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News Article | May 25, 2017
Site: www.prlog.org

Primus Hospital of Nigeria works with an aim to allow the Nigerians get the best treatments for their kidney ailments. Primus Hospital has been designed and constructed using the most advanced medical technology, available in the world. -- Given that patients are suggested to undergo a full body checkup to diagnose the diseases easily, Primus International Super Specialty Hospital has taken the initiative to provide superlative health care services to all its patients. That said, it isn't easy to tackle the kidney diseases and in the case of an emergency, great patient care is required. Working along the same lines as its counterparts, Primus Nigeria has a team of expert medical professional to handle even the most complex cases with ease.Nigeria, 23rd May, 2017. Conveniently located in the heart of Nigeria's capital, Abuja, Primus Super Specialty Hospital has all the advanced medical amenities needed for faster recovery, health, and well-being of a patient. Primus brings in a comprehensive range of treatment for the patients struck with chronic kidney diseases (CKDs), kidney failure, an acute kidney injury, or any other kidney related problems. Designed using the technological advanced medical equipment, Primus hospital showcases excellent infrastructure, 24 hour pharmacy to handle the most complex emergencies, and preventive health check for a more comfortable experience. Apart from covering almost all aspects of healthcare, Primus continues to contribute towards the upliftment of the country with the support of skilled medical professional on board. Not just that, the hospital also runs over a dozens of satellite clinics across the globe.Primus nephrology, dialysis and kidney transplant department is one of its kind and a home to several innovative treatments. The hospital uses minimally invasive techniques to diagnose and correct the urological and nephrological conditions. Nephrology is the branch of medicine dealing in kidney disorders. It's when the function of your kidneys is altered by other factors, is the time you need to contact a nephrologist. A nephrologist, or a kidney doctor further studies the condition of your kidneys and suggests possible treatment and care. At the end stage of renal disease, or kidney failure, a patient is either recommended haemodialysis or kidney transplant. At Primus, there are separate dialysis units for infected and non-infected patients – a rare thing to spot in Nigeria. The nephrologists here are highly qualified and extensively experienced that it helps them to offer patient-oriented management services to the clients.Primus Nigeria is spearheaded by the specialists in the department of nephrology. It offers cutting edge care in all areas of kidney disorder, namely:•Nephrology•Chronic Kidney Disease (CKD)•Hypertension•Pre and Post Renal Transplant•Diabetic Renal CareIn addition, it actively engages itself in organizing patients education programs related to nephrology.A brief about Primus Kidney Transplant Center, NigeriaThe patients with end-stage renal disease are recommended a kidney transplantation which is not a surgery to be performed by any doctor. It requires an expert's attention, and needs to be dealt with utmost precision. Nigeria has a limited number of healthcare facilities including Primus Multi Specialty Hospital. About its kidney transplant center, Primus has made its way to become a distinguished name in the field. Kidney transplants (organ procurement)can be genetically related or non-related. The kidney doctors at Primus use advanced techniques to treat such patients, and help them lead a better quality of life ahead. Adding to the relief of the patients, Primus also has associations with the organ donors so that it can save your life and help you live better.Details:-State of the Art Dialysis Center, PrimusApart from having paved its way to become the best kidney transplant hospital in Nigeria, Primus Super Specialty Hospital couldn't really have settled for less. It has got the modern and Advanced Kidney Dialysis (AKD) unit installed in its nephrology department. Just so you know, this department provides exceptional renal replacement therapy for both HIV+ and HCV infected and non-infected patients. On top of it, the patients are kept under constant observation through highly-sophisticated monitors throughout the dialysis process. As a major tertiary care center, its urology clinic is a unique resource for those with the diseases of urinary system including kidneys, bladder and prostate gland.Why choose Primus Hospital?Question is, why would anyone choose Primus over any other multi-specialty hospitals? The following points will reasonably answer the question.•Primus Nigeria has been built with an envision to bring Nigeria the highest standards of medical care•It periodically organizes various health related programs, clinical research and training•The hospital comprises a team of extremely proficient doctors who leave no stone unturned in handling even the most critical cases with composure•Support assistants are available on demand 24*7 for integrated emergency response servicesPrimus Nigeria is open for free consultation with the specialists.


This report studies Global Blood Dialysis Machine Market 2016, especially in North America, Europe, China, Japan, Southeast Asia and India, with production, revenue, consumption, import and export in these regions, from 2011 to 2015, and forecast to 2021. This report focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering Fresenius Medical Care Baxter  Nipro B. Braun Melsungen AG  Nikkiso  Allmed Medical Gambro Toray Bellco NxStage Medical Inc. Asahi—Kasei  JMS Co.Ltd. SWS Medical  Chongqing Duotai Medical Equipment China Chengdu Wesley Biotech  Chongqing Aokland Medical Equipment Research By types, the market can be split into Center-use Hemodialysis Machines Home-use Hemodialysis Machines Type III By Application, the market can be split into Dialysis Center Hospitals Home Hemodialysis Others By Regions, this report covers (we can add the regions/countries as you want) North America China Europe Southeast Asia Japan India Table of Contents Global Blood Dialysis Machine Market Professional Survey Report 2016 1 Industry Overview of Blood Dialysis Machine 1.1 Definition and Specifications of Blood Dialysis Machine 1.1.1 Definition of Blood Dialysis Machine 1.1.2 Specifications of Blood Dialysis Machine 1.2 Classification of Blood Dialysis Machine 1.2.1 Center-use Hemodialysis Machines 1.2.2 Home-use Hemodialysis Machines 1.2.3 Type III 1.3 Applications of Blood Dialysis Machine 1.3.1 Dialysis Center 1.3.2 Hospitals 1.3.3 Home Hemodialysis 1.3.4 Others 1.4 Market Segment by Regions 1.4.1 North America 1.4.2 China 1.4.3 Europe 1.4.4 Southeast Asia 1.4.5 Japan 1.4.6 India 8 Major Manufacturers Analysis of Blood Dialysis Machine 8.1 Fresenius Medical Care 8.1.1 Company Profile 8.1.2 Product Picture and Specifications 8.1.2.1 Type I 8.1.2.2 Type II 8.1.2.3 Type III 8.1.3 Fresenius Medical Care 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.1.4 Fresenius Medical Care 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.2 Baxter  8.2.1 Company Profile 8.2.2 Product Picture and Specifications 8.2.2.1 Type I 8.2.2.2 Type II 8.2.2.3 Type III 8.2.3 Baxter 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.2.4 Baxter 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.3 Nipro 8.3.1 Company Profile 8.3.2 Product Picture and Specifications 8.3.2.1 Type I 8.3.2.2 Type II 8.3.2.3 Type III 8.3.3 Nipro 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.3.4 Nipro 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.4 B. Braun Melsungen AG  8.4.1 Company Profile 8.4.2 Product Picture and Specifications 8.4.2.1 Type I 8.4.2.2 Type II 8.4.2.3 Type III 8.4.3 B. Braun Melsungen AG 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.4.4 B. Braun Melsungen AG 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.5 Nikkiso  8.5.1 Company Profile 8.5.2 Product Picture and Specifications 8.5.2.1 Type I 8.5.2.2 Type II 8.5.2.3 Type III 8.5.3 Nikkiso 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.5.4 Nikkiso 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.6 Allmed Medical 8.6.1 Company Profile 8.6.2 Product Picture and Specifications 8.6.2.1 Type I 8.6.2.2 Type II 8.6.2.3 Type III 8.6.3 Allmed Medical 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.6.4 Allmed Medical 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.7 Gambro 8.7.1 Company Profile 8.7.2 Product Picture and Specifications 8.7.2.1 Type I 8.7.2.2 Type II 8.7.2.3 Type III 8.7.3 Gambro 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.7.4 Gambro 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.8 Toray 8.8.1 Company Profile 8.8.2 Product Picture and Specifications 8.8.2.1 Type I 8.8.2.2 Type II 8.8.2.3 Type III 8.8.3 Toray 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.8.4 Toray 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.9 Bellco 8.9.1 Company Profile 8.9.2 Product Picture and Specifications 8.9.2.1 Type I 8.9.2.2 Type II 8.9.2.3 Type III 8.9.3 Bellco 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.9.4 Bellco 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.10 NxStage Medical Inc. 8.10.1 Company Profile 8.10.2 Product Picture and Specifications 8.10.2.1 Type I 8.10.2.2 Type II 8.10.2.3 Type III 8.10.3 NxStage Medical Inc. 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.10.4 NxStage Medical Inc. 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.11 Asahi—Kasei  8.11.1 Company Profile 8.11.2 Product Picture and Specifications 8.11.2.1 Type I 8.11.2.2 Type II 8.11.2.3 Type III 8.11.3 Asahi—Kasei 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.11.4 Asahi—Kasei 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.12 JMS Co.Ltd. 8.12.1 Company Profile 8.12.2 Product Picture and Specifications 8.12.2.1 Type I 8.12.2.2 Type II 8.12.2.3 Type III 8.12.3 JMS Co.Ltd. 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.12.4 JMS Co.Ltd. 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.13 SWS Medical  8.13.1 Company Profile 8.13.2 Product Picture and Specifications 8.13.2.1 Type I 8.13.2.2 Type II 8.13.2.3 Type III 8.13.3 SWS Medical 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.13.4 SWS Medical 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.14 Chongqing Duotai Medical Equipment 8.14.1 Company Profile 8.14.2 Product Picture and Specifications 8.14.2.1 Type I 8.14.2.2 Type II 8.14.2.3 Type III 8.14.3 Chongqing Duotai Medical Equipment 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.14.4 Chongqing Duotai Medical Equipment 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.15 China Chengdu Wesley Biotech  8.15.1 Company Profile 8.15.2 Product Picture and Specifications 8.15.2.1 Type I 8.15.2.2 Type II 8.15.2.3 Type III 8.15.3 China Chengdu Wesley Biotech 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.15.4 China Chengdu Wesley Biotech 2015 Blood Dialysis Machine Business Region Distribution Analysis 8.16 Chongqing Aokland Medical Equipment Research 8.16.1 Company Profile 8.16.2 Product Picture and Specifications 8.16.2.1 Type I 8.16.2.2 Type II 8.16.2.3 Type III 8.16.3 Chongqing Aokland Medical Equipment Research 2015 Blood Dialysis Machine Sales, Ex-factory Price, Revenue, Gross Margin Analysis 8.16.4 Chongqing Aokland Medical Equipment Research 2015 Blood Dialysis Machine Business Region Distribution Analysis Global QYResearch (http://globalqyresearch.com/ ) is the one spot destination for all your research needs. Global QYResearch holds the repository of quality research reports from numerous publishers across the globe. Our inventory of research reports caters to various industry verticals including Healthcare, Information and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc. With the complete information about the publishers and the industries they cater to for developing market research reports, we help our clients in making purchase decision by understanding their requirements and suggesting best possible collection matching their needs.


South Nassau Communities Hospital Names, Dedicates Medical Library in Honor of Former Medical Staff President Dr. Singh joined South Nassau in 1977, and from that year onward he was a dependable, wise source of leadership, demonstrating a zeal for medical innovation centered on patient-centered care. Oceanside, NY, February 17, 2017 --( So it was appropriate that on Friday, February 10 at South Nassau Communities Hospital in Oceanside, NY, family, friends, physicians, hospital staff and board members joined together to celebrate the naming and dedication of the hospital's medical library in honor of Harbhajan Singh, MD. While patients remember Dr. Singh, a pulmonologist, for his compassionate, expert medical care, his peers and staff who worked side-by-side with him at South Nassau for more than half of his 52-year career in medicine, attest that they were inspired by his steadfast pursuit to learn more and to understand more and to put that knowledge to work to raise the quality and standard of medical care that he provided his patients. "When we look at the history and growth of South Nassau Communities Hospital, they are indelibly marked with Dr. Singh's passion for patient-centered medicine and devotion to the hospital's mission and vision," said Richard J. Murphy, President & CEO. "On behalf of South Nassau physicians, staff and board members past, present and future, I salute Dr. Singh for his exemplary career in medicine. It is our honor that we now call this the Harbhajan Singh, MD, Medical Library. " Dr. Singh joined South Nassau in 1977, and from that year onward he was a dependable, wise source of leadership, demonstrating a zeal for medical innovation centered on patient-centered care. During his more than 30 years at South Nassau, Dr. Singh held staff appointments as President of the Medical Staff, Chief of Pulmonary Medicine, Director of the Respiratory Therapy Department, and Chairman of the Respiratory Therapy Committee, among many others. Through those appointments Dr. Singh mentored numerous staff physicians and served as a catalyst behind South Nassau's growth and expansion, which continues today. During his tenure as medical staff president, South Nassau completed an expansion of its Ambulatory Surgery Unit (ASU) to include 10 private patient suites and an enlarged holding area; established an Outpatient Dialysis Center with 18 patient suites; introduced advancements in medical technology including the multislice CT scanner; a 3-D diagnostic imaging system to locate and cure rapid heartbeats; and MicroEndoscopic Discectomy, a minimally invasive surgical procedure used to correct disabling spinal disc problems. A native of India, Dr. Singh began his distinguished career in medicine upon graduating from Amristar Medical College in 1963, (working as an internist in New Delhi). In 1968, he migrated to the United States, with his wife Naginder and they settled in Rockville Centre. While she raised their sons, Charnjit (C.J.) and Sarbjit, Dr. Singh completed residency training in internal medicine and a fellowship in pulmonary medicine, soon thereafter he opened a medical office on Merrick Rd. and then Hempstead Ave. in Lynbrook, providing specialized care in pulmonary and internal medicine. He was board certified in Internal Medicine, Pulmonary Medicine, Critical Care Medicine and Sleep Medicine. Inspired by his father's love for medicine and the compassionate care that he provided his patients, son C.J. chose a career in medicine as well. He has been an attending physician at South Nassau specializing in gastroenterology for almost 2 decades. Sarbjit is a tenured professor at Farmingdale State College in Sports Business. Naginder has worked in an array of volunteer capacities for South Nassau. "The naming and dedication of the medical library in Dr. Singh's honor will serve as a constant reminder of his commitment to lifelong learning and of his leadership to build on the hospital's tradition of excellence in health care," said Adhi Sharma, MD, chief medical officer. The Harbhajan Singh, MD Medical Library offers a collection of books, journals (both print and online), and access to clinical databases. The library's mission is to meet the ongoing information needs of physicians and other clinical staff in support of patient care, teaching, learning, and research. Oceanside, NY, February 17, 2017 --( PR.com )-- A library is a reflection of the passion for lifelong learning, the search for answers and when either or both are attained, the reward of knowledge, understanding and discernment that is to the benefit of the individual as well as those served by the individual.So it was appropriate that on Friday, February 10 at South Nassau Communities Hospital in Oceanside, NY, family, friends, physicians, hospital staff and board members joined together to celebrate the naming and dedication of the hospital's medical library in honor of Harbhajan Singh, MD.While patients remember Dr. Singh, a pulmonologist, for his compassionate, expert medical care, his peers and staff who worked side-by-side with him at South Nassau for more than half of his 52-year career in medicine, attest that they were inspired by his steadfast pursuit to learn more and to understand more and to put that knowledge to work to raise the quality and standard of medical care that he provided his patients."When we look at the history and growth of South Nassau Communities Hospital, they are indelibly marked with Dr. Singh's passion for patient-centered medicine and devotion to the hospital's mission and vision," said Richard J. Murphy, President & CEO. "On behalf of South Nassau physicians, staff and board members past, present and future, I salute Dr. Singh for his exemplary career in medicine. It is our honor that we now call this the Harbhajan Singh, MD, Medical Library. "Dr. Singh joined South Nassau in 1977, and from that year onward he was a dependable, wise source of leadership, demonstrating a zeal for medical innovation centered on patient-centered care. During his more than 30 years at South Nassau, Dr. Singh held staff appointments as President of the Medical Staff, Chief of Pulmonary Medicine, Director of the Respiratory Therapy Department, and Chairman of the Respiratory Therapy Committee, among many others. Through those appointments Dr. Singh mentored numerous staff physicians and served as a catalyst behind South Nassau's growth and expansion, which continues today.During his tenure as medical staff president, South Nassau completed an expansion of its Ambulatory Surgery Unit (ASU) to include 10 private patient suites and an enlarged holding area; established an Outpatient Dialysis Center with 18 patient suites; introduced advancements in medical technology including the multislice CT scanner; a 3-D diagnostic imaging system to locate and cure rapid heartbeats; and MicroEndoscopic Discectomy, a minimally invasive surgical procedure used to correct disabling spinal disc problems.A native of India, Dr. Singh began his distinguished career in medicine upon graduating from Amristar Medical College in 1963, (working as an internist in New Delhi). In 1968, he migrated to the United States, with his wife Naginder and they settled in Rockville Centre. While she raised their sons, Charnjit (C.J.) and Sarbjit, Dr. Singh completed residency training in internal medicine and a fellowship in pulmonary medicine, soon thereafter he opened a medical office on Merrick Rd. and then Hempstead Ave. in Lynbrook, providing specialized care in pulmonary and internal medicine. He was board certified in Internal Medicine, Pulmonary Medicine, Critical Care Medicine and Sleep Medicine.Inspired by his father's love for medicine and the compassionate care that he provided his patients, son C.J. chose a career in medicine as well. He has been an attending physician at South Nassau specializing in gastroenterology for almost 2 decades. Sarbjit is a tenured professor at Farmingdale State College in Sports Business. Naginder has worked in an array of volunteer capacities for South Nassau."The naming and dedication of the medical library in Dr. Singh's honor will serve as a constant reminder of his commitment to lifelong learning and of his leadership to build on the hospital's tradition of excellence in health care," said Adhi Sharma, MD, chief medical officer.The Harbhajan Singh, MD Medical Library offers a collection of books, journals (both print and online), and access to clinical databases. The library's mission is to meet the ongoing information needs of physicians and other clinical staff in support of patient care, teaching, learning, and research. Click here to view the list of recent Press Releases from South Nassau Communities Hospital


Brandenburg V.M.,RWTH Aachen | Kramann R.,RWTH Aachen | Koos R.,RWTH Aachen | Kruger T.,RWTH Aachen | And 6 more authors.
BMC Nephrology | Year: 2013

Background: Sclerostin is a Wnt pathway antagonist regulating osteoblast activity and bone turnover. Here, we assessed the potential association of sclerostin with the development of coronary artery (CAC) and aortic valve calcifications (AVC) in haemodialysis (HD) patients. Methods. We conducted a cross-sectional multi-slice computed tomography (MS-CT) scanning study in 67 chronic HD patients (59.4 ± 14.8 yrs) for measurement of CAC and AVC. We tested established biomarkers as well as serum sclerostin (ELISA) regarding their association to the presence of calcification. Fifty-four adults without relevant renal disease served as controls for serum sclerostin levels. Additionally, sclerostin expression in explanted aortic valves from 15 dialysis patients was analysed ex vivo by immunohistochemistry and mRNA quantification (Qt-RT-PCR). Results: CAC (Agatston score > 100) and any AVC were present in 65% and in 40% of the MS-CT patient group, respectively. Serum sclerostin levels (1.53 ± 0.81 vs 0.76 ± 0.31 ng/mL, p < 0.001) were significantly elevated in HD compared to controls and more so in HD patients with AVC versus those without AVC (1.78 ± 0.84 vs 1.35 ± 0.73 ng/mL, p = 0.02). Multivariable regression analysis for AVC revealed significant associations with higher serum sclerostin. Ex vivo analysis of uraemic calcified aortic valves (n = 10) revealed a strong sclerostin expression very close to calcified regions (no sclerostin staining in non-calcified valves). Correspondingly, we observed a highly significant upregulation of sclerostin mRNA in calcified valves compared to non-calcified control valves. Conclusion: We found a strong association of sclerostin with calcifying aortic heart valve disease in haemodialysis patients. Sclerostin is locally produced in aortic valve tissue adjacent to areas of calcification. © 2013 Brandenburg et al.; licensee BioMed Central Ltd.


Krieter D.H.,University of Würzburg | Canaud B.,Montpellier University | Lemke H.-D.,Membrana GmbH | Rodriguez A.,Montpellier University | And 4 more authors.
Artificial Organs | Year: 2013

The estrogenic endocrine-disrupting substance bisphenol A (BPA) is extensively used as a starting material for a variety of consumer plastic products including dialyzer materials. The present study was performed to explore plasma BPA levels in patients with impaired renal function and to investigate if dialyzers differing in elutable BPA influence plasma levels in patients on maintenance hemodialysis. In vitro BPA was eluted from high-flux polyethersulfone (PUREMA H, referred as PUR-H), high-flux polysulfone (referred as HF-PSu), and low-flux polysulfone (referred as LF-PSu) dialyzers by recirculation with water for 180min. In a cross-sectional clinical study, plasma BPA levels of outpatients with different stages of chronic kidney disease (CKD) from four different centers were determined. Furthermore, in a prospective, randomized, and crossover setting, 18 maintenance dialysis patients were subjected successively to 4 weeks of thrice-weekly hemodialysis with each LF-PSu, HF-PSu, and PUR-H. In addition, the fractions of protein-bound and free BPA were determined in a subset of dialysis patients. The mass of BPA eluted from the blood compartments in vitro under aqueous conditions varied for the three dialyzers being very low for PUR-H (6.2±2.5ng; P<0.001), intermediate for HF-PSu (48.1±7.7ng), and highest for LF-PSu (140.8±38.7ng; P<0.01). In 152 prevalent patients with CKD enrolled in the cross-sectional trial, plasma BPA started to rise after stage 3. Maintenance hemodialysis patients had more than six times higher BPA concentrations than patients with CKD stage 5 not yet on dialysis (10.0±6.6 vs. 1.6±1.8ng/mL; P<0.001). The BPA concentrations highly and inversely correlated with renal function. In the randomized controlled study, the plasma BPA concentrations were highly elevated compared with healthy controls (range 9.1±4.5-12.0±6.0ng/mL vs. ≤0.2±0.1ng/mL; P<0.001), but no change of the plasma levels was observed during hemodialysis with any of the three dialyzers in the course of a single treatment and over a period of 4 weeks. The protein-bound fraction of plasma BPA in the dialysis patients was 74±5%. Renal function and, most likely, the total quantity of ingested BPA are essential parameters affecting plasma BPA concentrations. Dialyzers are one additional source of BPA, but differences in the elutable BPA content are not associated with a significant effect on BPA plasma levels in Western European maintenance dialysis patients. Due to high protein binding, the removal of BPA by hemodialysis is limited.© 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.


Niepolski L.,Dialysis Center | Grzegorzewska A.E.,Poznan University of Medical Sciences
Advances in Medical Sciences | Year: 2016

Dyslipidemia is one of the most potent risk factors for the development of atherosclerosis. The high atherosclerotic risk in dyslipidemic patients is associated with endothelial dysfunction. During the last two decades, novel bioactive peptides have emerged as potential biomarkers of endothelial dysfunction and dyslipidemia-salusins and adropin. Salusin-alpha is likely to prevent atherosclerosis, while salusin-beta may act as a potential proatherogenic factor. Adropin was recently identified as important for energy homeostasis and lipid metabolism. Adropin is closely related to the inhibition of atherosclerosis by up-regulation of the endothelial nitric oxide synthase expression through the vascular endothelial growth factor receptor-2. These peptides represent a novel target to limit diseases characterized by endothelial dysfunction and may form the basis for the development of new therapeutic agents for treating metabolic disorders associated with atherosclerosis. © 2016 Medical University of Bialystok. Published by Elsevier Sp. z o.o. All rights reserved.


Artunc F.,University of Tübingen | Mueller C.,University of Basel | Breidthardt T.,University of Basel | Twerenbold R.,University of Basel | And 6 more authors.
PLoS ONE | Year: 2012

Background: In hemodialysis patients, elevated plasma troponin concentrations are a common finding that has even increased with the advent of newly developed sensitive assays. However, the interpretation and relevance of this is still under debate. Methods: In this cross-sectional study, we analyzed plasma concentrations of sensitive troponin I (TnI) and troponin T (TnT) in stable ambulatory hemodialysis patients (n = 239) and investigated their associations with clinical factors and mortality. Results: In all of the enrolled patients, plasma TnI or TnT was detectable at a median concentration of 14 pg/ml (interquartile range: 7-29) using the Siemens TnI ultra assay and 49 pg/ml (31-74) using the Roche Elecsys high sensitive TnT assay. Markedly more patients exceeded the 99th percentile for TnT than for TnI (95% vs. 14%, p<0.0001). In a multivariate linear regression model, TnT was independently associated with age, gender, systolic dysfunction, time on dialysis, residual diuresis and systolic blood pressure, whereas TnI was independently associated with age, systolic dysfunction, pulse pressure, time on dialysis and duration of a HD session. During a follow-up period of nearly two years, TnT concentration above 38 pg/mL was associated with a 5-fold risk of death, whereas elevation of TnI had a gradual association to mortality. Conclusion: In hemodialysis patients, elevations of plasma troponin concentrations are explained by cardiac function and dialysis-related parameters, which contribute to cardiac strain. Both are highly predictive of increased risk of death. © 2012 Artunc et al.


Patients undergoing renal replacement therapy have a higher risk of developing tuberculosis (TBC) in comparison with normal renal function population. The anergy to the tuberculin skin test, the lack of characteristic clinical symptoms of TBC and typical radiographic signs, and high prevalence of extrapulmonary TBC make the diagnosis in dialysis patients difficult and often delay the treatment. In contrast to the active TBC, latent TBC infection (LTBI) is asymptomatic and is not a direct epidemiological problem. However, in patients with end-stage renal disease prepared for renal transplantation,it is an obstacle to qualifying for immunosuppressive therapy. Treatment of LTBI patients with antimycobacterial medication decreases about 90% risk of developing active TB. Therefore, the possibility of a fast and easy identification of LTBI in this group of patients is extremely important. Test QuantiFERON-TB Gold In-Tube (QFT-G) is a new, simple and rapid diagnostic tool in LTBI and active tuberculosis infection (in conjunction with previously used clinical and microbiological methods). This test has been approved and is used in many European countries and in the USA. In a 65-year old patient, treated for 5 years with continuous ambulatory peritoneal dialysis, positive QFT-G results were shownin the course of diagnosis before reporting to the transplant program. After conducting an extensive diagnosis for tuberculosis infection (epidemiological interview, clinical examination, imaging studies, cultures by MB/BacT and the conventional method, consultations with a pulmonologist), latent form of tuberculosis was diagnosed with unspecified location. Due to the positive QFT-G and the need for future immunosuppressive treatment after kidney transplantation, a three-month prophylactic treatment with Rifamazyd 450 mg per day was included. After treatment, the patient entered the waiting list for a kidney transplant. Test QFT-G, in conjunction with other conventional methods is a good and rapid diagnostic tool in the identification of LTBI.


Vlachopanos G.,Dialysis Center
BANTAO Journal | Year: 2012

Drug Reaction with Eosinophilia and Systematic Symptoms (DRESS) syndrome is a serious, idiosyncratic reaction to pharmaceutical substances which is characterized by a considerable mortality rate. Special attention should be paid to the fact that it presents with a long latency period, usually 2 to 6 weeks after culprit drug exposure. We report a case of a 79-year-old diabetic female on chronic hemodialysis who was admitted with acute febrile pancreatitis and soon afterwards developed eosinophilia and diffuse maculopapular rash. She was diagnosed promptly with DRESS syndrome induced by phenytoin, which was started approximately one month before. Substitution of phenytoin with levetiracetam and a brief course of oral corticosteroids led to a full recovery.


Afsar B.,Konya Numune State Hospital | Elsurer R.,Selcuk University | Kirkpantur A.,Dialysis Center | Kanbay M.,Koç University
Journal of Clinical Hypertension | Year: 2015

Use of ambulatory blood pressure (BP) monitoring (ABPM) allows for identification of dipping, nondipping, extreme dipping, and reverse dipping of BP. Using office BP and ABPM, hypertension subtypes can be identified: sustained normotension (SNT), white-coat hypertension, masked hypertension, and sustained hypertension. The comparison of hemodynamic parameters and salt intake has not been investigated among these patient groups. Office BP, ABPM, augmentation index (AIx), pulse wave velocity (PWV), cardiac output (CO), and total peripheral resistance (TPR) were automatically measured. Estimation of salt intake was assessed by 24-hour urinary sodium excretion. Urinary sodium excretion was not different among groups. AIx, PWV, CO, and TPR were lowest in patients with SNT. CO was lowest while AIx adjusted for a heart rate of 75 beats per minute, PWV, and TPR were highest in the extreme dipper group. No relationship was detected between hypertension subtypes and urinary sodium excretion. ©2015 Wiley Periodicals, Inc.

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