Periannan R.,Diagnostic Services and Research Center |
Balakrishnan S.,Diagnostic Services and Research Center |
Khashim Z.,Diagnostic Services and Research Center |
Kanagasabai T.,Diagnostic Services and Research Center |
And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012
Alzheimer's disease AD, is the most common form of dementia caused by abnormal fragmentation of amyloid precursor protein by presenilins of γ-secretase protease complex. There are 2 types of presenilins called 1 and 2 and each exists in 2 isoforms. The aim of this study was to get the presenilin sequences from the protein data base and to study functional motifs using motif scan tool and to interpret their functions by computational methods. Motif scan tool identified motifs in presenilin 1 viz., Asn_Glycosylation, Camp_Phospho_Site, Ck2_Phospho_Site, Myristyl, Pkc_Phospho_Site, Arteri_GP4, Coq4, NADHDh, Presenilin, c4dic_mal_tran, Oxidored_q5_N. Motifs identified in presenilin 2 were Asn_Glycosylation, Ck2_Phospho_Site, Myristyl, Pkc_Phospho_Site, Arteri_GP4, Pr esenilin. Clustal W results showed both presenilin 1 and 2 have 65% identical sequences.