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Mumbai, India

Samel A.B.,Dg Ruparel College | Pai N.R.,Dg Ruparel College
Research Journal of Pharmacy and Technology | Year: 2011

2-chloro-4-aminoquinazolines 3a-b were synthesized by intramolecular cyclization of substituted formamide 2a-b in presence of phosphorus oxychloride in one pot. These were further condensed with 5-aryl/alkyl- 2-hydrazino-1,3,4- thiadiazoles 8a-e. synthesized by condensation of hydrazine hydrate with 2-chloro-5-aryl/alkyl-1,3,4-thiadiazoles 7a-e which in turn were obtained by copper mediated diazotization of 2-amino-5-aryl/alkyl-1,3,4-thiadiazoles 6a-e in acetic acid to give various 2-[2-(1,3,4-thiadiazol-2-yl)hydrazinyl] quinazolin-4-amines 9a-l. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. Newly synthesized compounds were screened for their antimicrobial activities. © RJPT All right reserved.

Balakrishnan B.,Dg Ruparel College | Chiplunkar S.V.,Advanced Center for Treatment Research and Education in Cancer | Indap M.M.,Dg Ruparel College
Journal of Osteoporosis | Year: 2014

Marine molluscs are widely distributed throughout the world and many bioactive compounds exhibiting antiviral, antitumor, antileukemic, and antibacterial activity have been reported worldwide. The present study was designed to investigate the beneficial effect of methanol extract of Euchelus asper (EAME) on estrogen deficiency induced osteoporosis in ovariectomised mice model. Forty-two female Swiss albino mice were randomly assigned into Sham operated (Sham) group and six ovariectomised (OVX) subgroups such as OVX with vehicle (OVX); OVX with estradiol (2 mg/kg/day); OVX with EAME of graded doses (25, 50, 100, and 200 mg/kg/day). Bone turnover markers like serum alkaline phosphatase (ALP), serum acid phosphatase (ACP), serum calcium, and histological investigations of tibia and uterus were analysed. Metaphyseal DNA content of the femur bone was also studied. Antiosteoclastogenic activity of EAME was examined. Administration of EAME was able to reduce the increased bone turnover markers in the ovariectomised mice. Histomorphometric analysis revealed an increase in bone trabeculation and restoration of trabecular separation by EAME treatment. Metaphyseal DNA content of the femur of the OVX mice was increased by EAME administration. EAME also showed a potent antiosteoclastogenic behaviour. Thus, the present study reveals that EAME was able to successfully reduce the estrogen deficiency induced bone loss. © 2014 Babita Balakrishnan et al.

Samel A.B.,Dg Ruparel College | Pai N.R.,Dg Ruparel College
Journal of the Chinese Chemical Society | Year: 2010

2-Amino-5-aryl/alkyl-1,3,4-thiadiazoles 3a-e were synthesized from aliphatic and aromatic acids and thiosemicarbazide. These 2-amino-5-aryl/alkyl- 1,3,4-thiadiazoles 3a-e were condensed with 2-(naphthalenyloxymethyl) oxirane 4a-b to prepare some naphthalenyloxy-propanol amine derivatives 5a-j. These compounds were synthesized as potential antihypertensive agents.

Rele R.V.,Dg Ruparel College | Gurav P.J.,Dg Ruparel College
International Journal of Pharma and Bio Sciences | Year: 2012

Simple sensitive and accurate extractive spectrophotometric method was developed for the estimation of loratadine, desloratadine and rupatadine in pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 618 nm,614 nm and 616 nm respectively. The proposed method was validated statistically. Recoveries of method was carried out by standard addition methods. The Beer's lawranges were found to be 1-12 μg/ml, 0.5-3 μg/ml and 0.5-8 μg/ml for loratadine, desloratadine and rupatadine respectively. The low values of standard deviation and percentage RSDindicate high precision of method. Hence the method is useful for routine estimation of loratadine, desloratadine and rupatadine in tablets respectively.

Pai N.R.,Dg Ruparel College | Samel A.B.,Dg Ruparel College
Asian Journal of Chemistry | Year: 2011

Hydroxy-3,4-dihydroquinolin-2(1H)-ones (4a-c) were synthesized by intramolecular Friedel Craft alkylation of N-(methoxyphenyl)-3- chloropropionamides (3a-c), obtained by acylation of anisidine with chloropropionyl chloride. The hydroxy-3,4-dihydro quinolin-2(1H)- ones (4a-c) were treated with various dibromo alkanes under phase transfer catalyst conditions at room temperature to give bromoalkyloxy- 3,4-dihydroquinolin-2(1H)- ones (5a-l) which on further reaction with guanidine hydrochloride in dimethyl formamide afforded N-{4- [(2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy]alkyl} guanidines (6a-l). These compounds were synthesized as potential antihypertensive agents.

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