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News Article | May 19, 2017

COLLEGE STATION, TX, May 19, 2017-- Troy Holcombe has been included in various Marquis Who's Who volumes. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.A marine geologist with more than five decades of professional experience, Dr. Holcombe demonstrates excellence as a research scientist affiliated with the department of oceanography, Texas A&M University, a role that he has held since joining the department in 2002. Regarded for his work ethic and his passion for his line of work, he came to prominence early in his career working for the U.S. Naval Oceanographic Office as a research oceanographer. Additional noteworthy roles include head of the geology branch at the Naval Ocean Research and Development Laboratory of the Naval Research Laboratories, chief of the marine geology and geophysics division of the National Geophysical Data Center of the National Oceanographic and Atmospheric Administration, and research associate for the Cooperative Institute of Research and Environmental Sciences at the University of Colorado. In recognition of his professional excellence in his career, Dr. Holcombe was selected for inclusion in Who's Who in America, Who's Who in Science and Engineering, Who's Who in the West, Who's Who in the World, and Who's Who of Emerging Leaders in America.To prepare for a career in marine geology, Dr. Holcombe attended Hardin-Simmons University, where he earned a Bachelor of Arts in 1961. Thereafter, he achieved a Master of Arts in geology at the University of Missouri, and a Ph.D. in marine geology from Columbia University in 1972. He has remained at the top of his career by affiliating with a number of professional organizations including the American Association of Petroleum Geologists, the Geological Society of America and the International Association of Great Lakes Research. Considered an expert in his work, Dr. Holcombe has taken on various civic projects in his career that have allowed him to share his insights and experiences with other likeminded professionals. Included in this work was the publication of a number of book chapters and professional articles. Among Dr. Holcombe's more noteworthy achievements includes leading a long-term multi-agency program resulting in Bathymetric Charts of the Great Lakes; and his work on the editorial boards of the IOC (Intergovernmental Oceanographic Commission) International Bathymetric Charts of the Gulf of Mexico and the Caribbean, the Western Indian Ocean, the Central Eastern Atlantic and the Mediterranean. He also co-authored a landmark paper on the geology of the Caribbean, entitled "Evidence for Sea-Floor Spreading in theCayman Trough." Dr. Holcombe also co-authored the "Geologic-Tectonic Map of the Caribbean Region," published by the U. S. Geological Survey, and he contributed the Caribbean portion of the "Geologic Map of North America," compiled by the Geological Society of America and also published by the U. S. Geological Survey. Looking ahead to the future, Dr. Holcombe intends to continue with several projects working with professors and students in the department of oceanography at Texas A&M University, primarily on aspects of the geology of the northwestern Gulf of Mexico.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis now publishes many Who's Who titles, including Who's Who in America , Who's Who in the World , Who's Who in American Law , Who's Who in Medicine and Healthcare , Who's Who in Science and Engineering , and Who's Who in Asia . Marquis publications may be visited at the official Marquis Who's Who website at Contact:Fred Marks844-394-6946

News Article | May 23, 2017

Behlman Electronics, Inc., known for its leadership in providing power products for military, industrial, and commercial applications worldwide, has introduced a new, high-performance interface to three of its P-Series AC Power Sources. Called Option U, this high-performance interface includes USB, Ethernet, and RS-232 Interface using SCPI protocol. This option enables faster communication speed, programming the power supply remotely from greater distances, and compatibility with newer computers. Behlman’s Option U high-performance interface is available on their Models P1352, P2002, and PF1352. The PF1352 is power factor corrected, and carries the CE Mark essential for users in member states of the EU and EFTA, including Iceland, Norway, Switzerland and Liechtenstein, plus Turkey. According to Behlman President, Ron Storm, “Our P-Series AC Power Supplies/Frequency Converters have been continuously improved, by adding performance features requested by our customers around the world. In 2013, we added the CE Mark to our offerings, with the introduction of new Models PF1350, PF1351, and PF1352. Our goal is to expand the utility of our very popular USA models, so that engineers and technicians everywhere can perform their mission-critical and essential industrial tasks more readily, with ultimate reliability. Now with the addition of Option U, we provide more valuable interface enhancements that keep us on the leading edge of the latest AC Power technology.” Model PF1352 is perhaps the most versatile in Behlman’s line of P-Series AC Power Sources. It provides PFC input, fully adjustable voltage and frequency, low-output THD, unique overload protection, high-efficiency, excellent line and load regulation. Remote programming via standard RS232, and now, with Option U, remote programming via RS232/USB/Ethernet or, using Option 1 IEEEE-488. Its CE Mark is evidence of its worldwide capabilities. Like all units in Behlman’s P-Series, it can be used on a table top, or mounted in a 19” rack. The PDF comparison chart attached to this news release provides key data on the entire Behlman line of P-Series AC Power Sources / Frequency Converters. Complete details and data sheets are immediately available at Model P1350; Power 1350 VA; Output VAC (RMS) 0-135, 0-270; Output Amps 10, 5; Output Frequency Fixed @ 50, 60 and 400    Hz; Input Volts 10 VAC 120; Dimensions (19’ rack mount) 3.5” H x 17.5” D; Three fixed frequencies and variable voltage. Model PF1350; Power 1350 VA; Output VAC (RMS) 0-135, 0-270; Output Amps 10, 5; Output Frequency Fixed @ 50, 60 and 400    Hz; Input Volts 10 VAC 95-270; Dimensions (19’ rack mount) 3.5” H x 21” D; Three fixed frequencies and variable voltage with CE Mark. Model PF1352*; Power 1350 VA; Output VAC (RMS) 0-135, 0-270; Output Amps 10, 5; Output Frequency 45-500 Hz; Input Volts 10 VAC 95-270; Dimensions (19’ rack mount) 3.5” H x 21” D; Variable voltage and frequency with CE Mark, plus RS-232. *P1352, P2002, and PF1352 ¬also offer Option U, which includes, USB, Ethernet, and RS-232 Interface using SCPI protocol. (This option enables faster communication speed, programming power supply from greater distances, and compatibility with newer computer systems.) Optional IEEE-488 is also available on the Behlman P1351, P1352, P2002, PF1351, and PF1352. WHY AN AC POWER SOURCE/FREQUENCY CONVERTER IS ESSENTIAL. During the development and testing of military, industrial and consumer products, if the product to be tested is plugged directly into any standard factory AC main, there is a possibility that the power being used could corrupt the test. This can affect the performance of the equipment being tested, causing its functionality to appear be on-spec, when it is off -spec, or off-spec when it is on-spec. Either way, such false test results can be costly due to the need for additional engineering to fix a non-problem, or worse, the cost of having to fix faulty units in the field, thus losing customer confidence. A regulated electronic AC power source/frequency converter can solve this and many other power quality issues, while providing additional testing flexibility. Behlman Electronics Inc., (, a subsidiary of Orbit International Corp., manufactures and sells high-quality standard, modified-standard, custom and COTS power solutions, including AC power supplies, frequency converters, inverters, DC-DC, AC-DC, DC-AC, uninterruptible power supplies, and tthe VPXtra® line of VPX/VME Power Supplies. Orbit International Corp., based in Hauppauge, New York, is involved in the manufacture of customized electronic components and subsystems for military and nonmilitary government applications. Other subsidiaries and divisions include Orbit Instrument, Tulip Development Laboratory, and Integrated Combat Systems, all of which are members of the Orbit Electronics Group. For more information, contact Behlman Electronics Inc., 80 Cabot Court, Hauppauge, New York 11788 USA; TEL: +1 631 435-0410; FAX: +1 631 951-4341; sales(at)behlman(dot)com;

Borbas E.,Budapest University of Technology and Economics | Balogh A.,Budapest University of Technology and Economics | Bocz K.,Budapest University of Technology and Economics | Muller J.,Budapest University of Technology and Economics | And 9 more authors.
International Journal of Pharmaceutics | Year: 2015

Abstract Since it is a well-known fact that among the newly discovered active pharmaceutical ingredients the number of poorly water soluble candidates is continually increasing, dissolution enhancement of poorly water soluble drugs has become one of the central challenges of pharmaceutical studies. So far the preclinical studies have been mainly focused on formulation methods to enhance the dissolution of active compounds, in many cases disregarding the fact that the formulation matrix not only affects dissolution but also has an effect on the transport through biological membranes, changing permeation of the drug molecules. The aim of this study was to test an electrospun cyclodextrin-based formulation of aripiprazole with the novel μFlux apparatus, which monitors permeation together with dissolution, and by this means better in vitro-in vivo correlation is achieved. It was evinced that a cyclodextrin-based electrospun formulation of aripiprazole has the potential to ensure fast drug delivery through the oral mucosa owing to the ultrafast dissolution of the drug from the formulation and the enhanced flux across membranes as shown by the result of the novel in vitro dissolution and permeation test. © 2015 Elsevier B.V.

Varga G.,ChiroQuest Chiral Technologies Development Ltd. | Tarkanyi G.,Hungarian Academy of Sciences | Nemeth K.,Hungarian Academy of Sciences | Ivanyi R.,Development Laboratory Ltd. | And 6 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2010

Preparation of (6-monoureido-6-monodeoxy) permethylated β-cyclodextrin bonded chiral stationary phase from permethylated 6-monoamino-6-monodeoxy-β-cyclodextrin is described. The optimized chiral stationary phase was evaluated by using HPLC separation of racemates of coumarin derivatives. Column characterization was performed by solid-state 13C, 15N, 29Si NMR using cross-polarization at the magic angle spinning. The development process was supported by CE experiments where the complex formation between cyclodextrins and warfarin was investigated. The results demonstrate good enantio-discrimination for coumarin derivatives. © 2009 Elsevier B.V. All rights reserved.

Gutay-Toth Z.,Debrecen University | Fenyvesi F.,Debrecen University | Barsony O.,Debrecen University | Szente L.,Development Laboratory Ltd. | And 3 more authors.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids | Year: 2016

The 15D3 mouse monoclonal antibody (mAb) binds an uncharacterized extracellular epitope of the ATP Binding Cassette (ABC) transporter human P-glycoprotein (Pgp). Depletion of cell plasma membrane cholesterol by using methyl-β-cyclodextrin or other chemically modified β-cyclodextrins decreased the Pgp binding affinity of 15D3 mAb. UIC2 mAb, which is known to distinguish two conformers of this ABC transporter, binds only a fraction of cell surface Pgps. UIC2 mAb non-reactive pools of Pgp can be identified with other extracellular mAbs such as 15D3. Cyclosporin A (CsA) can shift non-reactive Pgps into their UIC2-reactive conformation: a phenomenon called the "UIC2 shift". Competition studies proposed these two mAbs share overlapping epitopes and can reveal conformational changes of Pgp that correlate (r = 0.97) with the cholesterol content of cells. An apparent increase in competition of these mAbs suggested a conformational change similar to those found in the presence of CsA. However, the reason turned out not to be the UIC2-shift because cholesterol removal from the plasma membrane (PM) reduced the amount of detectable Pgps by 15D3 mAb. This study showed that 15D3 mAb bound to a conformation sensitive epitope of Pgp that was responsive to PM cholesterol levels. These conformational changes were gradual and not as great as the changes observed between the two conformers recognized by the UIC2 mAb. © 2015 Elsevier B.V. All Rights Reserved.

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