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Kalmar, Sweden

Loof-Johanson M.,Linkoping University | Brudin L.,Linkoping University | Sundquist M.,Dep. of Surgery | Thorstenson S.,Dep. of Pathology and Cytology | Rudebeck C.E.,University of Tromso

Background: Several studies suggest that total breastfeeding time reduces breast cancer risk. The underlying mechanisms are unclear. Whether breastfeeding also affects the prognosis is not yet investigated. A number of tumour characteristics, i.e. histological type of cancer, grade, tumour size, Nottingham prognostic index, vascular invasion and DNA-ploidy, have been demonstrated to be of prognostic value. Methods: We have searched for a possible link between these prognostic markers and breastfeeding time, age at first child and number of children. 250 women treated for breast cancer have answered a questionnaire. Results: No significant interactions were found possibly with one exception, LVI vs. age at first child. We found, significant correlations between lobular cancer, and thereby also DNA-ploidy, and age at first childbirth. Conclusions: We have found that lobular cancer (and thereby also diploid tumours) are connected, independently, to age at first childbirth and possibly also to number of children but no other correlations between reproductive data, breastfeeding included, and prognostic markers used in this study were found. © 2010. Source

Van Wely B.J.,Radboud University Nijmegen | Van Den Wildenberg F.J.H.,Dep. of Surgery | Gobardhan P.,Apmhia Medical Center | Van Dalen T.,Dep. of Surgery | And 10 more authors.
European Journal of Surgical Oncology

Introduction: The objective of this study was to conduct a multicentre data analysis to identify prognostic factors for developing an axillary recurrence (AR) after negative sentinel lymph node biopsy (SLNB) in a large cohort of breast cancer patients with long follow-up. Patients and methods: The prospective databases from different hospitals of clinically node negative breast cancer patients operated on between, 2000 and 2002 were analyzed. SLNB was performed and pathological analysis done by local pathologists according to national guidelines. Adjuvant treatment was given according to contemporary guidelines. Multivariate analysis was performed using all available variables, a p-value of <0,05 was considered to be significant. Results: A total of 929 patients who did not undergo axillary lymph node dissection were identified. After a median follow up of 77 (range 1-106) months, fifteen patients developed an isolated AR (AR rate 1,6%). Multivariate analysis showed that young age (p = 0.007) and the absence of radiotherapy (p = 0.010) significantly increased the risk of developing an AR. Distant metastasis free survival (DMFS) was significantly worse for patients with an AR compared to all other breast cancer patients (p < 0,0001). Conclusion: Even after long-term follow up, the risk of developing an AR after a negative SLN in breast cancer is low. Young age and absence of radiation therapy are highly significant factors for developing an axillary recurrence. DMFS is worse for AR patients compared to patients initially diagnosed with N0 or N1 disease. © 2012 Elsevier Ltd. All rights reserved. Source

Kubo N.,Dep. of Surgery | Takeuchi N.,Dep. of Surgery | Nakayama A.,Dep. of Surgery | Ogiwara H.,Dep. of Surgery | And 3 more authors.
Japanese Journal of Cancer and Chemotherapy

A 58-year-old man with severe back pain caused by multiple vertebral metastases developed disseminated intravascular coagulation (DIC). We adopted palliative radiotherapy (8 Gy/1 day) for palliation of his back pain as initial treatment. Afterwards, we started sequential chemotherapy consisting of methotrexate (MTX) and 5-fluorouracil (5-FU). After two courses, DIC was resolved, and the patient was discharged in fair condition after five more courses of MTX and 5-FU therapy. Source

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