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PubMed | General Hospital of Didimoticho and National and Kapodistrian University of Athens
Type: Journal Article | Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | Year: 2016

Neurological complications involving the lumbar spine following intravenous injection of heroin was observed in a 28-year-old man. On admission, steroids were administrated, and the patient had a complete recovery after an interval of 2 days. There have been more than 46 cases reported in the literature with similar findings to the one presented here. The mechanism of neuropathology of heroin abuse is still unknown. Possible mechanisms are a toxic, allergic, or a hypersensitivity reaction. Rare cases of complete recovery have been reported.

Amarantidis K.,University General Hospital of Alexandroupolis | Xenidis N.,University General Hospital of Alexandroupolis | Chelis L.,University General Hospital of Alexandroupolis | Chamalidou E.,University General Hospital of Alexandroupolis | And 7 more authors.
Oncology | Year: 2011

Objective: In the present phase II study, we evaluated the efficacy and safety of a docetaxel-oxaliplatin-capecitabine combination as a first-line treatment in patients with advanced gastric cancer. Patients and Methods: A total of 27 patients (18 males) with histologically confirmed inoperable gastric adenocarcinoma were recruited. Docetaxel was given (50 mg/m 2 i.v.) on day 1 followed by oxaliplatin (75 mg/m 2 i.v.) also on day 1. Capecitabine (2,750 mg/m 2) was given orally as two daily divided doses from days 1 to 7. Cycles were repeated every 2 weeks. All patients had measurable disease and 18 of them had a performance status (WHO) of 0. Results: A total of 240 treatment cycles were administered. All patients were evaluable for toxicity. Four patients who discontinued treatment early (having received only 3 chemotherapy cycles) were included as non-responders in an intention-to-treat response analysis. Complete response, partial response, stable disease and progressive disease were observed in 4 (15%), 12 (44%), 3 (11%) and 8 (30%) patients, respectively. The observed response rate was 59%, and the disease control rate (complete response + partial response + stable disease) was 70%. At the time of analysis, 6 patients were still alive and the median survival was 18.0 months. The most common grade III/IV toxicities observed were neutropenia (5%), diarrhea (2%), palmar-plantar erythrodysesthesia (2%) and neurotoxicity (1%). All other toxicities were mostly of grade I/II and easily manageable. Conclusion: The combination of docetaxel, oxaliplatin and capecitabine in the described mode of administration represents a relatively active and well-tolerated regimen in patients with advanced gastric cancer and warrants further evaluation. Copyright © 2011 S. Karger AG, Basel.

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