Park H.K.,Kyung Hee University |
Kim S.K.,Kyung Hee University |
Kweon H.Y.,National Academy of Agricultural Science |
Lee K.G.,National Academy of Agricultural Science |
And 2 more authors.
Saudi Journal of Biological Sciences | Year: 2016
Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of IL4 gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of IL4 gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used. Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values. Nine case-control studies with case and control design were included in this meta-analysis. Overall, meta-analysis revealed a strong association with susceptibility of RA [OR. = 1.303, 95% CI. = 1.093-1.554, P = 0.003 in allele model (C vs. T); OR. = 1.247, 95% CI. = 1.054-1.474, P = 0.010 in dominant model (CC vs. CT + TT); OR. = 2.148, 95% CI. = 1.263-3.651, P = 0.005 in recessive model (CC + CT vs. TT)]. Our data demonstrated that promoter polymorphism (-590, T/C) of IL4 gene may be contributed to susceptibility of RA. However, more studies with a larger sample size are needed to provide more precise evidence. © 2016 The Authors.
Park H.K.,Kohwang Medical Research Institute |
Kim S.K.,Kohwang Medical Research Institute |
Lee S.W.,Development of Ginseng and Medical Plants Research Institute |
Chung J.-H.,Kohwang Medical Research Institute |
And 3 more authors.
Saudi Journal of Biological Sciences | Year: 2015
A recent study reported that Panax ginseng (P. ginseng) has a protective effect on the development of benign prostatic hyperplasia (BPH). KH053 is used as a new herbal prescription consisting of P. ginseng and bee-pollen. The present study aimed to investigate whether the KH053 has inhibition effects on the development of benign prostatic hyperplasia (BPH) using an animal model with testosterone induced BPH. The experiment was carried out in forty male Wistar 7. week old rats that were divided into four groups (control group, BPH group, positive group, and KH053 group). One group was used as the control and the three groups received subcutaneous injections of testosterone 20. mg/kg for 4. weeks to induce BPH. One of them received KH053 by oral gavage daily at doses of 200. mg/kg concurrently with the testosterone. The positive group received finasteride at a dose of 1. mg/kg with testosterone. After 4. weeks, all rats were sacrificed and analyzed for prostate weight, and growth factors. Results revealed that, compared to rats in the BPH group, KH053 showed that the prostate weight and dihydrotestosterone (DHT) levels in serum were significantly decreased and the decreases in hyperplasia in prostate were also observed. In addition, immunohistochemistry (IHC) also revealed that the protein expressions of growth factors [transforming growth factor β1 (TGF-β1) and vascular endothelial growth factor (VEGF)] in prostate tissue were decreased in the KH053 group. In conclusion, these results suggest that KH053, comprising P. ginseng and bee-pollen, inhibits the development of BPH in Wistar rat model and might be used as functional food for BPH. © 2015 The Authors.