Penna C.,DellUniversity Turin |
Penna C.,Instituto Nazionale Ricerche Cardiovascolari |
Tullio F.,DellUniversity Turin |
Moro F.,DellUniversity Turin |
And 6 more authors.
Basic Research in Cardiology | Year: 2010
Brief periods (a few seconds) of cyclic coronary occlusions applied early in reperfusion induce a cardioprotection against infarct size, called postconditioning (PostC) in which B2-bradykinin receptors play a pivotal role. Since angiotensin-converting enzyme (ACE) inhibitors reduce degradation of kinins, we studied the effects of PostC on infarct size and postischemic myocardial dysfunction in both normotensive (WKY) and spontaneously hypertensive rats (SHR) acutely or chronically treated with the ACE inhibitor Captopril. Isolated hearts from SHR and WKY rats were subjected to the following protocols: (a) ischemia for 30- and 120-min reperfusion (I/R); (b) I/ R + PostC protocol (5-cycles 10-s I/R); (c) pretreatment with Captopril for 4-weeks before to subject the hearts to I/ R with or without PostC maneuvers. Some SHR hearts were treated with Captopril during the 20- or 40-min early reperfusion with or without PostC maneuvers. Cardiac function was assessed in vivo with echocardiography. Left ventricular pressure and infarct size were measured ex vivo. Chronic Captopril significantly reduced left ventricular hypertrophy in SHR, and reduced infarct size in both WKY and SHR hearts. PostC maneuvers significantly reduced infarct size in WKY, but not in SHR hearts. Yet, PostC slightly improved postischemic systolic function in untreated SHR. Captopril given in reperfusion was unable to limit I/R injury in SHR hearts. Data show that PostC protection against infarct size is blunted in SHR and that PostC is unable to add its protective effect to those of chronic Captopril, which per se reduces cardiac hypertrophy and heart susceptibility to I/R insult.
Carpentieri I.,DellUniversity Turin |
Brunella V.,DellUniversity Turin |
Bracco P.,DellUniversity Turin |
Paganini M.C.,DellUniversity Turin |
And 4 more authors.
Polymer Degradation and Stability | Year: 2011
The radiation-induced oxidative degradation of polyethylenes (PEs) with different degrees of crystallinity was characterized after electron-beam irradiation and during storage at room temperature. UHMWPE, HDPE, LDPE, LLDPE and an ethylene-octene copolymer (Engage) were e-beam irradiated to 30 or 60 kGy in vacuum or in air and stored at room temperature in air. EPR spectroscopy was used to investigate macro-radicals produced during irradiation and their post-irradiation changes. FTIR spectroscopy was used to monitor changes in the polymer structure, induced by irradiation, and to follow post-irradiation oxidation. We found that the crystallinity and the size of the crystalline lamellae, in particular, play a major role on the post-irradiation effects. The low-crystallinity polyethylenes showed no oxidation or oxidation only to a small extent, even when irradiated and stored in air. On the contrary, development of post-irradiation oxidation was observed in HDPE and UHMWPE. We attribute these results to a different reactivity of the macro-alkyl radicals formed upon irradiation in the amorphous or in the crystalline phase. While the radicals formed in the amorphous phase decay in short time, the migration time of the radicals trapped in the crystalline phase to the amorphous one is a key factor, governing the oxidation process. © 2011 Elsevier Ltd. All rights reserved.
Trotta F.,dellUniversity Turin |
Mio S.C.,dellUniversity Turin |
Martina K.,dellUniversity Turin |
Drioli E.,CNR Institute on Membrane Technology
Asia-Pacific Journal of Chemical Engineering | Year: 2010
In this study is reported the synthetic procedure and the characterisation of novel phosphorus containing polyether ether ketone (PEEK-P). The new polymer was synthesized via direct polycondensation of 2,2- bis(3-diethylphosphono-4- hydroxyphenyl)-propane and 4,4′-difluorobenzophenone according to well known general procedure and was extensively characterized by using infrared spectroscopy (FT-IR), thermogravimetric analyses (TGA), viscosity measurements and †H-NMR analysis. The obtained polymer is soluble in some organic solvents and the solution of phosphonated polymer could be used to obtain membranes by using the phase inversion technique. © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.
Bruno R.,University of Pavia |
Cariti G.,dellUniversity Turin |
Nasta P.,University of Brescia |
Capetti A.,Infectious Diseases |
And 6 more authors.
Liver International | Year: 2015
Background & Aims: Hepatitis C virus (HCV) genotype 3 (G3) is common among HIV/HCV co-infected individuals and associated with moderate sustained virological response (SVR) rates with pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy, while G2 is less frequent and associated with higher SVR. To determine SVR and other response rates, identify SVR predictors and analyse differences between G2 and G3 with PEG-IFN/RBV in a large HIV/HCV G2/3 patient population. Methods: This subgroup analysis of the prospective, observational OPERA (Optimized Pegylated interferon Efficacy and anti-Retroviral Approach) study was conducted between 2005 and 2011 in Italy in PEG-IFN/RBV-naïve HIV/HCV patients. The primary efficacy endpoint was SVR rate (HCV RNA <50 IU/ml or undetectable 24 weeks after end-of-treatment). Results: Five hundred and fifty-six HCV G2/3 patients (G2 n = 60; G3 n = 496) were treated with PEG-IFN alfa-2a 180 μg/week or PEG-IFN alfa-2b 1.5 μg/kg, + RBV 13.6 ± 2.3 (mean ± SD) mg/kg/day for median 47 (26-54) weeks. SVR rates were 57.7%, 68.3% and 56.5% for G2/3, G2 and G3 respectively) and RVR rates were 53.2%, 57.1% and 45.8% respectively. Independent SVR predictors were undetectable baseline HIV RNA [adjusted odds ratio (AOR), 2.64; 95% CI: 1.523-4.565, P = 0.0005], age (AOR 0.95 per year; 95% CI: 0.908-0.994, P = 0.0258) and anti-HCV treatment duration (AOR 1.034 per week; 95% CI: 1.013-1.057, P = 0.0019). Conclusions: Undetectable HIV RNA, longer anti-HCV treatment adherence and younger age were independent SVR predictors in treatment-naïve HIV/HCV G2/3 patients receiving PEG-IFN/RBV. Suppressing HIV RNA replication before anti-HCV therapy and increasing adherence to PEG-IFN/RBV treatment SVR rates may improve SVR. © 2014 John Wiley & Sons A/S.
Tinto A.,University of Turin |
Rosato M.R.,CSAM ISEF |
Critelli M.,DellUniversity Turin |
Schlacht I.L.,TU Berlin |
And 2 more authors.
Proceedings of the International Astronautical Congress, IAC | Year: 2012
Rhythmic Gymnastics in Microgravity to Improve the Human Movement Space is the theme of a project we have attempted to develop with the students at the Motion Sciences School (SU1SM) of the University of Turin using cither the facilities offered by the space industry in Turin or 0g situations like parabolic flights. The immediate aspect of the proposal is to evaluate the differences in the perception of sound/rhythm and the effect on performance in gymnastics engagement on Earth and in microgravity, taking advantage of the opportunity to study this particular aspect of human movement and the feeling expressed by this Olympic sport. Gymnastics is an activity that is essentially "gravitation based". We present some physical training exercises aimed at orientation education in space as a function of microgravity. Three areas/sectors have been identified: on the ground, with tools, and in the water. Exercises in earthly conditions were presented in ten gym work sessions prepared in teamwork with the SUISM students. ©(2012) by the International Astronautieal Federation.
Baracco A.,DellUniversity Turin |
Perrelli F.,DellUniversity Turin |
Romano C.,DellUniversity Turin
Giornale Italiano di Medicina del Lavoro ed Ergonomia | Year: 2010
The Italian decree law 81/2008 mentions the application of ergonomic principles as a basic tool for the prevention. In this regulation we can not find the definition either of Ergonomics nor of the competences required for its correct application. The Authors consider that occupational physicians have a suitable competence and knowledge on the matter, thanks to their highly specialized training. Actually, the ergonomic doctrine shows up in the daily practice of occupational physicians, who regularly base their activity on the evaluation of the binomial "worker-task": in the management of fitness to work judgements they try to combine operating conditions with worker's psychophysical state, not confining themselves to a simple expression of a medico-legal certificate. However, the legislative references to specific regulations raise difficulties to occupational physicians in dealing with aspects such as gender, age, reference values and methodological choices. The Authors debate these difficulties in the application of rules. © PI-ME, Pavia 2010.
Barbero M.,DellUniversity Turin |
Cadamuro S.,DellUniversity Turin |
Dughera S.,DellUniversity Turin
Arkivoc | Year: 2012
O-Benzenedisulfonimide has been used to efficiently catalyse the reaction between 2-aminothiophenol, 2-aminophenol, o-phenylenediamine and various ortho esters (28 examples; average yield 90%) or aldehydes (17 examples; average yield 72%) giving the corresponding benzofused azoles in excellent yields. Reaction conditions were very simple. In addition, other carboxylic acid derivatives have been tested and gave good results. The catalyst was easily recovered and reused. © ARKAT-USA, Inc.
Trotta F.,DellUniversity Turin |
Drioli E.,DellUniversity Calabria |
Luda M.P.,DellUniversity Turin |
Musso S.,Polytechnic University of Turin |
And 2 more authors.
Journal of Applied Polymer Science | Year: 2010
The synthetic procedure and the characterization of the new amino derivatives of poly(oxa-p-phenylene-3,3-phtalido-p-phenylene-oxa-p-phenilene- oxy-phenylene) (PEEK-WC) with various average degrees of substitution, is reported. The amino PEEK-WC was extensively characterised by using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis, differential scanning calorimeter, scanning electron microscopy, Elemental analyses, NMR, and viscosity measurements. The amino PEEK-WC shows different solubility in some solvents in comparison with the parent polymer, good thermal stability and is able to form membrane by means of the phase inversion technique. Amino PEEK-WC results to be quite reactive and can lead to further modification. © 2010 Wiley Periodicals, Inc.
Prenesti E.,DellUniversity Turin |
Berto S.,DellUniversity Turin |
Toso S.,Castrol |
Daniele P.G.,DellUniversity Turin
The Scientific World Journal | Year: 2012
A chemical model of the acid-base properties is optimized for each white wine under study, together with the calculation of their ionic strength, taking into account the contributions of all significant ionic species (strong electrolytes and weak one sensitive to the chemical equilibria). Coupling the HPLC-IEC and HPLC-RP methods, we are able to quantify up to 12 carboxylic acids, the most relevant substances responsible of the acid-base equilibria of wine. The analytical concentration of carboxylic acids and of other acid-base active substances was used as input, with the total acidity, for the chemical modelling step of the study based on the contemporary treatment of overlapped protonation equilibria. New protonation constants were refined (L-lactic and succinic acids) with respect to our previous investigation on red wines. Attention was paid for mixed solvent (ethanol-water mixture), ionic strength, and temperature to ensure a thermodynamic level to the study. Validation of the chemical model optimized is achieved by way of conductometric measurements and using a synthetic wine especially adapted for testing. © 2012 Enrico Prenesti et al.
PubMed | dellUniversity Turin
Type: Comparative Study | Journal: Basic research in cardiology | Year: 2010
Brief periods (a few seconds) of cyclic coronary occlusions applied early in reperfusion induce a cardioprotection against infarct size, called postconditioning (PostC) in which B(2)-bradykinin receptors play a pivotal role. Since angiotensin-converting enzyme (ACE) inhibitors reduce degradation of kinins, we studied the effects of PostC on infarct size and postischemic myocardial dysfunction in both normotensive (WKY) and spontaneously hypertensive rats (SHR) acutely or chronically treated with the ACE inhibitor Captopril. Isolated hearts from SHR and WKY rats were subjected to the following protocols: (a) ischemia for 30- and 120-min reperfusion (I/R); (b) I/R + PostC protocol (5-cycles 10-s I/R); (c) pretreatment with Captopril for 4-weeks before to subject the hearts to I/R with or without PostC maneuvers. Some SHR hearts were treated with Captopril during the 20- or 40-min early reperfusion with or without PostC maneuvers. Cardiac function was assessed in vivo with echocardiography. Left ventricular pressure and infarct size were measured ex vivo. Chronic Captopril significantly reduced left ventricular hypertrophy in SHR, and reduced infarct size in both WKY and SHR hearts. PostC maneuvers significantly reduced infarct size in WKY, but not in SHR hearts. Yet, PostC slightly improved postischemic systolic function in untreated SHR. Captopril given in reperfusion was unable to limit I/R injury in SHR hearts. Data show that PostC protection against infarct size is blunted in SHR and that PostC is unable to add its protective effect to those of chronic Captopril, which per se reduces cardiac hypertrophy and heart susceptibility to I/R insult.