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Shanghai, China

Yang H.,Dalian University of Technology | Mu Y.,Dalian University of Technology | Chen H.,Dalian University of Technology | Xiu Z.,Dalian University of Technology | And 2 more authors.
Food Chemistry | Year: 2013

Feruloylated lysophospholipids (FLPs) were firstly synthesized from phosphatidylcholine (PC) and ethyl ferulate (EF) using lipase-catalysed interesterification in selected solvents at controlled water content. Kinds of lipases and single solvents were screened. Novozym 435 and toluene were found to be the suitable biocatalyst and solvent, respectively. Then tert-butanol, n-butanol, chloroform, isopropanol, acetone and DMSO were respectively added into toluene in order to increase conversion of products. The results showed that toluene/chloroform could significantly increase the conversion and the optimal combination of toluene and chloroform was 90:10 (v/v). The optimal conditions generated for FLPs production were a substrate molar ratio of 5:1 (PC/EF), a PC's hydrolytic time of 1.5 h, an enzyme load of 60 mg/ml, a solvent dosage of 5 ml and a molecular sieves concentration (4 Å) of 100 mg/ml. Under these conditions, 40.51% of EF can be converted to FLPs, which were identified by TLC and HPLC-MS. © 2013 Elsevier Ltd. All rights reserved. Source

Miklos R.,Copenhagen University | Zhang H.,University of Aarhus | Zhang H.,Development Center Co. | Lametsch R.,Copenhagen University | Xu X.,University of Aarhus
Food Chemistry | Year: 2013

The objective of the study was to investigate how blending of triacylglycerols and diacylglycerols affected the melting and crystallisation properties in a solid fat system. Lard-based diacylglycerols (DAGs) were blended with lard in various concentrations (0%, 1%, 5%, 10%, 20%, 50%, 60%, 70%, 80%, 90%, and 100%). The melting and crystallisation properties were investigated by the determination of dropping point (DP), solid fat content (SFC), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In general, the effects of DAGs were found to be dependent on concentration. The DP was significantly (P < 0.0001) decreased when DAGs were added to the lard from 5-50%, whereas the DP was increased (P < 0.0001) when the blends contained more than 60% DAGs. The DSC thermograms showed that DAGs changed the melting and crystallisation profiles of lard. The crystallisation onset point increased (P < 0.05) with increasing the DAG concentrations (10-100%). The melting peaks and off-set points generally shifted slightly towards higher temperatures as the content of DAGs increased above 50%. DAG content of 5% and 10% resulted in lowering of the off-set point. The lard contained both β and β′ crystals. The β form was more pronounced in the blends with high concentrations of DAGs. Blending of TAGs and DAGs may serve as a solution to achieve specific functional properties in products containing solid fats. © 2012 Elsevier Ltd. All rights reserved. Source

Development Center Inc. | Date: 1999-01-19

computer software used to assess personality traits and leadership capacities. booklets and printed survey answer sheets in the field of leadership and personality assessment.

Liu R.,Development Center Co. | Wang Y.,Development Center Co. | Baba T.,Fujitsu Limited | Masumoto D.,Fujitsu Limited
Pattern Recognition | Year: 2010

An object detection method from line drawings is presented. The method adopts the local neighborhood structure as the elementary descriptor, which is formed by grouping several nearest neighbor lines/curves around one reference. With this representation, both the appearance and the geometric structure of the line drawing are well described. The detection algorithm is a hypothesis-test scheme. The top k most similar local structures in the drawing are firstly obtained for each local structure of the model, and the transformation parameters are estimated for each of the k candidates, such as object center, scale and rotation factors. By treating each estimation result as a point in the parameter space, a dense region around the ground truth is then formed provided that there exist a model in the drawing. The mean shift method is used to detect the dense regions, and the significant modes are accepted as the occurrence of object instances. © 2009 Elsevier Ltd. All rights reserved. Source

Kukulka M.,Development Center Co. | Wu J.,Development Center Co. | Perez M.C.,Development Center Co.
Journal of Pediatric Gastroenterology and Nutrition | Year: 2012

Objectives: Dexlansoprazole MR 30mg once daily (QD) is approved in adults for the treatment of symptomatic nonerosive gastroesophageal reflux disease (GERD) and maintenance of healed erosive esophagitis (EE); 60mg is approved for healing EE. The present study assesses the pharmacokinetic (PK) profile and safety of dexlansoprazole MR in adolescent patients. Patients and Methods: Phase 1, open-label, parallel-group, multicenter study in male and female adolescents (12-17 years) with GERD. Patients were randomized to receive dexlansoprazole MR (30 or 60mg, QD) for 7 days. Blood samples to determine dexlansoprazole plasma concentrations were drawn over a 24-hour period after dosing on day 7. Dexlansoprazole plasma concentrations and PK parameters were summarized by dose group. Safety assessments included monitoring of adverse events (AEs). Results: Thirty-six patients (mean age 14.6 years), 14 boys and 22 girls, were randomized, with PK data available for 35 patients. The overall exposure of dexlansoprazole after administration of the 60-mg capsule was slightly less than double the exposure from the 30-mg capsule. Cmax (691 and 1136ng/mL) and area under the plasma concentration time curve (2886 and 5120ng•h/mL) values for the 30- and 60-mg doses, respectively, were similar to results from previous phase 1 studies in healthy adults. Twelve of 36 patients (33.3%) experienced a total of 21 treatment-emergent AEs. All of the AEs were considered to be of mild severity. Conclusions: The PK data for dexlansoprazole MR 30- and 60-mg capsules in adolescent patients with symptomatic GERD were similar to those in healthy adults. Both doses were well tolerated. Copyright © 2012 by European Society for Pediatric Gastroenterology. Source

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