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Saint-André-lez-Lille, France

Leroy T.,Departement University Of Radiotherapie | Leroy T.,Lille University of Science and Technology | Gabelle Flandin I.,Grenoble University Hospital Center | Habold D.,Center Hospitalier Of Chambery | And 2 more authors.
Cancer/Radiotherapie | Year: 2012

The aim of this study was to evaluate the impact of radiation therapy on sexual life. The analysis was based on a Pubmed literature review. The keywords used for this research were "sexual, radiation, oncology, and cancer" After a brief reminder on the anatomy and physiology, we explained the main complications of radiation oncology and their impact on sexual life. Preventive measures and therapeutic possibilities were discussed. Radiation therapy entails local, systematic and psychological after-effects. For women, vaginal stenosis and dyspareunia represent the most frequent side effects. For men, radiation therapy leads to erectile disorders for 25 to 75% of the patients. These complications have an echo often mattering on the patient quality of life of and on their sexual life post-treatment reconstruction. The knowledge of the indications and the various techniques of irradiation allow reducing its potential sexual morbidity. The information and the education of patients are essential, although often neglected. In conclusion, radiation therapy impacts in variable degrees on the sexual life of the patients. Currently, there are not enough preventive and therapeutic means. Patient information and the early screening of the sexual complications are at stake in the support of patients in the reconstruction of their sexual life. © 2012 Société française de radiothérapie oncologique (SFRO). Source


Boydev C.,University of Valenciennes and HainautCambresis | Boydev C.,Ecole Polytechnique Federale de Lausanne | Pasquier D.,Departement University Of Radiotherapie | Derraz F.,University of Valenciennes and HainautCambresis | And 4 more authors.
Journal of Physics: Conference Series | Year: 2014

We evaluated automatic three-dimensional intensity-based rigid registration (RR) methods for prostate localization on CBCT scans and studied the impact of rectum distension on registration quality. 106 CBCT scans of 9 prostate patients were used. Each one was registered to the planning computed tomography (CT) scan using different methods: (a) global registration, (b) pelvis bony structure registration, (c) bony registration refined by a local prostate registration using the CT clinical target volume (CTV) expanded with 1, 3, 5, 8, 10, 12, 15 or 20-mm margin. Automatic CBCT contours were generated after propagation of the manual CT contours. To evaluate results, a radiation oncologist was asked to manually delineate the CTV on the CBCT scans (gold standard). The Dice similarity coefficients between propagated and manual CBCT contours were calculated. © Published under licence by IOP Publishing Ltd. Source


Vautravers-Dewas C.,Charles de Gaulle University - Lille 3 | Vautravers-Dewas C.,Departement University Of Radiotherapie | Dewas S.,Charles de Gaulle University - Lille 3 | Bonodeau F.,Center Oscar Lambret | And 5 more authors.
International Journal of Radiation Oncology Biology Physics | Year: 2011

Purpose: To evaluate the outcome, tolerance, and toxicity of stereotactic body radiotherapy, using image-guided robotic radiation delivery, for the treatment of patients with unresectable liver metastases. Methods and Material: Patients were treated with real-time respiratory tracking between July 2007 and April 2009. Their records were retrospectively reviewed. Metastases from colorectal carcinoma and other primaries were not necessarily confined to liver. Toxicity was evaluated using National Cancer Institute Common Criteria for Adverse Events version 3.0. Results: Forty-two patients with 62 metastases were treated with two dose levels of 40 Gy in four Dose per Fraction (23) and 45 Gy in three Dose per Fraction (13). Median follow-up was 14.3 months (range, 3-23 months). Actuarial local control for 1 and 2 years was 90% and 86%, respectively. At last follow-up, 41 (66%) complete responses and eight (13%) partial responses were observed. Five lesions were stable. Nine lesions (13%) were locally progressed. Overall survival was 94% at 1 year and 48% at 2 years. The most common toxicity was Grade 1 or 2 nausea. One patient experienced Grade 3 epidermitis. The dose level did not significantly contribute to the outcome, toxicity, or survival. Conclusion: Image-guided robotic stereotactic body radiation therapy is feasible, safe, and effective, with encouraging local control. It provides a strong alternative for patients who cannot undergo surgery. © 2011 Elsevier Inc. Source


Antoni D.,Departement University Of Radiotherapie | Antoni D.,University of Strasbourg | Mornex F.,University of Lyon | Mornex F.,University Claude Bernard Lyon 1
Current Opinion in Oncology | Year: 2016

Purpose of review The treatment of locally advanced nonsmall cell lung cancer (NSCLC) is becoming a significant challenge because of a growing proportion of patients with unresectable or potentially eligible for surgery after a multimodality treatment, stage II to III disease. Despite a multimodality approach consisting in concurrent chemoradiotherapy, the prognosis remains poor. Recent findings Different strategies, including induction and consolidation chemotherapy, chemotherapy regimens, fractionation and radiation doses have been evaluated in phase II and III trials, as well as new therapeutic approaches such as immunotherapy. For patients with resectable stage III disease the optimal strategy remains unclear. The American Society for Radiation and Clinical Oncology and the European Society for Medical Oncology published recent guidelines in 2015. Summary Concurrent chemoradiotherapy improves overall survival compared with sequential chemotherapy followed by radiation. Adding induction or consolidation chemotherapy to chemoradiotherapy does not appear to improve the outcome. Chemotherapy based on cisplatin combined with radiation is recommended in stage III NSCLC. The standard dose and fractionation of radiotherapy are 60Gy, one daily fraction of 2Gy over 6 weeks. Targeted therapies and immunotherapy may improve the management of locally advanced NSCLC in the future. © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved. Source


Dupuis O.,Center Jean Bernard | Ganem G.,Center Jean Bernard | Bera G.,Center Henry plan | Pointreau Y.,Center Henry plan | And 4 more authors.
Cancer/Radiotherapie | Year: 2010

Esophageal cancers are highly malignant tumours with often a poor pronostic, except for minimal lesions treated with surgery. Radiation therapy, or combined radiation and chemotherapy is the most used therapeutic modality, alone or before oesophagectomy. The delineation of target volumes is now more accurate owing the possibility to use routinely the new imaging techniques (mainly PET). The aim of this work is to precise the radio-anatomical particularities, the pattern of spread of esophageal cancer and the principles of 3D conformal radiotherapy illustrated with a clinical case. © 2010 Elsevier Masson SAS. Source

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