Time filter

Source Type

Shimabukuro M.,Tokushima University | Hasegawa Y.,Tokushima University | Higa M.,Diabetes and Lifestyle Related Disease Center | Amano R.,Tokushima University | And 4 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2015

Aim: The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region- and sex-specific differences in the degree of atherosclerosis. Methods: Non-diabetic subjects included Okinawa (n=1674) and Nagano (n=1392) residents aged 30– 75 years who underwent carotid ultrasonography for the measurement of maximum intimamedia thickness (max IMT). Results: Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women. Conclusions: This is the first report to show region- and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region- and sex-specific differences in carotid atherosclerosis burden may be required. © 2015, Japan Atherosclerosis Society. All rights reserved. Source

Shimabukuro M.,Tokushima University | Kozuka C.,University of Ryukyus | Taira S.-I.,University of Ryukyus | Yabiku K.,University of Ryukyus | And 11 more authors.
Journal of Medical Investigation | Year: 2013

The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity. Source

Shimabukuro M.,University of Ryukyus | Shimabukuro M.,Diabetes and Lifestyle Related Disease Center | Higa M.,Diabetes and Lifestyle Related Disease Center | Tanaka H.,Tanaka Clinic | And 3 more authors.
Diabetic Medicine | Year: 2011

Aims Effects of pitavastatin and atorvastatin on the lipid profile and lipoprotein subclasses were compared in patients with Type2 diabetes with dyslipidaemia. Methods Patients with Type2 diabetes with hypercholesterolaemia and/or hypertriglyceridaemia were randomized to receive pitavastatin 2mg (n=16) or atorvastatin 10mg (n=15) for 6months, and blood lipid and lipoprotein profiles and cholesterol and triglyceride contents of 20 lipoprotein subclasses, determined by high-performance liquid chromatography, were compared. Results At baseline, cholesterol in VLDL and LDL subclasses were increased equally in two groups of patients with diabetes as compared with normolipidaemic control subjects. As compared with baseline, serum levels of total cholesterol, LDL cholesterol, non-HDL cholesterol, LDL cholesterol:HDL cholesterol ratio and apolipoproteinB were decreased after 1, 3 and 6months of treatment with atorvastatin and pitavastatin. Serum triglyceride levels were decreased after 1, 3 and 6months of atorvastatin, but only at 3months of pitavastatin. Serum HDL cholesterol was increased after 1, 3 and 6months of pitavastatin, whereas HDL cholesterol was even decreased after 6months of atorvastatin. Cholesterol levels of most VLDL and LDL subclasses were decreased equally in both groups. However, only pitavastatin increased cholesterol of medium HDL subclass. Serum triglyceride and triglyceride contents in VLDL and LDL subclasses were decreased only by atorvastatin. Conclusions The impact on lipoprotein subclass profiles was different between pitavastatin and atorvastatin. It may be beneficial to determine lipoprotein subclass profile and select the appropriate statin for each profile in patients with diabetes with an additional cardiovascular risk such as low HDL cholesterol or hypertriglyceridaemia. © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. Source

Shimabukuro M.,Tokushima University | Shimabukuro M.,University of Ryukyus | Shimabukuro M.,Diabetes and Lifestyle Related Disease Center | Higa M.,University of Ryukyus | And 9 more authors.
British Journal of Nutrition | Year: 2014

Brown rice (BR) and white rice (WR) produce different glycaemic responses and their consumption may affect the dietary management of obesity. In the present study, the effects of BR and WR on abdominal fat distribution, metabolic parameters and endothelial function were evaluated in subjects with the metabolic syndrome in a randomised cross-over fashion. In study 1, acute postprandial metabolic parameters and flow-and nitroglycerine-mediated dilation (FMD and NMD) of the brachial artery were determined in male volunteers with or without the metabolic syndrome after ingestion of either BR or WR. The increases in glucose and insulin AUC were lower after ingestion of BR than after ingestion of WR (P=0·041 and P=0·045, respectively). FMD values were decreased 60min after ingestion of WR (P=0·037 v. baseline), but the decrease was protected after ingestion of BR. In study 2, a separate cohort of male volunteers (n 27) with the metabolic syndrome was randomised into two groups with different BR and WR consumption patterns. The values of weight-based parameters were decreased after consumption of BR for 8 weeks, but returned to baseline values after a WR consumption period. Insulin resistance and total cholesterol and LDL-cholesterol levels were reduced after consumption of BR. In conclusion, consumption of BR may be beneficial, partly owing to the lowering of glycaemic response, and may protect postprandial endothelial function in subjects with the metabolic syndrome. Long-term beneficial effects of BR on metabolic parameters and endothelial function were also observed. Copyright © The Authors 2013. Source

Discover hidden collaborations