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Sabadell, Spain

Pons G.,University of Girona | Marti J.,University of Girona | Marti R.,University of Girona | Ganau S.,Center Diagnostic | Noble J.A.,University of Oxford
Ultrasonic Imaging | Year: 2015

Breast ultrasound (BUS) imaging has become a crucial modality, especially for providing a complementary view when other modalities (i.e., mammography) are not conclusive in the task of assessing lesions. The specificity in cancer detection using BUS imaging is low. These false-positive findings often lead to an increase of unnecessary biopsies. In addition, increasing sensitivity is also challenging given that the presence of artifacts in the B-mode ultrasound (US) images can interfere with lesion detection. To deal with these problems and improve diagnosis accuracy, ultrasound elastography was introduced. This paper validates a novel lesion segmentation framework that takes intensity (B-mode) and strain information into account using a Markov Random Field (MRF) and a Maximum a Posteriori (MAP) approach, by applying it to clinical data. A total of 33 images from two different hospitals are used, composed of 14 cancerous and 19 benign lesions. Results show that combining both the B-mode and strain data in a unique framework improves segmentation results for cancerous lesions (Dice Similarity Coefficient of 0.49 using B-mode, while including strain data reaches 0.70), which are difficult images where the lesions appear with blurred and not well-defined boundaries. © SAGE Publications.


Rolo D.,University of Barcelona | Rolo D.,CIBER ISCIII | Fenoll A.,National Center for Microbiology | Fontanals D.,Center Diagnostic | And 8 more authors.
Journal of Clinical Microbiology | Year: 2013

In this study, we analyzed the clinical and molecular epidemiology of invasive serotype 5 (Ser5) pneumococcal isolates in four teaching hospitals in the Barcelona, Spain, area (from 1997 to 2011). Among 5,093 invasive pneumococcal isolates collected, 134 (2.6%) Ser5 isolates were detected. Although the overall incidence of Ser5-related invasive pneumococcal disease (IPD) was low (0.25 cases/100,000 inhabitants), three incidence peaks were detected: 0.63/100,000 in 1999, 1.15/100,000 in 2005, and 0.37/100,000 in 2009. The rates of Ser5 IPD were higher among young adults (18 to 64 years old) and older adults (>64 years old) in the first two peaks, whereas they were higher among children in 2009. The majority (88.8%) of the patients presented with pneumonia. Comorbid conditions were present in young adults (47.6%) and older adults (78.7%), the most common comorbid conditions being chronic obstructive pulmonary disease (20.6% and 38.3%, respectively) and cardiovascular diseases (11.1% and 38.3%, respectively). The mortality rates were higher among older adults (8.5%). All Ser5 pneumococci tested were fully susceptible to penicillin, cefotaxime, erythromycin, and ciprofloxacin. The resistance rates were 48.5% for co-trimoxazole, 6.7% for chloramphenicol, and 6% for tetracycline. Two major related sequence types (STs), ST1223 (n-65) and ST289 (n-61), were detected. The Colombia5-ST289 clone was responsible for all the cases in the Ser5 outbreak in 1999, whereas the ST1223 clone accounted for 73.8% and 61.5% of the isolates in 2005 and 2009, respectively. Ser5 pneumococci are a frequent cause of IPD outbreaks in the community and involve children and adults with or without comorbidities. The implementation of the new pneumococcal conjugated vaccines (PCV10 and PCV13) might prevent such outbreaks. Copyright © 2013, American Society for Microbiology. All Rights Reserved.


Elawady M.,CNRS Hubert Curien Laboratory | Sadek I.,Image and Pervasive Access Laboratory | Shabayek A.E.R.,Suez Canal University | Pons G.,University of Girona | Ganau S.,Center Diagnostic
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Breast cancer is one of the leading causes of cancer death among women worldwide. The proposed approach comprises three steps as follows. Firstly, the image is preprocessed to remove speckle noise while preserving important features of the image. Three methods are investigated, i.e., Frost Filter, Detail Preserving Anisotropic Diffusion, and Probabilistic Patch-Based Filter. Secondly, Normalized Cut or Quick Shift is used to provide an initial segmentation map for breast lesions. Thirdly, a postprocessing step is proposed to select the correct region from a set of candidate regions. This approach is implemented on a dataset containing 20 B-mode ultrasound images, acquired from UDIAT Diagnostic Center of Sabadell, Spain. The overall system performance is determined against the ground truth images. The best system performance is achieved through the following combinations: Frost Filter with Quick Shift, Detail Preserving Anisotropic Diffusion with Normalized Cut and Probabilistic Patch-Based with Normalized Cut. © Springer International Publishing Switzerland 2016.


Pierard-Franchimont C.,Unilab Lg | Peters S.,University of Liege | Hermanns J.-F.,Center Diagnostic | Lesuise M.,CHR Citadelle | And 4 more authors.
Revue Medicale de Liege | Year: 2014

Striae distensae represent a common skin condition, corresponding to a physiological event particularly developed during adolescence, pregnancy and gain in body weight. In addition, these lesions are induced by the Cushing syndrome or an intense corticotherapy. The viscoelastic properties of the skin are altered and vary according to the severity of striae distensae. Otherwise, the colours of striae distensae vary with time in response to the mechanobiology of blood vessels and melanocytes.


Saus E.,CIBER ISCIII | Brunet A.,CIBER ISCIII | Armengol L.,CIBER ISCIII | Alonso P.,CIBER ISCIII | And 19 more authors.
Journal of Psychiatric Research | Year: 2010

Background: Copy number variations (CNV) have become an important source of human genome variability noteworthy to consider when studying genetic susceptibility to complex diseases. As recent studies have found evidences for the potential involvement of CNVs in psychiatric disorders, we have studied the dosage effect of structural genome variants as a possible susceptibility factor for different psychiatric disorders in a candidate gene approach. Methods: After selection of 68 psychiatric disorders' candidate genes overlapping with CNVs, MLPA assays were designed to determine changes in copy number of these genes. The studied sample consisted of 724 patients with psychiatric disorders (accounting for anxiety disorders, mood disorders, eating disorders and schizophrenia) and 341 control individuals. Results: CNVs were detected in 30 out of the 68 genes screened, indicating that a considerable proportion of neuronal pathways genes contain CNVs. When testing the overall burden of rare structural genomic variants in the different psychiatric disorders compared to control individuals, there was no statistically significant difference in the total amount of gains and losses. However, 14 out of the 30 changes were only found in psychiatric disorder patients but not in control individuals. These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. Conclusions: Although we have not been able to found a clear association between the studied CNVs and psychiatric disorders, the rare variants found only within the patients could account for a step further towards understanding the pathophysiology of psychiatric disorders. © 2010 Elsevier Ltd.

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