Xi Y.,Depurtment of Pathology |
Chat F.,Depurtment of Pathology |
Li J.,Depurtment of Pathology |
Bui W.,Depurtment of Pathology
Journal of Leukemia and Lymphoma | Year: 2014
Objective To study clinicopathologic features of ALK-positive large B-cell lymphoma. Methods The clinical data, histopathological characteristics, immunophenotype and fluorescence in situ hybridization result of a patient with anaplasitic lymphoma kinase(ALK)-positive large B-cell lymphoma were analyzed and discussed combined with related literatures. Results One case, a 30-years-old man with the left neck lymphadenectasis was studied. Histological evaluation revealed the tumor growed in sheets in the nodal, with round nuclei, dispersed chromatin, a single and prominent and central nucleolus and moderate amounts of eosinophilic to amphophilic cytoplasm. The neoplastic cells exhibited immunoblastic/plasmablastic morphology. Immunohistochemistry measurement showed that the tumor cells were marked positively by CD138, ALK-1, CD45RO, CD4, Perforin, CD117 and Kappa proteins, while negatively by CD3, CD8, CD20, CD30, CD38, CD57, CD79a, Pax-5, EMA and AE1/AE3 proteins. FISH test demonstrated the presence of ALK gene translocation. The patient was given 4 cycles of CHOP chemotherapy after surgery. However, the conditions deteriorated after 4 months. Now the patient continued to receive treatment. Conclusion ALK-positive large B-cell lymphoma represents a distinct variant of diffuse large B-cell lymphoma, and the tumor has a special histological features along with a distinct immunophenotype and ALK gene rearrangement. © 2014 Journal of Leukemia & Lymphoma.