Delta University for Science and Technology
Al Mansurah, Egypt
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Abbas H.A.M.A.H.,Zagazig University | Shaldam M.A.,Delta University for Science and Technology
African Health Sciences | Year: 2016

Background: Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. As a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria. Objectives: Investigation of the possible inhibition of quorum sensing-regulated virulence of Pseudomonas aeruginosa by glycer-yltrinitrate. Methods: The quorum sensing inhibiting activity of glyceryl trinitrate was assessed by inhibition of violacein production in Chromobacterium violaceum ATCC 12472. Its ability to inhibit pyocyanin, protease, biofilm and tolerance to oxidative stress was evaluated. Docking study was performed to study the interference of glyceryl trinitrate with the binding of autoinducers with LasR and rhlR receptors. Results: Glyceryl trinitrate exerted a significant biofilm inhibiting and eradicating activities. It decreased the production of quorum-sensing dependent violacein production. It significantly inhibited the production of pyocyanin and protease and diminished the tolerance against oxidative stress. Molecular docking study showed that glyceryl trinitrate interferes with the binding of autoinducers to their receptors. It could bind to Las Rand rhlr receptors with binding energy of -93.47 and -77.23, respectively. Conclusion: Glyceryl trinitrate can be an antivirulence agent in the treatment of Pseudomonas aeruginosa topical infections such as burn infections. © 2016, Makerere University, Medical School. All rights reserved.

Elsayed H.A.,Delta University for Science and Technology
Proceedings of 2014 9th IEEE International Conference on Computer Engineering and Systems, ICCES 2014 | Year: 2014

This paper presents a lossless audio coding using Burrows-Wheeler Transform (BWT) and a combination of a Move-To-Front coding (MTF) and Run Length Encoding (RLE). Audio signals used are assumed to be of floating point values. The BWT is applied to this floating point values to get the transformed coefficients; and then these resulting coefficients are converted using the Move-to-Front coding to coefficients can be better compressed and then these resulting coefficients are compressed using a combination of the Run Length Encoding, and entropy coding. Two entropy coding are used which are Arithmetic and Huffman coding. Simulation results show that the proposed lossless audio coding method outperforms other lossless audio coding methods; using only Burrows-Wheeler Transform method, using combined Burrows-Wheeler Transform and Move-to-Front coding method, and using combined Burrows-Wheeler Transform and Run Length Encoding method. © 2014 IEEE.

Al-Gayyar M.M.,Mansoura University | Elsherbiny N.M.,Delta University for Science and Technology
European Cytokine Network | Year: 2013

During the late 1970s, tumor necrosis factor alpha (TNF- α) was initially recognized as an endotoxininduced substance that was mainly produced by macrophages, and able to cause the lysis of certain tumor cells. Subsequent research demonstrated that TNF- α mediates a broad range of cellular activities, including proliferation, survival, differentiation and apoptosis. It is also considered to be essential for the induction and maintenance of the inflammatory immune responses. Meanwhile, visual impairment imposes a substantial disease burden on society. It is associated with both significant economic impact and reduction in quality of life. Visual impairment raises serious social challenges for both patients and their families, interfering with day-to-day life, and can limit employment possibilities.Manyof the most common, irreversible blinding pathologies involve neuronal loss fromthe retina, which is the light-sensing tissue of the eye. The retina, being part of the central nervous system, is unable to regenerate neurons lost to disease. Therefore, in the current review we will discuss the association between increased expression of TNF- α with neurodegenerative disorders, downstream cellular signaling mechanisms following interaction of TNF- α with its receptors, and the role of TNF- α as a possible target in the treatment of retinal neurodegenerative disorders.

Rezk M.R.,Cairo University | Badr K.A.,Delta University for Science and Technology | Badr K.A.,Advanced Research Center
Journal of Pharmaceutical and Biomedical Analysis | Year: 2014

A rapid, simple, sensitive and specific LC-MS/MS method has been developed and validated for the simultaneous estimation of amlodipine (AML), benazepril (BEN) and benazeprilat (BNT) using eplerenone and torsemide as internal standards (IS). The Xevo TQD LC-MS/MS was operated under the multiple-reaction monitoring mode using electrospray ionization. Sample preparation involves both extraction and precipitation techniques. The reconstituted samples were chromatographed on Acquity UPLC BEH C18 (50mm×2.1mm, 1.7μm) column by pumping 0.1% formic acid and acetonitrile in a gradient mode at a flow rate of 0.45ml/min. A detailed validation of the method was performed as per the FDA guidelines and the standard curves were found to be linear in the range of 0.1-5ng/ml for AML; 5-1200ng/ml for both BEN and BNT. The intra-day and inter-day precision and accuracy results were within the acceptable limits. A run time of 2.5min for each sample made it possible to analyze more than 300 human plasma samples per day. The developed assay method was successfully applied to a bioequivalence study in human volunteers. © 2014 Elsevier B.V.

Elsayed H.A.,Delta University for Science and Technology
2015 1st URSI Atlantic Radio Science Conference, URSI AT-RASC 2015 | Year: 2015

In this paper two new highly efficient hybrid lossless audio coding techniques based on the Burrows-Wheeler Transform (BWT) and the distance transform (DT) are presented. In both techniques, floating point samples of the audio signal are first applied to the BWT and the resulting coefficients are then applied to the DT to obtain more suitable coefficients for the next step of lossless compression. In the first proposed method, two entropy-based lossless compression methods are considered, namely Arithmetic coding and Huffman coding. On the other hand, in the second proposed method the entropy coding is first preceded by Run Length Encoding (RLE). © 2015 International Union of Radio Science (URSI).

Bakr R.,Delta University for Science and Technology
Geotechnical Engineering for Infrastructure and Development - Proceedings of the XVI European Conference on Soil Mechanics and Geotechnical Engineering, ECSMGE 2015 | Year: 2015

Sandy soils appear in many cases at relatively shallow depths underlain by clay soil having reasonable shear strength parameters. Meanwhile the continuous sandy or rocky layers exist very deep. In some regions located in the seismic belt the building codes restrict the building heights. Therefore, relatively low stresses are imposed on the soil. In such cases it is possible to terminate the pile foundation in the shallower sand layer. The long-term settlement representing both consolidation and creep phases should be carefully studied. This study focuses on the evaluation of the factors affecting the behavior of piles that rest in a sandy layer underlain by clay. Eighteen cases were investigated and included in this study. Effects of soil properties, pile length, pile diameter, as well as the distance between the pile toe and the top surface of the clay soil are investigated by field static load tests. The results showed that both the pile length and the pile diameter affect the pile behavior. The pile capacity increases significantly as any of both length and/or diameter of pile increases. The presence of a layer of soft soil underlying the pile bearing sandy layer does not affect the pile behavior as long as the frictional capacity is not reached. © The authors and ICE Publishing: All rights reserved, 2015.

Bakr R.,Delta University for Science and Technology
Geotechnical Special Publication | Year: 2016

The micropiles technique plays an important role in ground improvements. This technique can be used effectively in both new and existing buildings to treat foundation problems. Micropiles are often installed in restricted access and limited headroom situations. Micropiles are used in most soils to transfer the building loads to bearing layers. As a result of progress in drilling equipment it has become possible to design and execute micropiles with load capacities in excess of 300 tons and diameters in excess of 25 cm. This research focuses on the feasibility of using micropiles technique in the underpinning of foundations of existing buildings. A site located in Mansoura, Egypt was selected for this study where micropiles were installed to underpin the foundations of a building consisting of 13 floors. There was a significant bidirectional eccentricity caused a nonuniform stress distribution under the raft foundation. In presence of thick soft clay layers a large amount of differential settlement occurred followed by fast sudden tilting of the building. Micropiles were installed in a specific arrangement to transfer that part of the applied load to the sand layer and to reduce the applied stress on the upper clay layers. As a result the overall bearing capacity of both raft and micropiles was significantly increased to an extent enough to accommodate the applied loads safely. To evaluate the micropiles improvement technique both settlement and tilting results were routinely recorded for ten months after installation. The results showed that the settlement has completely stopped and the building has stabilized. © 2016 ASCE.

Sherif I.O.,Mansoura University | Al-Gayyar M.M.H.,Mansoura University | Al-Gayyar M.M.H.,Delta University for Science and Technology
European Cytokine Network | Year: 2013

Purpose: Sodium nitrite, a food additive that is used as a color fixative and preservative for meats and fish, has been reported to have adverse health effects due to increased oxidative stress that could be harmful to different organs including the liver. Meanwhile, silymarin protects against hepatotoxicity caused by a variety of agents, on account of its antioxidative and anti-inflammatory effects.We therefore examined the impact of dietary silymarin on sodium nitrite-induced liver damage in rats. Methods: Fifty adult male Sprague-Dawley rats received 80 mg/kg sodium nitrite in the presence or absence of silymarin (10 and 25 mg/kg). Hepatic proinflammatory cytokines (TNF-α and IL-1β), hepatic fibrosis marker (MCP-1 and TGF-β1), mitochondrial activity marker (cytochrome C oxidase) and c-reactive protein (CRP) levels were measured. Hepatic apoptosis was assessed through determination of caspase-3 activity and DNA fragmentation. Results:We found that oral sodium nitrite enhanced oxidative stress with subsequent increases in TNF-α (2-fold), IL-1β (4-fold), MCP-1 (4-fold), TGF-β1 (3-fold) and CRP (4-fold). In addition, sodium nitrite brings about reduced cytochrome C oxidase and enhanced caspase-3 activity and DNA fragmentation. Daily treatment with silymarin markedly ameliorated all these effects. Conclusions: Silymarin ameliorated the impairment of hepatic function in rats that had ingested sodium nitrite. Silymarn possesses antioxidant, anti-inflammatory, antifibrotic and anti-apoptotic effects.

Abdallah Y.M.,Delta University for Science and Technology
Journal of Molecular Liquids | Year: 2016

Inhibition influence of phenyl sulphonyl ethanone derivatives (PSED) on corrosion of aluminum in 0.5 M H2SO4 solutions were investigated by many techniques namely potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation (EFM) supplemented by studying the surface morphology using scanning electron microscope (SEM). Potentiodynamic polarization measurements showed that the investigated compounds act as mixed type inhibitors. The inhibition efficiency increases by increasing compounds concentration, but decreases by raising temperature. Electrochemical impedance spectroscopy was used to investigate the mechanism of corrosion inhibition. Electrochemical frequency modulation results indicates that each spectrum is a current response as a function of frequency. A kinetic model and the Langmuir adsorption isotherm well fit the experimental data. The scanning electron microscope results showed the formation of a protective film on the metal surface in the presence of investigated compounds. According to molecular dynamics simulations the investigated compounds have been simulated as adsorbate on Al (1 1 1) substrate and the adsorption energy have been identified o aluminum surface. Some quantum chemical parameters were calculated to improve further insight into the mechanism of inhibition of the corrosion process. © 2016 Elsevier B.V. All rights reserved.

El-Ashmawy N.E.,Tanta University | Khalil R.M.,Delta University for Science and Technology
Tumor Biology | Year: 2014

l-carnitine is an antioxidant and is found to be a protective agent against many diseases including cancer. This review illustrates the possible role of l-carnitine as an add-on therapy to breast cancer patients maintained on tamoxifen. The objectives of carnitine treatment are diverse: improving tamoxifen-related side effects, offering better cancer prognosis by reducing the risk of developing cancer recurrence or metastasis, and modulating the growth factors which may be, in part, a prospective illustration to overcome tamoxifen resistance. So, it could be recommended to supplement l-carnitine to breast cancer patients starting tamoxifen treatment. © 2013 International Society of Oncology and BioMarkers (ISOBM).

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