Defence Research Development and Establishment

Gwalior, India

Defence Research Development and Establishment

Gwalior, India
SEARCH FILTERS
Time filter
Source Type

Upmanyu N.,Dr Hari Singh Gour University | Kumar S.,Defence Research Development and Establishment | Kharya M.-D.,Dr Hari Singh Gour University | Shah K.,GLA Institute of Pharmaceutical Research | Mishra P.,GLA Institute of Pharmaceutical Research
Acta Poloniae Pharmaceutica - Drug Research | Year: 2011

Triazoles with different substituent groups are found to possess diverse applications in the field of medicine and industry. A series of 4-(substituted ethanoyl)amino-3-mercapto-5-(4-nitro)phenyl-1,2,4-triazoles (NU-1 to NU-15) were synthesized as novel antimicrobial agents starting from 4-nitrobenzoic acid. The chemical structures of these newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, FAB+-MS spectral data and elemental analysis. Their antimicrobial activities against Staphylococcus aureus (ATCC-25923), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-8739), Bacillus substilis (ATCC-6633), Candida albicans (MTCC-227), Aspergillus niger (MTCC-3323) and Fusarium oxysporum (MTCC-2087) were investigated.


Upmanyu N.,Dr Hari Singh Gour University | Kumar S.,Defence Research Development and Establishment | Shah K.,GLA Institute of Pharmaceutical Research | Mishra P.,GLA Institute of Pharmaceutical Research
Medicinal Chemistry Research | Year: 2012

Triazoles and its derivatives are found to possess diverse applications in the field of medicine and industry. A series of novel 1,2,4-triazole derivatives have been synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The chemical structures of these newly synthesized compounds were elucidated by Fourier transform infrared spectroscopy (FTIR), 1H NMR, 13C NMR, FAB?-MS spectral data, and elemental analysis. Their antimicrobial activities were investigated against four bacterial strains S. aureus (ATCC-25923), P. aeruginosa (ATCC-27853), E. coli (ATCC-8739), B. subtilis (ATCC-6633) and three fungal strains C. albicans (MTCC-227), A. niger (MTCC-3323), and F. oxysporum (MTCC-2087). Preliminary results indicate that some of them exhibit promising activities and deserve further consideration. © Springer Science+Business Media, LLC 2011.


Upmanyu N.,Dr Hari Singh Gour University | Kumar S.,Defence Research Development and Establishment | Shah K.,GLA Institute of Pharmaceutical Research | Mishra P.,GLA Institute of Pharmaceutical Research
Dhaka University Journal of Pharmaceutical Sciences | Year: 2012

Triazoles and triazoles with different substituent groups are found to possess diverse application in the field of medicine and industry. A series of 4-(substituted) ethanoylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4- triazoles were synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The chemical structures of these newly synthesized compounds were elucidated by 1R, 1H NMR, 13C NMR, FAB+-mass spectral data and elemental analyses. The antimicrobial activity of title compounds were examined against two gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), two gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Fusarium oxysporum) using disc diffusion method. Some of the compounds bearing methoxy group exhibited moderate to good antibacterial and antifungal activities.

Loading Defence Research Development and Establishment collaborators
Loading Defence Research Development and Establishment collaborators