Bruno R.,University of Pavia |
Cariti G.,DellUniversity Turin |
Nasta P.,University of Brescia |
Capetti A.,Infectious Diseases |
And 6 more authors.
Liver International | Year: 2015
Background & Aims: Hepatitis C virus (HCV) genotype 3 (G3) is common among HIV/HCV co-infected individuals and associated with moderate sustained virological response (SVR) rates with pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy, while G2 is less frequent and associated with higher SVR. To determine SVR and other response rates, identify SVR predictors and analyse differences between G2 and G3 with PEG-IFN/RBV in a large HIV/HCV G2/3 patient population. Methods: This subgroup analysis of the prospective, observational OPERA (Optimized Pegylated interferon Efficacy and anti-Retroviral Approach) study was conducted between 2005 and 2011 in Italy in PEG-IFN/RBV-naïve HIV/HCV patients. The primary efficacy endpoint was SVR rate (HCV RNA <50 IU/ml or undetectable 24 weeks after end-of-treatment). Results: Five hundred and fifty-six HCV G2/3 patients (G2 n = 60; G3 n = 496) were treated with PEG-IFN alfa-2a 180 μg/week or PEG-IFN alfa-2b 1.5 μg/kg, + RBV 13.6 ± 2.3 (mean ± SD) mg/kg/day for median 47 (26-54) weeks. SVR rates were 57.7%, 68.3% and 56.5% for G2/3, G2 and G3 respectively) and RVR rates were 53.2%, 57.1% and 45.8% respectively. Independent SVR predictors were undetectable baseline HIV RNA [adjusted odds ratio (AOR), 2.64; 95% CI: 1.523-4.565, P = 0.0005], age (AOR 0.95 per year; 95% CI: 0.908-0.994, P = 0.0258) and anti-HCV treatment duration (AOR 1.034 per week; 95% CI: 1.013-1.057, P = 0.0019). Conclusions: Undetectable HIV RNA, longer anti-HCV treatment adherence and younger age were independent SVR predictors in treatment-naïve HIV/HCV G2/3 patients receiving PEG-IFN/RBV. Suppressing HIV RNA replication before anti-HCV therapy and increasing adherence to PEG-IFN/RBV treatment SVR rates may improve SVR. © 2014 John Wiley & Sons A/S.
Tinto A.,University of Turin |
Rosato M.R.,CSAM ISEF |
Critelli M.,DellUniversity Turin |
Schlacht I.L.,TU Berlin |
And 2 more authors.
Proceedings of the International Astronautical Congress, IAC | Year: 2012
Rhythmic Gymnastics in Microgravity to Improve the Human Movement Space is the theme of a project we have attempted to develop with the students at the Motion Sciences School (SU1SM) of the University of Turin using cither the facilities offered by the space industry in Turin or 0g situations like parabolic flights. The immediate aspect of the proposal is to evaluate the differences in the perception of sound/rhythm and the effect on performance in gymnastics engagement on Earth and in microgravity, taking advantage of the opportunity to study this particular aspect of human movement and the feeling expressed by this Olympic sport. Gymnastics is an activity that is essentially "gravitation based". We present some physical training exercises aimed at orientation education in space as a function of microgravity. Three areas/sectors have been identified: on the ground, with tools, and in the water. Exercises in earthly conditions were presented in ten gym work sessions prepared in teamwork with the SUISM students. ©(2012) by the International Astronautieal Federation.
Cirio R.,National Institute of Nuclear Physics, Italy |
Cirio R.,DellUniversity Turin |
Fausti F.,National Institute of Nuclear Physics, Italy |
Fausti F.,Polytechnic University of Turin |
And 13 more authors.
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2015
Abstract The development of the next generation of accelerators for charged particle radiotherapy aims to reduce dimensions and operational complexity of the machines by engineering pulsed beams accelerators. The drawback is the increased difficulty to monitor the beam delivery. Within each pulse, instantaneous currents larger by two to three orders of magnitude than present applications are expected, which would saturate the readout of the monitor chambers. In this paper, we report of a simple method to increase by almost two orders of magnitude the current range of an Application Specific Integrated Circuit chip previously developed by our group to read out monitor ionization chambers. © 2015 Elsevier B.V.
Trotta F.,DellUniversity Turin |
Drioli E.,DellUniversity Calabria |
Luda M.P.,DellUniversity Turin |
Musso S.,Polytechnic University of Turin |
And 2 more authors.
Journal of Applied Polymer Science | Year: 2010
The synthetic procedure and the characterization of the new amino derivatives of poly(oxa-p-phenylene-3,3-phtalido-p-phenylene-oxa-p-phenilene- oxy-phenylene) (PEEK-WC) with various average degrees of substitution, is reported. The amino PEEK-WC was extensively characterised by using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis, differential scanning calorimeter, scanning electron microscopy, Elemental analyses, NMR, and viscosity measurements. The amino PEEK-WC shows different solubility in some solvents in comparison with the parent polymer, good thermal stability and is able to form membrane by means of the phase inversion technique. Amino PEEK-WC results to be quite reactive and can lead to further modification. © 2010 Wiley Periodicals, Inc.
Trotta F.,DellUniversity Turin |
Mio S.C.,DellUniversity Turin |
Martina K.,DellUniversity Turin |
Drioli E.,CNR Institute on Membrane Technology
Asia-Pacific Journal of Chemical Engineering | Year: 2010
In this study is reported the synthetic procedure and the characterisation of novel phosphorus containing polyether ether ketone (PEEK-P). The new polymer was synthesized via direct polycondensation of 2,2- bis(3-diethylphosphono-4- hydroxyphenyl)-propane and 4,4′-difluorobenzophenone according to well known general procedure and was extensively characterized by using infrared spectroscopy (FT-IR), thermogravimetric analyses (TGA), viscosity measurements and †H-NMR analysis. The obtained polymer is soluble in some organic solvents and the solution of phosphonated polymer could be used to obtain membranes by using the phase inversion technique. © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.