Dibrugarh, India

Dibrugarh University

Dibrugarh, India

Dibrugarh University is a university in the Indian state of Assam. It was set up in 1965 under the provisions of the Dibrugarh University Act, 1965, enacted by the Assam Legislative Assembly. It is a teaching-cum-affiliating university with limited residential facilities. Wikipedia.

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Bhattacharya A.,Dibrugarh University
Current drug delivery | Year: 2010

Water soluble polysaccharides are currently finding increasing use as a basis material for plasma volume expander. In clinical setting it is desirable to have a precise knowledge of steric and chemical structure, since these affect the pharmacokinetics and pharmacology of plasma volume expander. Branch component of starch amylopectin is very similar in structure to glycogen, the reserve polysaccharide of animal and therefore is liable to be compatible with body tissue. The knowledge of weight average molecular mass, degree of branching, osmotic pressure and coil dimension are essential, since low molecular mass do not have desirable effect and large molar mass have undesirable effect. Assam Bora rice starch was characterized by polymer analysis for use as plasma volume expander. Characterization involves the determination of FTIR spectra, degree of branching by H1 NMR, osmotic pressure by internal measurement technique, establishment of Mark-Houwink relationship and determination of Molecular weight - viscosity relationship.

Leaves of Paederia foetida collected from three districts of Assam were analysed for phytochemical constituents, antioxidant and antimicrobial activity and nutrient content. Saponin, tannin, phenol, flavonoid, terpenoid, cardiac glycoside, alkaloid and reducing sugar were detected in the samples but steroid and anthraquinone were not detected. The order of total phenolic content, antioxidant activity and nutrient content of the samples were sample 1 > sample 3 > sample 2. Ethanolic extracts showed antimicrobial activity against Bacillus subtilis and Staphylococcus aureus with zones of inhibition ranging from 4 to 12 mm. The MIC test of the ethanolic extract against B. subtilis and S. aureus was observed as 1.25 mg/ml. Inhibitory effect of ethanolic extracts was more against B. subtilis but less against S. aureus than streptomycin and no inhibitory effect was noted against Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris. It is noted that both primary and secondary metabolite content of plants varies with variation of growing localities. © 2013, JPR Solutions.

Nandy B.C.,Dibrugarh University | Mazumder B.,Dibrugarh University
Current Drug Delivery | Year: 2014

Indomethacin is a widely used non-steroidal anti-inflammatory drug (NSAID) and extensively employed for treatment of arthritis. Delayed action (at the morning or night) is needed for arthritic patients. To improve the patient compliance, in this study we aimed to delay the drug release by designing multi-particulates system in the form of microspheres, which would efficiently release the drug into the colon and replace the conventional therapy. The aim of the present work was to elucidate the effect of formulation variables e.g., amount of eudragit polymer (X1), surfactant concentration (X2) and agitation speed (X3) on in-vitro release profiles (Y1-Y3), drug entrapment efficiency (Y4) and particle size (Y5) of multi-particulates system of indomethacin. Experiments were designed according to a three levels face centered central composite design. Microspheres were formulated with the combination of ethyl cellulose (EC) and Eudragit RS 100/Eudragit S100; by using a novel quasi emulsion solvent diffusion technique. Developed formulations were characterized and evaluated on the basis of FTIR, thermal, particle size, SEM, XRD analysis and drug release kinetics studies. The formulation variables were optimized by response surface methodology (RSM). It was found that in-vitro release (Y1-Y3) was decreased significantly (p<0.05) with increase in amount of eudragit polymer but increased significantly (p<0.05) with increase in surfactant concentration and stirring speed. It was observed that the drug release data of the selected formulation was similar to the predicted release pattern. FTIR study indicated that no prominent chemical interaction or changes took place between the drug and excipients of prepared formulations. DSC and XRD studies indicated that drug was present in the amorphous state and may have been homogenously dispersed into the polymers matrix. Therefore this approach suggested that the combination of EC and Eudragit S100 microspheres may be useful in a better way, for the delivery of maximum amount of indomethacin in intact form to the colon. © 2014 Bentham Science Publishers.

Sharma V.K.,Gurukul Kangri University | Mazumder B.,Dibrugarh University
International Journal of Biological Macromolecules | Year: 2014

Isabgol husk with sodium alginate was formulated into gliclazide loaded microparticles which were characterized for particle size, swelling index, entrapment efficiency, in vitro release, release kinetics, stability, hypoglycemic effect, surface morphology, and gastrointestinal transition. The particle size in different formulations varied from 752.83±0.630 to 872.03±0.293μm. It was analyzed by dissolution study that up to 98% of loaded gliclazide was released in simulated intestinal fluid (SIF, pH 7.4) within 8h. The formulations containing sodium alginate and Isabgol husk-sodium alginate showed bioequivalency with marketed sustained release tablets (Glizid MR 60®) in terms of release pattern. The drug maintained its integrity in terms of functional groups after fabrication in formulations as observed by FTIR analysis. The hypoglycemic effect of gliclazide loaded Isabgol husk-sodium alginate microparticles was found to be 37±6.356% in terms of changes of blood glucose level from base glucose level (100%) in diabetic condition after 24h of oral administration and it was more than marketed conventional tablets (95.5±3.286%). The retention of microparticles was observed in small intestine up to 10h during whole body X-ray imaging. The study revealed that microparticles composing of Isabgol husk may have the potential for regulating blood glucose level in diabetic animals with controlled release of gliclazide. © 2014 Elsevier B.V.

Mondal M.,Dibrugarh University | Bora U.,Dibrugarh University | Bora U.,Tezpur University
RSC Advances | Year: 2013

The preceding four decades have witnessed a major expansion in the field of free-radical assisted reactions, as they are becoming a key tool in organic, polymer and complex natural product chemistry. This progress has clearly changed the traditional idea of free-radical reactions being "extremely uncontrollable", thereby allowing chemists to deal with free radicals in a more accurate and controlled way. Manganese(iii) acetate mediated radical reactions have reached distinction in this field, as a wide range of protocols involving manganese(iii) acetate under mild and efficient reaction conditions have been developed for the synthesis of biologically active and important organic molecules through oxidation, addition and cyclization reactions, which are in general difficult to achieve by the established synthetic operations. The present review focuses on manganese(iii) acetate mediated oxidative free-radical reactions that have been developed and adapted during the last five years. It includes the advancements made in the field of free-radical promoted carbon-carbon and carbon-oxygen bond forming reactions, illustrating the examples of furans, hydrofurans, pyrroles, bicyclic lactones, biaryls, oxepins, indole-alkaloids, 1,2-benzanthracene and C60-fused tetrahydronaphthalene synthesis. Numerous manganese(iii) acetate initiated carbon-phosphorus bond formation reactions were also devised during recent years, involving both phosphonyl and phosphinoyl radicals, and are a key part of this review. Manganese(iii) acetate promotes functionalization of significant organic compounds, thereby guiding the synthesis of important and complex molecules, such as the formation of propellanes, quinolinones, 1,2-dioxalanes; oxidation of indoles; lactonization of fullerene [C60], malonyl cyclopentanes, glycols; and hydroperoxidation of heterocycles. The review will also envelop several recent milestones that have been achieved in the chemistry of natural products précising the vital role of manganese(iii) acetate in the key synthetic steps. This journal is © The Royal Society of Chemistry 2013.

Mondal M.,Dibrugarh University | Bora U.,Dibrugarh University
Green Chemistry | Year: 2012

An in situ generated catalytic system based on PdCl2 and sodium sulfate exhibited excellent catalytic activity in the Suzuki-Miyaura cross-coupling reactions of aryl halides with arylboronic acids at room temperature in water. A similar catalytic system can be obtained with PdCl 2 and sodium chloride or sodium acetate and is equally effective in Suzuki-Miyaura cross-coupling reactions. This method offers a mild and efficient alternative to the existing protocols since the reaction is proceeded in water at room temperature under ligand free conditions. © The Royal Society of Chemistry 2012.

Gogoi A.,Dibrugarh University | Bora U.,Dibrugarh University
Tetrahedron Letters | Year: 2013

An ipso-hydroxylation of arylboronic acids to phenols using aqueous H 2O2 as oxidant and acidic alumina as catalyst has been reported in this study. The reusability of the catalyst is also investigated. © 2013 Elsevier Ltd. All rights reserved.

Gogoi S.B.,Dibrugarh University
Transport in Porous Media | Year: 2011

Surfactant loss due to adsorption on the porous medium of an oil reservoir is a major concern in enhanced oil recovery. Surfactant loss due to adsorption on the reservoir rock weakens the effectiveness of the injected surfactant in reducing oil-water interfacial tension (IFT) and making the process uneconomical. In this study, surfactant concentrations in the effluent of the corefloods and oil-water IFT were determined under different injection strategies. It was found that in an extended waterflood following a surfactant slug injection, surfactant desorbed in the water phase. This desorbed surfactant lasted for a long period of the waterflood. The concentration of the desorbed surfactant in the extended waterflood was very low but still an ultralow IFT was obtained by using a suitable alkali. Coreflood results show an additional recovery of 13. 3% of the initial oil in place was obtained by the desorbed surfactant and alkali. Results indicate that by utilizing the desorbed surfactant during the extended waterflood operation the efficiency and economics of the surfactant flood can be improved significantly. © 2011 Springer Science+Business Media B.V.

Gogoi A.,Dibrugarh University | Bora U.,Dibrugarh University
Synlett | Year: 2012

A mild and efficient methodology for the ipso-hydroxylation of arylboronic acids to phenols has been developed using aqueous hydrogen peroxide as oxidizing agent and molecular iodine as catalyst. The reactions were performed at room temperature in short reaction time under metal-, ligand- and base-free conditions. © Georg Thieme Verlag Stuttgart · New York.

Singh A.V.,Dibrugarh University
Journal of Thermal Analysis and Calorimetry | Year: 2013

The present investigation concerns with thermal analysis of biomaterials such as Chitosan, Xanthan gum, Guar gum Pectin, Karaya gum, Sodium alginate, and Psyllium husk mucilage. The DSC curve of the natural polymers showed its specific endothermic peaks and ΔH f values, and these will be helpful in determining the fitness of the polymers with active drug. The drug and natural polymer compatibility study is now one of the recognized methods for preformulation step in pharmaceutical drug development. All the natural polymers showed endothermic peak below 150 C, and this make them suitable with a wide class of therapeutic drugs. © 2012 Akadémiai Kiadó, Budapest, Hungary.

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