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Virudhunagar District, India

Raji S.,Islamiah College | Kamil S.R.M.,Islamiah College | Subbaraj P.,Devanga Arts College Autonomous
Asian Journal of Chemistry | Year: 2015

A series of novel potent hetero aromatic nitrogen ring of imidazo[2,1-d][1,2,3,5]tetrazine-4(3H)-one derivatives (1a-1i) have been synthesized from 5-propylthio-2-diazo-2H-benzimidazole with substituted isocyanates. The synthesized compounds were structurally characterized by using various analytical and spectral techniques. In vitro microbial activities of the ligands were screened against some pathogenic bacterial and fungal species by modified well diffusion method using agar medium. All the synthesized compounds show significant biological activity as compared to the standard control drugs. Furthermore, antiproliferative activities of these compounds have been investigated against some breast (MCF-7), prostate (PC-3), lung (H1975) and colon (HCT-116) cancer cell lines. The compound (1b) showed a noticeable antiproliferative activity against the entire cell lines than the others.


Subbaraj P.,Devanga Arts College Autonomous | Ramu A.,Madurai Kamaraj University | Raman N.,Vhnsn College Autonomous
Journal of Saudi Chemical Society | Year: 2015

A new bidentate NO type Schiff base ligand (HL), derived from 2-hydroxy-4-methoxyphenyl)phenylmethanone with aniline and its metal(II) [M = Mn, Co, Ni, Cu and Zn] complexes has been synthesized. The synthesized ligand and the metal(II) complexes were structurally characterized by analytical, spectral (FT-IR, UV-vis., 1H NMR, FAB-Mass, TGA/DTA and EPR) as well as molar conductance and magnetic studies. All the complexes are non-electrolytes having 1:2 stoichiometry. They adopt tetrahedral and octahedral geometry. Thermal behavior of metal(II) complexes (1a-1c) shows loss of coordinated water molecules in the first step followed by the decomposition of ligand moieties in a respective manner and leads to form an air stable metal oxide as the final residue. Micro crystalline nature and the presence of coordinated water molecules have been confirmed by powder XRD, SEM and thermal analyses. The ligand and its complexes have efficient bio-efficacy, DNA binding and cleavage ability. © 2014 King Saud University.


Subbaraj P.,Devanga Arts College Autonomous | Esakkidurai T.,Devanga Arts College Autonomous | Shobana S.,Rajas Institute of Technology for Women | Raji S.,Islamiah College Autonomous
Acta Chimica Slovenica | Year: 2014

Mixed ligand complexation of 2-aminobenzamide (2AB) as ligand [L] with Zn(II) in the presence of some bio-relevant amino acid constituents like glycine (gly), L-alanine (ala), L-valine (val) and L-phenylalanine (phe) as ligand [B] have been investigated using pH-metric measurements with a combined pH electrode at different temperatures (300, 310, 320 and 330 ± 0.1 K) in 50% (v/v) ethanol-water mixture containing I = 0.15 M NaClO4 as supporting electrolyte. Computer assisted analysis of the experimental titration data showed the presence of ZnLB and ZnLB2 species as mixed ligand complexes in addition to various binary species. In ZnLB/ZnLB2 species, both primary and secondary ligands act as bidentate to form a stable six, five membered chelate ring. The calculated stabilization parameter Δlog K, log X, log X' and % R.S. values clearly show the mixed ligand complexes have higher stabilities than their binary. Thermodynamic parameters ΔG, ΔH and ΔS have been derived from the temperature dependence of the stability constants. The complexation behavior of ZnLB species has been studied by means of electronic spectra. The percentage distribution of various binary and mixed ligand species of each type of the complexes in solution depending on pH and the ratio of Zn(II) to 2-aminobenzamide/amino acid of the systems.


Subbaraj P.,Devanga Arts College Autonomous | Esakkidurai T.,Devanga Arts College Autonomous | Shobana S.,Rajas Institute of Technology for Women
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2014

A series of novel bioactive mixed ligand Ni(II) complexes (1a-1d) have been synthesised by using 2-aminobenzamide (2AB) and some bio-relevant amino acid ligands. The synthesised Ni(II) complexes were structurally characterized by various physico-chemical and spectral studies. Elemental analysis and molar conductance values suggest that 1:1:1 stoichiometry with non-electrolytic nature. Based on the spectral studies, both the ligands act as bidentate and they chelate with Ni(II) ion via amino-NH2 and amido-O and deprotonated carboxylato-O and amino-NH2 atoms respectively to form a stable six, five membered chelate rings with mononuclear octahedral geometry. Thermal studies show the presence of coordinated water and acetate molecules in the coordination. The powder X-ray diffractogram and SEM pictograph imply that all the complexes have fine crystalline peaks with homogeneous surface morphology. In vitro antimicrobial and antioxidant studies indicate the complexes are more active than free 2-aminobenzamide ligand. The Ni(II)-2AB-gly/phe complexes (1a and 1d) show significant oxidative cleavage and DNA binding activities. Moreover, the 3D molecular modeling, analysis of the complexes has also been studied. © 2014 Elsevier B.V. All rights reserved.


Esakkidurai T.,Devanga Arts College Autonomous | Subbaraj P.,Devanga Arts College Autonomous | Shobana S.,Pioneer India
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Mixed ligand Cu(ii) complexes of 2-aminobenzamide (2AB) and amino acids viz., glycine (gly), L-alanine (ala), L-valine (val) and L-phenylalanine (phe) have been synthesised and characterized by various physico-chemical and spectral techniques. The calculated g-tensor values for Cu(ii) complexes at 77 K and 300 K, show the distorted octahedral geometry which has been confirmed from the absorption studies. Consequently, the thermal studies illustrate that the loss of water and acetate molecules in the initial stage which are followed by the decomposition of organic residues. The powder X-ray diffraction and SEM analysis reflect that all the complexes have well-defined crystallinity nature with homogeneous morphology. The binding activities of CT DNA with CuAB complexes have been examined by absorption studies. Further, the oxidative cleavage Interactions of 2-aminobenzamide and CuAB complexes with DNA were studied by gel electrophoresis method in H2O2 medium. Also, the complex formation of Cu(ii) involving 2-aminobenzamide and amino acids were carried out by a combined pH-metric and spectro-photometric techniques in 50% (v/v) water-ethanol mixture at 300, 310, 320 and 330±0.1 K with i= 0.15 mol dm 3 (NaClO4). in solution, CuAB and CuAB2 species has been detected and the binding modes of 2-aminobenzamide and amino acids in both binary and mixed ligand complexes are same. The calculated stabilization value of δ log K, log X and log X′ indicates higher stabilities for the mixed ligand complexes rather than their binary species. The thermodynamic parameters like δG, DH and DS have been determined from temperature dependence of the stability constant. in vitro biological activities of 2-aminobenzamide, CuA and CuAB complexes show remarkable activities against some bacterial and fungal strains. The percentage distribution of various binary and mixed ligand species in solution at dissimilar pH intervals were also evaluated. © 2013 Elsevier B.V. All rights reserved.

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