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Fannang S.V.,Departement Of Chimie Organique Of Luniversite Of Yaounde 1 | Kuete V.,University of Dschang | Djama C.M.,Departement Of Chimie Organique Of Luniversite Of Yaounde 1 | Dongfack M.D.J.,Departement Of Chimie Organique Of Luniversite Of Yaounde 1 | And 6 more authors.
Chinese Chemical Letters | Year: 2011

A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22- trione, as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch. (Euphorbiaceae). Their structures were established on the basis of spectroscopic methods. The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active. © 2010 Published by Elsevier B.V. on behalf of Chinese Chemical Society.


Dongfack M.D.J.,Departement Of Chimie Organique Of Luniversite Of Yaounde 1 | Dongfack M.D.J.,University of Paris Descartes | Lallemand M.-C.,University of Paris Descartes | Kuete V.,University of Dschang | And 5 more authors.
Chemical and Pharmaceutical Bulletin | Year: 2012

From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′- dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(-) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 μg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 μg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii. © 2012 The Pharmaceutical Society of Japan.

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