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Miami, FL, United States

Trademark
Dharma Biomedical LLC | Date: 2011-02-28

Cosmeceuticals, namely, biologically active plant and herb extracts for use in the manufacture of cosmetics. Dietary supplements and nutraceuticals for use as dietary supplements, all comprising plant, herb and botanical extracts for use as additives to food to promote nutrient absorption, glucose metabolism, blood lipid metabolism, mitochondrial biogenesis, primary energy production, increased catabolism and reduced lipid production, sold in powder, liquid, liposomal, nanoencapsulation, and nanoemulsion forms; cosmeceuticals, namely, medicated skin care preparations; cosmeceuticals, namely, nutritional supplements in lotion form sold as a component of nutritional skin care products.


Trademark
Dharma Biomedical LLC | Date: 2011-02-28

Dietary supplements and nutraceuticals for use as dietary supplements, all comprising plant, herb and botanical extracts for use as additives to food to promote nutrient absorption, immune competence, immune regulation, immune support, immune recognition, immune response signaling, effective immune-mediated inflammatory responsiveness, natural killer cell activation, cell protection, immunemediated healthy cell function and antioxidant protection, sold in powder, liquid, liposomal, nanoencapsulation, and nanoemulsion forms.


Patent
Dharma Biomedical Llc and Flavex Naturextrakte Gmbh | Date: 2013-01-11

The subject invention pertains to supercritical carbon dioxide extracts of


Ramachandran C.,Dharma Biomedical LLC | Nair S.M.,Dharma Biomedical LLC | Quirrin K.-W.,Flavex Naturextrakte GmbH | Melnick S.J.,Dharma Biomedical LLC
Journal of Evidence-Based Complementary and Alternative Medicine | Year: 2013

The hypolipidemic effects of the poorly soluble ayurvedic resin guggul, especially the molecular targets and mechanism, have not been well investigated to date. In the present study, we have formulated a liquid product, GU-MCT810, composed of a proprietary Commiphora mukul gum resin extract and medium-chain triglyceride and investigated its hypolipidemic effects in vitro. Treatment of HepG2 cells significantly reduced low-density lipoprotein cholesterol and increased the high-density lipoprotein/low-density lipoprotein ratio. GU-MCT810 showed direct inhibition of HMG-CoA reductase activity in a dose-dependent manner and compared very well with the inhibitory effect of statins like Pravastatin and Mevastatin. The adipocyte differentiation was also inhibited by GU-MCT810 treatment. GU-MCT810 increased the AMPKα phosphorylation and AMPK kinase activity and inhibited the phosphorylated form of mTOR expression, indicating the molecular targets affected by the nutraceutical compound. The preparation also highly upregulated the expression of LXR and PPARα genes and moderately upregulated BABP and SHP genes. © The Author(s) 2013. Source


Ramachandran C.,Miami Childrens Hospital | Ramachandran C.,Dharma Biomedical LLC | Lollett I.V.,Dharma Biomedical LLC | Escalon E.,Miami Childrens Hospital | And 3 more authors.
Journal of Evidence-Based Complementary and Alternative Medicine | Year: 2015

Mango ginger (Curcuma amada Roxb.) is among the less-investigated species of Curcuma for anticancer properties. We have investigated the anticancer potential and the mechanism of action of a supercritical CO2 extract of mango ginger (CA) in the U-87MG human glioblastoma cell line. CA demonstrated higher cytotoxicity than temozolomide, etoposide, curcumin, and turmeric force with IC50, IC75, and IC90 values of 4.92 μg/mL, 12.87 μg/mL, and 21.30 μg/mL, respectively. Inhibitory concentration values of CA for normal embryonic mouse hypothalamus cell line (mHypoE-N1) is significantly higher than glioblastoma cell line, indicating the specificity of CA against brain tumor cells. CompuSyn analysis indicates that CA acts synergistically with temozolomide and etoposide for the cytotoxicity with combination index values of <1. CA treatment also induces apoptosis in glioblastoma cells in a dose-dependent manner and downregulates genes associated with apoptosis, cell proliferation, telomerase activity, oncogenesis, and drug resistance in glioblastoma cells. © The Author(s) 2014. Source

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