Delta University

Al Qanāţir al Khayrīyah, Egypt

Delta University

Al Qanāţir al Khayrīyah, Egypt
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El-Helby A.-G.A.,Al - Azhar University of Egypt | Ayyad R.R.A.,Al - Azhar University of Egypt | Ayyad R.R.A.,Delta University | El-Adl K.,Al - Azhar University of Egypt | Elwan A.,Al - Azhar University of Egypt
Medicinal Chemistry Research | Year: 2017

A new series of 4-acetyl-1-substituted-3,4-dihydroquinoxalin-2(1H)-ones (3–14) were designed and synthesized in order to evaluate their α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonism as a proposed mode of their anticonvulsant activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (infrared, 1H nuclear magnetic resonance (NMR), 13CNMR, and mass). The molecular design was performed for all synthesized compounds to predict their binding affinity towards AMPA-receptor in order to rationalize their anticonvulsant activity in a qualitative way and explain the possible interactions that might take place between the tested derivatives and AMPA receptor in comparing to compounds III and YM872 in order to obtain the anticonvulsant effect. The data obtained from the molecular modeling was strongly correlated with that obtained from the biological screening which revealed that; compounds 14b, 14a, and 13b showed the highest binding affinities toward AMPA-receptor and also showed the highest anticonvulsant activities against pentylenetetrazole-induced seizures in experimental mice. The relative potencies of these compounds were 1.89, 1.83, and 1.51 respectively, in comparing to diazepam. © 2017 Springer Science+Business Media, LLC


Khalil R.M.,Delta University | Khedr N.F.,Tanta University
NeuroSignals | Year: 2016

Background: Monosodium glutamate (MSG) is a flavor enhancer used in food industries. MSG is well documented to induce neurotoxicity. Curcumin (CUR) reportedly possesses benefcial effects against various neurotoxic insults. Hence, this present study has been designed to evaluate the neuroprotective effect of curcumin on MSG-induced neurotoxicity in rats. Methods: Thirty-two male Wister rats were divided into four groups (n=8): Control group, MSG group, CUR group and MSG + CUR group. CUR (Curcumin 150 mg/kg, orally) was given day after day for four weeks along with MSG (4 mg/kg, orally). After 4 weeks, rats were sacrifced and brain hippocampus was isolated immediately on ice. Inflammatory marker TNFα and acetylcholinesterase (AChE) activity (marker for cholinergic function) were estimated. Gene expressions of metabotropic glutamate receptor 5 (mGluR5) and N-methyl-D-aspartate receptor 2B (NMDA2B) along with glutamate concentration were assessed. Results: Treatment with CUR signifcantly attenuated AChE activity and TNFa in MSG-treated animals. The antiinflammatory properties of CUR may be responsible for this observed neuroprotective action. A possible role of CUR to attenuate both glutamate level and gene expression of NMDA2B and mGLUR5 in brain hippocampus was established when compared to MSG group. Conclusion: We concluded that CUR as flavor enhancer protects against MSG-induced neurotoxicity in rats. © 2016 The Author(s). Published by S. Karger AG, Basel.


Gaballah H.H.,Tanta University | Zakaria S.S.,Tanta University | Mwafy S.E.,University of Sfax | Tahoon N.M.,Tanta University | Ebeid A.M.,Delta University
Biomedicine and Pharmacotherapy | Year: 2017

Background The development of complementary treatment strategies that focuses on achieving a balance between adaptive and apoptotic unfolded protein response (UPR), enhancing endoplasmic reticulum (ER) homeostasis, and thus preserving β cell mass and function is particularly warranted. Aim This study was designed to investigate the effectiveness of the combined treatment by Quercetin (QUE) and Liraglutide (LIRA) in modulating hyperglycemia, insulin-insensitivity, UPR/ER stress markers, apoptosis, oxidative stress and inflammation using a high-fat diet/streptozotocin −induced type 2 diabetic rat model. Methods Sixty male albino rats were allocated into five equal groups: normal control, diabetic control, LIRA treated diabetic; QUE treated diabetic and combined treatment diabetic groups. Fasting glucose, insulin, CHOP, macrophage inflammatory protein −1 α (MIP-1α) and Bax, Bcl2 levels were estimated by ELISA; mRNA expression levels of the spliced X-box binding protein 1 (XBP1) were estimated using quantitative real-time RT-PCR, while MDA, advanced oxidation protein products, reduced glutathione levels and protein disulfide isomerase (PDI) activity were evaluated spectrophotometrically. Pancreatic tissues were also subjected to histopathological examination. Results The combined treatment with both LIRA and QUE causes significant improvements in all the studied parameters; including XBP1 splicing, CHOP, MIP-1α, Bax/Bcl2 ratio, PDI activity, as well as oxidative stress markers as compared to either treatment alone. It also attenuated pancreatic histopathological damage. In conclusion Our study nominates this combination to be used in T2DM to achieve adequate glycaemic control and to preserve optimal β cell function. © 2017


El-Helby A.-G.A.,Al - Azhar University of Egypt | Ayyad R.R.A.,Al - Azhar University of Egypt | Ayyad R.R.A.,Delta University | El-Adl K.,Al - Azhar University of Egypt | And 4 more authors.
Medicinal Chemistry Research | Year: 2016

A new series of 4-acetyl-1-substituted-3,4-dihydroquinoxalin-2(1H)-ones (2–13) were designed and synthesized in order to evaluate their AMPA-receptor antagonism as a potential mode of anticonvulsant activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1HNMR, 13CNMR and Mass). The molecular design was performed for all the synthesized compounds to predict their binding affinity to AMPA-receptor in order to rationalize their anticonvulsant activity in a qualitative way. The data obtained from the molecular modeling was strongly correlated with that obtained from the biological screening which revealed that; compounds 12b, 13, 12a and 7a showed the highest binding affinities toward AMPA-receptor and also showed the highest anticonvulsant activities against pentylenetetrazole -induced seizures in experimental mice. The relative potencies of these compounds were 1.66, 1.66, 1.61 and 0.82 respectively, in comparing to diazepam. © 2016 Springer Science+Business Media New York


Abou-El-Sherbini K.S.,National Research Center of Egypt | Kenawy I.M.M.,Mansoura University | Hafez M.A.H.,Mansoura University | Lotfy H.R.,Delta University | Abdelbary Z.M.E.A.,Mansoura University
Journal of Environmental Chemical Engineering | Year: 2015

The new CO3 2-/Cl- layered double hydroxides (LDHs) (Mg(3-3v)Zn3v)/(Al(1-w)Few) were synthesized and calcined at 450 °C (CLDH), where v and w = 0, 0.1, 0.2, and/or 1, as adsorbents to remove anionic hazards such as Isolan Dark Blue 2SGL-01 (IDB) and CrO4 2- from polluted wastewater. The products were characterized by powder X-ray diffractometry, Fourier transform infra-red spectra, thermogravimetric analysis, elemental analysis, scanning electron microscope, magnetic susceptibility and specific surface area measurements. The effect of composition of LDH's on their uptake capacities (qe) for IDB and chromate ions were studied. CLDH's were more effective in removing anionic hazards than LDH, in particular with IDB and for v and w = 0.1 and/or 0.2. High adsorption capacities were obtained up to 438 and 46.3 mg g-1 (30.1 and 15.7% of the theoretical capacities), for IDB and chromate, respectively. Fe-containing LDHs could be magnetically separated either as-synthesized or loaded. © 2015 Elsevier Ltd.


Khedr N.F.,Tanta University | Khalil R.M.,Delta University
Tumor Biology | Year: 2015

Doxorubicin (DOX) is widely used in cancer therapy of many carcinomas types. Unfortunately, DOX is not sufficiently effective in many cases, and increasing the dosage of it is limited due to its systemic toxicity. A citrus flavonoid hesperidin (HES) is proved to be potent antioxidant and protective agent against many diseases including cancer. In this context, the objective of this study was to examine effect of HES along with DOX on solid Ehrlich carcinoma (SEC) in mice. Forty male mice were divided into four equal groups (n = 10): control SEC, DOX, HES, and DOX + HES. HES (50 mg/kg body weight orally) was given day after day for 16 days along with DOX (4 mg/kg body weight i.p. injection) for 5 cycles every 4 days in ESC-inoculated mice. After 20 days, tumor volume, tumor weight, survival rate, tumor glutathione, nitric oxide content, and serum glutathione were determined. Tumor tissue was examined for histopathological and immunohistochemical study for p53 and VEGF. Tumor resistance for mdr1a gene was assessed in tumor tissue by RT-PCR. HES induced significant increase in tissue and serum glutathione with significant decrease in tumor volume and tumor weight. A possible role of HES to modulate gene expression of mdr1a in tumor tissue was established. In addition, HES alleviated the histopathological changes with significant decrease in p53 and VEGF expression. The use of HES as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors. © 2015, International Society of Oncology and BioMarkers (ISOBM).


PubMed | Tanta University and Delta University
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2015

Doxorubicin (DOX) is widely used in cancer therapy of many carcinomas types. Unfortunately, DOX is not sufficiently effective in many cases, and increasing the dosage of it is limited due to its systemic toxicity. A citrus flavonoid hesperidin (HES) is proved to be potent antioxidant and protective agent against many diseases including cancer. In this context, the objective of this study was to examine effect of HES along with DOX on solid Ehrlich carcinoma (SEC) in mice. Forty male mice were divided into four equal groups (n=10): control SEC, DOX, HES, and DOX+HES. HES (50 mg/kg body weight orally) was given day after day for 16 days along with DOX (4 mg/kg body weight i.p. injection) for 5 cycles every 4 days in ESC-inoculated mice. After 20 days, tumor volume, tumor weight, survival rate, tumor glutathione, nitric oxide content, and serum glutathione were determined. Tumor tissue was examined for histopathological and immunohistochemical study for p53 and VEGF. Tumor resistance for mdr1a gene was assessed in tumor tissue by RT-PCR. HES induced significant increase in tissue and serum glutathione with significant decrease in tumor volume and tumor weight. A possible role of HES to modulate gene expression of mdr1a in tumor tissue was established. In addition, HES alleviated the histopathological changes with significant decrease in p53 and VEGF expression. The use of HES as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.

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