Desenvolvimento e Inovacao
Desenvolvimento e Inovacao
Semenzim V.L.,São Paulo State University |
Basso G.G.,São Paulo State University |
Da Silva D.A.,São Paulo State University |
De Vasconcellos A.,São Paulo State University |
And 5 more authors.
Journal of Applied Polymer Science | Year: 2011
Biodegradable polymeric microspheres can be used to deliver drugs through controlled rate and targeted processes. The drug is released from the particles by drug leaching or degradation of the polymeric matrix. Crystallinity can play a very important role in the degradation of polymeric matrixes; it can affect the drug-release rate, especially in chemoembolization. Most commercial embolic agents have a low degree of crystallinity, and the correlation between the drug-delivery rate and the degree of crystallinity is not fully understood. This study presents the appropriated synthesis conditions for the preparation of highly crystalline poly(vinyl alcohol) and poly(vinyl alcohol)/poly(vinyl acetate) microspheres and physicochemical characterizations by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and cross-polarization/magic angle spinning nuclear magnetic resonance. © 2011 Wiley Periodicals, Inc.
Tagliari M.P.,Federal University of Santa Catarina |
Granada A.,Federal University of Santa Catarina |
Segatto Silva M.A.,Federal University of Santa Catarina |
Stulzer H.K.,Federal University of Santa Catarina |
And 7 more authors.
Quimica Nova | Year: 2015
In this study, nifedipine (NFP)-loaded polymeric nanocapsules were prepared and characterised with a view to protect the drug from degradation. Nanocapsule suspensions were prepared using two different surfactants (pluronic F68 and polyvinyl alcohol). Physicochemical stability and in vivo antihypertensive effect were evaluated. The particle size, zeta potential and entrapment efficiency remained constant during a period of 28 days of exposure under light irradiation. A smaller particle size and a higher zeta potential were obtained for the nanocapsules prepared with Pluronic F68 as surfactant. The solid drug and the nanocapsules were submitted to light exposure for 28 days. After this period of time, the percentage of drug remaining in the PF68NFP and PVANFP nanocapsules was 28.1% and 21.3%, respectively. In contrast, the solid drug was completely degraded after 4 days, suggesting that the nanocapsule suspensions promoted significant protection of the drug against light exposure. In addition, in vivo studies were carried out, which demonstrated that the formulations with polyvinyl alcohol exhibited a very rapid onset of action after oral administration in rats and led to faster drug release. The nanoparticles developed can be considered as an alternative for improving NFP stability in liquid formulations. © 2015, Sociedade Brasileira de Quimica. All rights reserved.