Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 530.44K | Year: 2016
DESCRIPTION provided by applicant Although there are numerous scientific studies in the literature that show impairments in olfaction often occur early in the onset of Alzheimerandapos s Disease AD there is still concern pertaining to the specificity of measures of olfactory dysfunction when used as a predictor of AD For this and other reasons there is no test based upon measures of olfactory function that has been cleared by the FDA for use as a screen for the disease Consequently the major goal of this application is comprised of two different but closely related components validating the OLFACT tm Test Battery TB as a sensitive early predictor of AD and gaining FDA clearance of the OLFACT tm TB for use as a screening test in the assessment of AD To achieve this goal two specific projects are proposed The first is to demonstrate that impairments in olfactory function predict onset of AD To accomplish this in Phase I an automated test of olfactory function the OLFACT tm TB will be developed and used to measure olfactory function in participants of the Rush University Medical Center Memory and Aging Project a longitudinal cohort in which over participants are being evaluated for the development of MCI and AD Participants in these studies are extensively evaluated on an annual basis with batteries of neuropsychological tests neurological exams and clinical assessments Using logistic regression this comprehensive data set will be used in conjunction with neuropathologic data the andquot gold standardandquot for diagnosing AD to be collected during Phase II to determine the predictive utility of olfactory function as a screening test for AD The exhaustive nature of this data set will allow other causes of olfactory dysfunction as well as other cause of dementia to be documented and controlled for Also in Phase II in a second project at Massachusetts General Hospital approximately subjects will be recruited who have already been extensively evaluated for AD and in addition many have also received both volumetric MRIandapos s and amyloid PET These subjects will be administered the OLFACT tm TB during the course of the project to evaluate how well these other biomarkers compare to measures of olfactory function as a predictor of AD These combined data sets will form the basis of the second component a Premarket Approval PMA application to the FDA to obtain clearance for the OLFACT tm TB as a screening test for AD The availability of a FDA cleared test which was valid noninvasive inexpensive and an early predictor of AD would be of immense value not only in the diagnosis of AD in preclinical stages but also as a way to reduce costs in the recruitment of affected individuals for clinical trials The test could also prove to e useful in the assessment of the efficacy of potential drug therapies or other therapeutic interventions when measured over time PUBLIC HEALTH RELEVANCE Alzheimerandapos s disease AD is the leading cause of dementia in old age with to million Americans currently affected and sharp increases in those numbers are expected by mid century with the aging of the U S population Impairments in the sense of smell are one of the earliest indicators associated with the development of AD This proposal will measure olfactory function in two longitudinal studies of AD in order to establish the relationship between loss of sense of smell and AD determine the relationship between measures of olfactory functions and other biomarkers and seek FDA clearance of the OLFACT tm Test Battery for use as a screening test in the assessment of AD This would be the first olfactory test cleared by the FDA for this purpose and would provide both clinicians and researchers a powerful tool in the fight against this disease
Agency: Department of Defense | Branch: Air Force | Program: SBIR | Phase: Phase II | Award Amount: 750.00K | Year: 2015
ABSTRACT: SpaceWorks Enterprises, Inc. (SEI) believes that industry demand exists for a new robust and modern trajectory simulation program suitable for use in design studies up through Preliminary Design Reviews (PDR). This proposal seeks to further develop a trajectory tool that is flexible enough to support a wide variety of space transportation concepts and launch platforms. The tool, called QuickShot, will offer a paradigm shift for engineers that switches the focus away from simply trying to get a trajectory simulation tool to run properly and towards constructive and insightful assessments based on results. BENEFIT: The customer base for the software is envisioned to range from government officials wanting to assess new design concepts (e.g. DoD, NASA, FAA) to the small launch vehicle/responsive space access community.
Della Enterprises, Inc. | Date: 2016-01-14
There is provided a system and method for communicating with a first peripheral device, of a plurality of peripheral devices, using a touch-sensitive system that has a processor and a touch surface. According to an exemplary embodiment, a method includes detecting, using the processor, a plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method further includes identifying, using the processor, the first peripheral device based on the plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method additionally includes communicating data, using the processor, to a receptive circuit of the first peripheral device in response to the identifying of the first peripheral device.
Della Enterprises, Inc. | Date: 2015-01-27
A method and apparatus for synchronizing multiple transmitters is disclosed. A global time reference is used to synchronize the arrival of data from a plurality of secondary transmitters in a receiver station. In one embodiment, the global time reference is provided by a GPS satellite, and may also be used to synchronize the carriers of the signals received at the receiver station from each of the plurality of transmitters. In one embodiment, a pilot signal used for ATSC applications is added by the secondary transmitters.
Della Enterprises, Inc. | Date: 2015-06-16
An apparatus creating a flickering flame effect. The apparatus includes a housing with an interior space with first and second stages. A drive mechanism generates a time varying electromagnetic field extending into the first stage. A first pendulum member is pivotally mounted in the interior space of the first stage and includes first and second magnets on first and second ends, with the first end proximate to the drive mechanism such that the first magnet interacts with the varying electromagnetic field to cause movement of the pendulum member. The apparatus includes a second pendulum member pivotally mounted in the second stage with a magnet on a first end proximate to the second end of the first pendulum member. A flame silhouette element extends from the second pendulum member, and a light source transmits light onto the flame silhouette, which is moving due to the magnetic coupling of the pendulum members.