Development Center for New Materials Engineering and Technology in Universities of Guangdong

Zhanjiang, China

Development Center for New Materials Engineering and Technology in Universities of Guangdong

Zhanjiang, China
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Chen B.,Zhanjiang Normal University | Chen B.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Zhang Y.,Zhanjiang Normal University | Xie H.-L.,Zhanjiang Normal University | And 2 more authors.
Journal of the Chinese Chemical Society | Year: 2014

We describe a chiral separation method for ofloxacin enantiomers, levofloxacin and dextrofloxacin by microchip capillary electrophoresis with capacitively coupled contactless conductivity detection. The running buffer included 1 mmol L-1 MES and 1 mmol L-1 Tris (pH 8.0) with a separation voltage of 1.5 kV and an injection time of 10s. Under these conditions, the enantiomers were completely separated within 1 min. The linear calibration curves were A = 5.76 c - 0.00587 for levofloxacin and A = 5.41 c - 0.00551 for dextrofloxacin, in which the linear concentration of the components all ranged from 0.05 to 0.15 mg mL-1 (regression coefficients were both 0.9996). The limits of detection (S/N = 3) were, respectively, 18 and 21 μg mL-1. The relative standard deviations of migration time were both 2.0% (n = 6). The relative standard deviations of peak area were 3.4% (n = 6) for levofloxacin and 4.0% (n = 6) for dextrofloxacin. The effects of some factors on resolutions, such as separation voltage and injection time, concentration of running buffers, were studied. The method was simple, rapid, high-efficient. Furthermore, the method could be applied to the chiral separation of the product containing these enantiomers, such as Ofloxacin Eye Drops. Ofloxacin enantiomers, levofloxacin and dextrofloxacin in Ofloxacin Eye Drops were separated by microchip capillary electrophoresis with capacitively coupled contactless conductivity detection. The proposed method is a simple and scientific innovation to evaluate and control the quality of fluoroquinolones antibiotic drugs. Copyright © 2014 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.


Tang X.S.,Zhanjiang Normal University | Tang X.S.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Wang H.J.,Zhanjiang Normal University | Feng L.,Zhanjiang Normal University | And 4 more authors.
Applied Surface Science | Year: 2014

Mo (molybdenum) doped diamond like carbon (Mo-DLC) coatings with improved mechanical and blood compatibility properties were deposited by closed field unbalanced magnetron sputtering. The undoped and Mo-doped DLC coatings were analyzed by various characterization techniques such as Raman spectra, Atomic force microscopy, and temperature-dependent frictional wear testing. The results showed that the Mo-DLC coating with low Mo concentration was a effective protective coating with reduced residual stress and increased cohesive strength, and kept good wear resistance at the ambient temperature of 500 °C. The blood compatibility of Mo-DLC coatings was investigated by platelet adhesion. The results showed that the amount of thrombus on the Mo-DLC nanocomposite coatings was much less than that of thrombus on pyrolytic carbon films. The Mo-DLC nanocomposite coatings would be a new kind of promising materials applied to artificial heart valve and endovascula stent. © 2014 Elsevier B.V.


Chen B.,Zhanjiang Normal University | Chen B.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Mai Q.,Zhanjiang Normal University | Chen Q.,Zhanjiang Normal University
Journal of Liquid Chromatography and Related Technologies | Year: 2014

A method of microfluidic chip with contactless conductivity detection has been developed for the determination of ofloxacin in Ofloxacin Ear Drops. Electrophoresis conditions included a buffer of 1m mol L-1L-Histidine (pH 6.5) with 1m mol L-1 2-(N-Morpholino)ethanesulfonic acid (MES), an applied voltage of 1.5 kV, and an injection time of 10s with a voltage of 500V. Under optimum conditions, the component was determined within 0.7min, allowing detection of ofloxacin in Ofloxacin Ear Drops. The regression equation was y = 669767x-1364.4 and the square of correlation coefficients (r 2) was 0.9997. The linear range of the component was from 0.1 to 0.8 mg mL-1. The relative standard deviations (RSD, n = 3) for migration time and peak area were 0.9%and 4.0%, respectively. The detection limit (S/N = 3), 21.2 mg L-1, was low. The average recovery of the component was 101.7%(RSD = 4.6%, n = 3) by this method. This developed method is rapid, high efficient, sensitive, economical, and capable of the determining the active ingredient in Ofloxacin Ear Drops. © 2014 Copyright Taylor & Francis Group, LLC.


Song X.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Song X.,South China Normal University | Feng Z.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Feng Z.,University of Sichuan | And 4 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2014

Starting from 2-aminophenol and resorcinol, 2, 4, 2'-trihydroxy azobenzene was synthesized via diazo and coupling reaction, and its structure was determined by FT-IR, 1H-NMR, 13C-NMR, electrospray ionization mass spectrometry (ESI-MS) and element analysis. Then polymethyl methacrylate (PMMA) film doped with 2, 4, 2'-trihydroxy azobenzene was produced by physical method. The photoisomerization properties in tetrahydrofuran (THF) and polymethyl methacrylate were studied by UV-vis spectrum, plus kinetics in different organic solvents. The results show that the title compound displays significant photoisomerization in THF and PMMA irradiated by UV light (λ=365 nm). The cis-isomer product has a high yield, excellent thermostability and photostability. The tran-cis isomerization is a first-order reaction. Isomerization speed constant values decrease with increasing polarity of the organic solvents.


Feng Z.-C.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Feng Z.-C.,University of Sichuan | Song X.-M.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Jiang S.-Y.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Huang G.-X.,Development Center for New Materials Engineering and Technology in Universities of Guangdong
Guangzi Xuebao/Acta Photonica Sinica | Year: 2013

Using 4-((3, 4-dihydroxyphenyl)diazenyl) benzenesulfonic acid and 4, 4'-diphenyl- methane diisocyanate (MDI) as raw materials, the hyperbranched azo polyurethane was synthesized by A2+B3 polycondensation, with the reactions between phenolic hydroxy or sulfo group and isocyanate group. Then the peripheral hydroxyls of synthetic hyperbranched azo polyurethane reacted with succinic anhydride or trimellitic anhydride to to improve the polymer solubility. The target hyperbranched azo polyurethanes were characterized by IR, TG and UV-Vis spectrum. The UV-Vis spectra showed that both of the maximum absorption peaks of π→π* in the unmodified hyperbranched azo polyurethane and the hyperbranched azo polyurethane modified by trimellitic anhydride were the same, at 425 nm, while the maximum absorption peak of π→π* in hyperbranched azo polyurethane modified by succinic anhydride was red shifted to 501 nm.


Feng Z.,University of Sichuan | Feng Z.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Song X.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Wang Y.,University of Sichuan | And 3 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2013

Hyperbranched base-dissolved photosensitive polyesters were synthesized by esterification of carboxyl and hydroxyl groups of adipic acid and trimethylol propane, then reacting the peripheral carboxyls of synthesized polymer molecules with glycidyl methacrylate. The tracks of reacting course were followed by acid value change of reacting system. The effects of the component of resins on sensitivity and alkali solubility were studied. The results show that alkali solubility depends on the acid value of resin and the percentage of adipic acid chain section. Photocuring behaviors of resins are related to -COOH/-OH molar ratio and peripheral photo-group of synthesized polymer molecules. Fairly good alkali solubility and photocuring can be gained through adjusting the proportion of reactants.


Feng Z.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Feng Z.,University of Sichuan | Song X.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Wang Y.,University of Sichuan | And 2 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2013

Starting from 2, 4, 2'-trihydroxy azobenzene and succinic acid, the hyperbranched azo polyester was synthesized by the reaction of succinyl chloride and hydroxy via A2+B3 polycondensation. The structure of the hyperbranched azo polyester was characterized by IR, TG, and its photochromic property was tested by UV-Vis spectrum. The results reveal that the hyperbranched azo polyester and 2, 4, 2'-trihydroxy azobenzene has the same π-π* warp maximum absorption peak, which does not be affected by the structure of the polymer. With the increasing of azo unit in polymer, the reaction rate of trans-cis isomerization which is larger than that of the monomer increases. The target polymer has a good thermal stability within 200°C.


Feng Z.-C.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Li L.,South China University of Technology | Deng F.-J.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Wei L.,Development Center for New Materials Engineering and Technology in Universities of Guangdong | Liu X.-Y.,Development Center for New Materials Engineering and Technology in Universities of Guangdong
Yingxiang Kexue yu Guanghuaxue/Imaging Science and Photochemistry | Year: 2010

Hyperbranched base-dissolved photosensitive polyesters were synthesized from 1,2, 4-trimellitic anhydride and ethylene glycol and glycidyl methacrylate. By using the peripheral carboxyls of synthesized polymer molecules and allyl glycidyl ether reacting together, leading reactive trimethylopropane diallyl enther into the periphery of extra polymer molecules, the effects of the component of resins on sensitivity and alkali solubility were studied. The result shows that fairly good alkali solubility and photocuring can be gained through adjusting the proportion of reactants.

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