Denka Seiken Co.

Gosen, Japan

Denka Seiken Co.

Gosen, Japan

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An object of the present invention is to provide a method for increasing the sensitivity of an immunoassay system. In order to achieve the object, the present inventors have discovered that the sensitivity of an immunoassay system can be increased by pretreating urine and thus have completed the present invention.


Patent
Niigata University, Juntendo Educational Foundation and Denka Seiken Co. | Date: 2017-01-09

Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.


Patent
Niigata University, Juntendo Educational Foundation and Denka Seiken Co. | Date: 2017-01-09

Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.


Patent
Denka Seiken Co. | Date: 2017-08-02

A specimen extraction kit includes a flexible tubular container (10) configured to contain an extraction liquid, two holding portions (21) opposed to each other and arranged at opposite sides of the tubular container (10), a coupling portion (25) that couples the opposing holding portions (21), and a bending rib (23) arranged on each of the opposing holding portions (21) and configured to bend the tubular container (10) and an extraction subject (EM).


The present invention intends to provide an immunochromatographic test piece that makes it possible to achieve both highly sensitive detection of a substance to be detected and a simple test piece structure, which are usually difficult to be made compatible with each other. The immunochromatographic test piece is an immunochromatographic test piece comprising a membrane on which a capture substance being a ligand that bonds to a substance to be detected is immobilized, wherein insoluble carrier particles to which a ligand that bonds to the substance to be detected is bound are used and accumulated by being captured with the capture substance immobilized on the membrane, the membrane is irradiated with light to detect light emitted from a portion where the insoluble carrier particles are accumulated or light emitted from a portion surrounding and other than the portion where the insoluble carrier particles are accumulated, thereby measuring the substance to be detected, and a light-reflecting material is provided on a side of the membrane opposite to a side irradiated with light.


Patent
Denka Seiken Co. | Date: 2016-01-20

The present invention provides a test kit capable of rapid and highly sensitive detection. The test kit has a dropping region, which contains a portion onto which a liquid sample drops, a labeling substance holding region, at least a portion of which is connected downstream of the dropping region in the developing direction, and in which a labeling substance with a label immobilized on a substance that specifically binds with the substance to be detected is held, a developing region, which has a detection zone where the labeling substance is captured through the substance to be detected, at least a portion of which is connected downstream of the labeling substance holding region in the developing direction, and which allows the labeling substance having been made to flow out from the labeling substance holding region by the liquid sample, to develop into the detection zone, and retention inhibition means for inhibiting retention of the labeling substance in the labeling substance holding region when the liquid sample develops downstream.


Patent
Denka Seiken Co. | Date: 2016-07-20

A method for measuring influenza B virus by an immunoassay, which method enables specific detection of influenza B virus with a higher sensitivity than conventional methods, and a device or a kit therefor are disclosed. The method for measuring influenza B virus includes carrying out an immunoassay of influenza B virus by a sandwich method using two kinds of monoclonal antibodies each of which specifically reacts with the region of the 125th to 248th amino acids of matrix protein (M1) of influenza B virus, which two kinds of monoclonal antibodies are capable of binding to the region of the 125th to 248th amino acids of M1 at the same time, or antigen-binding fragments thereof.


Patent
Denka Seiken Co. | Date: 2016-04-13

A resin-impregnated boron nitride sintered body having superior thermal conductivity and superior strength, and a resin-impregnated boron nitride sintered body having superior conductivity and small anisotropy of thermal conductivity are provided. A resin-impregnated boron nitride sintered body, including: 30 to 90 volume% of a boron nitride sintered body having boron nitride particles bonded three-dimensionally; and 10 to 70 volume% of a resin; wherein the boron nitride sintered body has a porosity of 10 to 70%; the boron nitride particles of the boron nitride sintered body has an average long diameter of 10m or more; the boron nitride sintered body has a graphitization index by powder X-ray diffractometry is 4.0 or less; and an orientation degree of the boron nitride particles of the boron nitride sintered body by I.O.P is 0.01 to 0.05 or 20 to 100; and a resin-impregnated boron nitride sintered body, including: 30 to 90 volume% of a boron nitride sintered body having boron nitride particles bonded three-dimensionally; and 10 to 70 volume% of a resin; wherein: the boron nitride sintered body has a calcium content of 500 to 5000ppm; the boron nitride sintered body has a graphitization index by powder X-ray diffractometry of 0.8 to 4.0; the boron nitride sintered body comprises flake-like boron nitride particles having an average long diameter of 10m or more; and an orientation degree by I.O.P is 0.6 to 1.4; are provided.


The object of the present invention is to provide insoluble carrier particles used for high-sensitivity rapid immunoassay, which allow visual observation and high-sensitivity apparatus measurement. The insoluble carrier particles are visible colored insoluble carrier particles labeled with a fluorescent dye, which are used for immunoassay, wherein absorption of fluorescence by the visible colored insoluble carrier particles is low within a wavelength range of fluorescence emitted by the fluorescent dye.


Patent
Denka Seiken Co. | Date: 2016-07-20

A method for measuring influenza A virus by an immunoassay using an anti-influenza A virus monoclonal antibody which is highly reactive with a wide range of subtypes is disclosed. The method for measuring influenza A virus includes measuring influenza A virus by an immunoassay utilizing antigen-antibody reaction between a monoclonal antibody which specifically reacts with matrix protein (M1) of influenza A virus, or an antigen-binding fragment thereof, and influenza A virus in a sample.

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