale experiments executed in a supercomputing facility and show the speedup obtained with varying number of nodes. © 2014 IEEE.


Fazzinga B.,CNR Institute for High Performance Computing and Networking | Flesca S.,Dimes Inc | Furfaro F.,Dimes Inc | Masciari E.,CNR Institute for High Performance Computing and Networking | Pontieri L.,CNR Institute for High Performance Computing and Networking
ACM International Conference Proceeding Series | Year: 2015

The increasing availability of large process log repositories calls for efficient solutions for their analysis. In this regard, a novel specialized compression technique for process logs is proposed, that builds a synopsis supporting a fast estimation of aggregate queries, which are of crucial importance in exploratory and high-level analysis tasks. The synopsis is constructed by progressively merging the original log-Tuples, which represent single activity executions within the process instances, into aggregate tuples, summarizing sets of activity executions. The compression strategy is guided by a heuristic aiming at limiting the loss of information caused by summarization, while guaranteeing that no information is lost on the set of activities performed within the process instances and on the order among their executions. The selection conditions in an aggregate query are specified in terms of a graph pattern, that allows precedence relationships over activity executions to be expressed, along with conditions on their starting times, durations, and executors. The efficacy of the compression technique, in terms of capability of reducing the size of the log and of accuracy of the estimates retrieved from the synopsis, has been experimentally validated. © 2015 Copyright held by the owner/author(s).


PubMed | French Institute of Health and Medical Research, University of Turin, Instituto G Gaslini, CNRS Center for Molecular Biophysics and 2 more.
Type: Journal Article | Journal: Oncotarget | Year: 2016

As rapidly developing patient-derived xenografts (PDX) could represent potential sources of cancer stem cells (CSC), we selected and characterized non-cultured PDX cell suspensions from four different renal carcinomas (RCC). Only the cell suspensions from the serial xenografts (PDX-1 and PDX-2) of an undifferentiated RCC (RCC-41) adapted to the selective CSC medium. The cell suspension derived from the original tumor specimen (RCC-41-P-0) did not adapt to the selective medium and strongly expressed CSC-like markers (CD133 and CD105) together with the non-CSC tumor marker E-cadherin. In comparison, PDX-1 and PDX-2 cells exhibited evolution in their phenotype since PDX-1 cells were CD133high/CD105-/Ecadlow and PDX-2 cells were CD133low/CD105-/Ecad-. Both PDX subsets expressed additional stem cell markers (CD146/CD29/OCT4/NANOG/Nestin) but still contained non-CSC tumor cells. Therefore, using different cell sorting strategies, we characterized 3 different putative CSC subsets (RCC-41-PDX-1/CD132+, RCC-41-PDX-2/CD133-/EpCAMlow and RCC-41-PDX-2/CD133+/EpCAMbright). In addition, transcriptomic analysis showed that RCC-41-PDX-2/CD133- over-expressed the pluripotency gene ERBB4, while RCC-41-PDX-2/CD133+ over-expressed several tumor suppressor genes. These three CSC subsets displayed ALDH activity, formed serial spheroids and developed serial tumors in SCID mice, although RCC-41-PDX-1/CD132+ and RCC-41-PDX-2/CD133+ displayed less efficiently the above CSC properties. RCC-41-PDX-1/CD132+ tumors showed vessels of human origin with CSC displaying peri-vascular distribution. By contrast, RCC-41-PDX-2 originated tumors exhibiting only vessels of mouse origin without CSC peri-vascular distribution.Altogether, our results indicate that PDX murine microenvironment promotes a continuous redesign of CSC phenotype, unmasking CSC subsets potentially present in a single RCC or generating ex novo different CSC-like subsets.


Coradeghini R.,JRC European Commission Institute for Health and Consumer Protection | Guida C.,University of Genoa | Scanarotti C.,Dimes Inc | Sanguineti R.,Dimes Inc | And 4 more authors.
Cells Tissues Organs | Year: 2010

Human adipose-derived stem cells possess a lot of stem cell characteristics, so they may be considered a source of stem cell population. On the basis of that, we have investigated the hepatic potential of adipose-derived stem cells, obtained from liposuction, following two differentiation protocols. In the first procedure, medium was supplemented with epidermal growth factor (EGF), basic fibroblast growth factor, hepatocyte growth factor (HGF) and nicotinamide; the second involved the addition of factors such as dexametasone, EGF, insulin-transferrin-sodium selenite, HGF, dimethyl sulfoxide and oncostatin. In parallel, we carried out our study in the Hep G2 cell line, as human hepatic differentiated in vitro model. Immunocytochemical analysis and RT-PCR were performed using hepatic markers to evaluate cell differentiation. DNA content, MTT test and carboxyl fluorescein succinimidyl ester staining were carried out to evaluate cell proliferation. We reported the evidence of basal hepatic marker in undifferentiated adipose-derived stem cells, which confirmed their multipotency. A strong expression of albumin and α-fetoprotein was observed in hepatic-induced adipose-derived stem cells following both differentiation procedures. Morphological aspects of the two types of hepatic adipose-derived stem cells were alike. Proliferation index suggested that the first differentiation procedure promoted better growth than the second. These preliminary findings suggest adipose-derived stem cells may be induced into hepatic lineage, and the most significant difference between the two standard differentiation procedures concerns proliferation rate. This aspect is to be considered when adipose-derived stem cells are employed in research and clinical studies. Copyright © 2009 S. Karger AG, Basel.


Zhuang J.,AMD Inc | Waheed K.,Bitwave Inc. | Staszewski R.B.,Dimes Inc
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2010

A polar modulator for wireless RF transmitters nonlinearly transforms complex-valued Cartesian baseband modulating signal into amplitude and phase components of the polar coordinate representation before they are recombined in a power amplifier. The resulting explosion in the bandwidth requirements of the polar components can so far be only tolerated for narrowband transmitters, such as EDGE of the 2G cellular. To enable polar topology for wideband transmitters, we propose a technique that alters the signal trajectory such that it avoids crossing (and proximity) of the constellation origin. The resulting substantial decrease of the polar modulator bandwidth is traded off against slight increase of in-band modulation distortion and adjacent channel leakage. We illustrate effectiveness of this method using wideband CDMA (WCDMA) of the 3G cellular. The technique is first mathematically analyzed for various tradeoffs followed by high-level modeling and simulation results. Since the technique is fully contained in the digital domain, its performance effects on the entire RF transmitter can be accurately simulated. A digital architecture to implement the proposed technique is also presented. © 2006 IEEE.


Bogdan Staszewski R.,Dimes Inc
Proceedings - IEEE International Symposium on Circuits and Systems | Year: 2011

The past several years have successfully brought all-digital techniques to the RF frequency synthesis, which is used for frequency translation between the baseband and RF frequencies in wireless transmitters and receivers. Reference [1] has described the recent journey of digitizing RF frequency synthesizers, such that now they are amenable to nanoscale CMOS technology with area, power and performance metrics well exceeding those of the traditional charge-pump PLL's. This paper examines an important aspect of the all-digital frequency synthesizers, which takes on some of the transmitter functionality by allowing to directly perform the carrier frequency modulation. This is useful in today's wireless system, which either completely rely on the frequency modulation to convey the information or use it as part of a polar vector modulation. A novel multi-rate polar transmitter is proposed in which the modulating data rate is independent from the reference frequency. © 2011 IEEE.


Fazzinga B.,Dimes Inc | Flesca S.,Dimes Inc | Furfaro F.,Dimes Inc | Parisi F.,Dimes Inc
ACM International Conference Proceeding Series | Year: 2014

An offline cleaning technique is proposed for translating the readings generated by RFID-tracked moving objects into positions over a map. It consists in a grid-based two-way filtering scheme embedding a sampling strategy for addressing missing detections. The readings are first processed in time order: at each time point t, the positions (i.e., cells of a grid assumed over the map) compatible with the reading at t are filtered according to their reachability from the positions that survived the filtering for the previous time point. Then, the positions that survived the first filtering are re-filtered, applying the same scheme in inverse order. As the two phases proceed, a probability is progressively evaluated for each candidate position at each time point t: at the end, this probability assembles the three probabilities of being the actual position given the past and future positions, and given the reading at t. A sampling procedure is employed at certain steps of the first filtering phase to intelligently reduce the number of cells to be considered as candidate positions at the next steps, as their number can grow dramatically in the presence of consecutive missing detections. The proposed approach is experimentally validated and shown to be efficient and effective in accomplishing its task. © Copyright 2014 ACM 978-1-4503-2722-0/14/06⋯$15.00.


Polito L.,Dimes Inc | Bortolotti M.,Dimes Inc | Mercatelli D.,Dimes Inc | Battelli M.G.,Dimes Inc | Bolognesi A.,Dimes Inc
Toxins | Year: 2013

Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it has been widely employed in the construction of conjugates and immunotoxins for different purposes. These immunotoxins have shown many interesting results when used in cancer therapy, particularly in hematological tumors. The high enzymatic activity, stability and resistance to conjugation procedures and blood proteases make saporin-S6 a very useful tool in cancer therapy. High efficacy has been reported in clinical trials with saporin-S6-containing immunotoxins, at dosages that induced only mild and transient side effects, which were mainly fever, myalgias, hepatotoxicity, thrombocytopenia and vascular leak syndrome. Moreover, saporin-S6 triggers multiple cell death pathways, rendering impossible the selection of RIP-resistant mutants. In this review, some aspects of saporin-S6, such as the chemico-physical characteristics, the structural properties, its endocytosis, its intracellular routing and the pathogenetic mechanisms of the cell damage, are reported. In addition, the recent progress and developments of saporin-S6-containing immunotoxins in cancer immunotherapy are summarized, including in vitro and in vivo pre-clinical studies and clinical trials. © 2013 by the authors; licensee MDPI, Basel, Switzerland.


Trademark
Dimes Inc | Date: 2010-03-16

[ Meat, fish; Dry legumes; Ready soups; preserved olives; Milk and milk products excluding ice cream, ice milk and frozen yogurt; Edible vegetable oils; sesame oil, Eggs; Potato chips ]. [ Coffee, cocoa; beverages with chocolate base, namely, chocolate food beverages not being dairy-based or vegetable based; Macaronis, noodles; Honey, propolis, namely, bee glue for human consumption; Spices; Yeasts; flour, processed semolinas, food starches; Sugar powder, cube sugar, confectionery sugar, namely, crystal sugar pieces; Teas, ice teas; Candies for food, chocolates, biscuits, crackers, wafers; Salt ]. Beers; Mineral waters, spring waters, table waters, soda waters; Vegetable juices as beverages; fruit juices; syrups for making beverages, namely, for making vegetable and fruit beverages.


Trademark
Dimes Inc | Date: 2013-01-18

Alcoholic beverages excluding beers, namely, wines, liqueurs, cognacs, gins, whiskeys, raki (Turkish traditional anise flavored alcoholic beverage).

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