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Kumar R.,Dhanalakshmi Srinivasan Medical College and Hospital
Indian journal of public health | Year: 2015

Monitoring of risk factors for non-communicable diseases (NCDs) over a period of time would be useful to make an indirect assessment of the actual disease burden. A cross-sectional survey was done among males aged 15-64 years, to study the prevalence of anthropometric and behavioral risk factors of NCDs. Information was collected on the sociodemographical factors, tobacco use, alcohol intake, diet, salt consumption, and physical activity, using a predesigned and pretested interview schedule. Anthropometric measurements were taken. A study found that prevalence of current smoking and use of smokeless tobacco was 14.2 and 54.9%, respectively. Alcohol intake was present in 22.7% of the study population. Per capita salt consumption per day was 14.6 g. A sedentary lifestyle was present among 19% of the men. Prevalence of overweight and obesity was 8.8% and 9.5%, respectively. Our finding suggested that greater surveillance of the NCD risk factors should be initiated as early as possible, in parallel with surveillance for communicable diseases. Source

Rajasekhar S.S.S.N.,Dhanalakshmi Srinivasan Medical College and Hospital
Biomedicine (India) | Year: 2013

Introduction: Morphological evolution of hip joint is a resultant of bipedal locomotion and erect posture of Humans. Hip joint is the largest joint in the body with maximum stability than gleno-humeral joint owing to the deep insertion of head of femur into the acetabulum (1). Sound knowledge of normal anatomy and possible variations of proximal part of femur especially neck shaft angle of femur is of importance to the orthopedic surgeon. Aim: Aim of the study is to analyze the Neck Shaft Angle. Materials and Methods: 136 dry femora were taken for this study. Angle was measured with the aid of Osteometricboard, Vernier calipers, Card board and Protractor. Results: The neck- shaft angels of 136 femora are measured belonging to normal South Indians, out of which 41 are males and 95 are females. In this series of study the recorded minimum angle is 105° and the maximum, 146°. The average being 129.09°. Estimation of femoral neck shaft angle is important as an increased femoral neck shaft angle is noted in congenital subluxation and dislocation of the hip, poliomyelitis, cerebral palsy and idiopathic scoliosis and a decreased angle is noted in the congenital coxa vara, post traumatic coxa vara due to mal-united femoral neck and inter trochanteric fractures, perthes disease13. It is essential to have more south Indian studies so that the average neck shaft angle of target population will be taken into account while the designing implants for Indians. Source

Swathi M.,Dhanalakshmi Srinivasan Medical College and Hospital
Indian Journal of Leprosy | Year: 2014

Leprosy is a chronic progressive granulomatous disease caused by Mycobacterium leprae. Hepatic involvement is seen in early stages of the disease. Administration of the hepatotoxic drugs like Rifampicin and Dapsone may further deteriorate the liver function. The present study was undertaken to evaluate hepatic status by studying the various liver function tests in leprosy patients and compared to healthy controls. Thirty untreated leprosy patients (18 Multibacillary, 12 Paucibacillary) with duration of illness varying from one month to three years were selected as cases. Twenty healthy age and sex matched persons were taken as controls. Hepatic functional status was evaluated by estimation of serum total bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase, total protein, albumin and globulin. Independent sample ‘t’ test was used to compare the data. P & 0.05 was considered as significant. Except for serum total protein, there was a statistically significant difference between the mean values of all the parameters in cases when compared to controls. The present study revealed minimal derangement in hepatic function in leprosy patients. Therefore monitoring of liver function tests is very important to assess the functional status of the liver before administration of therapy in leprosy. © Hind Kusht Nivaran Sangh, New Delhi. Source

Gupta S.,Dhanalakshmi Srinivasan Medical College and Hospital
Indian Journal of Pharmacology | Year: 2015

There is an urgent need to expedite the time-to-market for new drugs and to make the approval process simpler. But clinical trials are a complex process and the increased complexity leads to decreased efficiency. Hence, pharmaceutical organizations want to move toward a more technology-driven clinical trial process for recording, analyzing, reporting, archiving, etc., In recent times, the progress has certainly been made in developing paperless systems that improve data capture and management. The adaptation of paperless processes may require major changes to existing procedures. But this is in the best interests of these organizations to remain competitive because a paperless clinical trial would lead to a consistent and streamlined framework. Moreover, all major regulatory authorities also advocate adoption of paperless trial. But challenges still remain toward implementation of paperless clinical trial process. © 2015 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow. Source

Arul P.,Dhanalakshmi Srinivasan Medical College and Hospital | Masilamani S.,Dhanalakshmi Srinivasan Medical College and Hospital
Indian Journal of Medical and Paediatric Oncology | Year: 2016

Background: The diagnosis of breast carcinoma can be reliably made by fine needle aspiration cytology (FNAC). Grading usually done in histological samples for the selection of therapy but not in cytology. Various cytological grading systems have been proposed; however, none of them is presently considered the gold standard to predict the prognosis. Aim: This study was undertaken to evaluate various 3-tier cytological grading systems and to determine the best possible system corresponds to the histological grading proposed by Elston and Ellis based on the method by Nottingham modification of Scarff-Bloom-Richardson (SBR) method. Materials and Methods: In this retrospective study, 94 cases of breast carcinoma FNACs were graded using six cytological grading systems and compared with SBR method. Concordance, association, and correlation studies were done to select best possible cytological grading system. The interobserver reproducibility among the six grading systems was also assessed. Results: Robinson method showed best correlation (r = 0.801; P = 0.0001 and t = 0.783; P = 0.0001), maximum percent agreement (83/94 cases; 88.3%), and a substantial kappa value of agreement (k = 0.737) with the Nottingham modification of SBR grading system followed by Mouriguand method. Taniguchi system showed better interobserver agreement (87.2%; k= 0.738). Conclusions: This study showed that all six cytological grading systems correlated positively with SBR method. However, Robinson's grading system demonstrated the best concordance, correlation, and substantial Kappa value of the agreement with the histological grading by SBR method in comparison to other 3-tier cytological grading systems. Hence, in conclusion, this grading should be routinely incorporated in the cytology reports as it correlates well with histological grade. Despite various cytological grading systems, Robinson's method is simple, more objective, and reproducible, hence being preferable for routine use. © 2016 Indian Journal of Medical and Paediatric Oncology. Source

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