Deen Dayal Upadhyay Gorakhpur University

www.ddugu.in
Gorakhpur, India

Deen Dayal Upadhyay Gorakhpur University or simply Gorakhpur University is located in Gorakhpur, Uttar Pradesh. Wikipedia.

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Upadhyay R.K.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2016

Onion is a well-known traditional nutraceutical and medicinal plant that is cultivated and used around the world. Onions contain phenolics and flavonoids that have potential anti-inflammatory, anti-cholesterol, anticancer, and antioxidant properties. Onions contain 89% water, 1.5% protein, and vitamins B1, B2, and C, along with potassium and selenium. It also contains polysaccharides such as fructosans, saccharose, peptides, flavonoids (mostly quercetin), and essential oil. Onion contains numerous sulfur compounds including thiosulfinates and thiosulfonates; cepaenes; S-oxides; S, S-dioxides; mono, di, and tri-sulfides; and sulfoxides. Onion is highly nutritional and its dietary use improves digestion and mental health and lower down toxigenicity of oils. Onion has potential in treating cardiovascular disease, hyperglycemia, and stomach cancer. Onion contains an important antioxidative, i.e., quercetin that is derived from Allium cepa on aldehyde oxidase low-density lipoprotein which reduces hepatocytes apoptosis in streptozotocin-induced diabetic rat. Onion has great ethnomedicinal importance as native remedies used against diabetes, and related complications are from onion. A. cepa red and white varieties showed antimicrobial and antioxidant activities. These are used in traditional Indian spices and are of great health significance. These are curative for implications from and for food cultures for cardiovascular disease and provide longevity.


Upadhyay R.K.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2016

The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a main source of glucose. Mainly, herbal foods rich in flavanols and polyphenols show hypoglycemic effects and can be used in the prevention of diabetes-induced vascular dysfunctions. Antidiabetic plant natural products restore insulin level and increase utilization of external glucose. Herbal dietary supplementation having diverse antioxidants, fibers, minerals, and antiglycants show inhibitory activity against α-amylase and α-glycosidase can easily control carbohydrate metabolism in humans. No doubt plant origin natural products can be used as alternative medicine for treatment of diabetes, but they must need proper composition and formulation before being used.


Rai R.K.,Deen Dayal Upadhyay Gorakhpur University | Botet R.,University Paris - Sud
Monthly Notices of the Royal Astronomical Society | Year: 2017

In the infrared and visible wavelength ranges, the extinction cross-sections of small irregular particles are essentially proportional to the corresponding cross-sections for spheres of the same volume, which confirms a previous statement by Mathis. The situation differs for large disordered particles because of the contribution of large surface areas. The differences between irregular particles and homogeneous spheres of the same mass might depend on the material. For example, graphite particles are less sensitive to surface shapes than silicate particles. As a consequence, the successful fit of the average galactic extinction curve by an ensemble of graphite + silicate spherical particles, can also be replaced by a fit using an ensemble of irregular particles, including a smaller amount of silicate. Because the interstellar dust particles are expected to be generally of irregular shapes, the former fit with spherical particles could have overestimated the relative amount of silicate in the interstellar medium (ISM). In the same spirit, we discuss various interpretations of the remarkable stability of the 217.5-nm peak in the ISM extinction. © 2017 The Authors.


Upadhyay R.K.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2017

The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum Arabic is a water-soluble dietary fiber rich in Ca2+, Mg2+, and K+ that is used for the treatment of chronic kidney disease. It increases creatinine clearance, enhances renal excretion of antidiuretic hormone, Mg2+, and Ca2+, and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na+. Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broad-spectrum biological effectiveness.


Upadhyay R.K.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2017

The present review article explains medicinal and therapeutic uses of Tulsi plant in traditional medicine. Tulsi (Ocimum sanctum [OS] Linn.) is an aromatic plant belongs to family Lamiaceae. It is traditionally used for preparation of various Ayurvedic formulations for treatment of bronchitis, influenza, and asthma. Hot concoction of Tulsi leaves is usually provided for immediate relief in cold, sneezing nose, cough, malaria, and dengue. This article explains the biological effectiveness of OS against diabetes mellitus, hypertension, cancers, respiratory diseases, arthritis, various microbes, and parasites. Tulsi extracts and its various bio-organic constituents showed antioxidant activity, anti-atherogenic effect, anti-aging, immunomodulatory, anti-inflammatory, antistress, hepatoprotective, radioprotective, antihelmintic, repellent and larvicidal activity. Tulsi active ingredients showed anti-inflammatory properties and also play a role in modulation of both cellular and humeral immunity. Plant shows healing properties in hepatic injury and gastric ulcer. It relieves from stress, restore and improve body immunity and digestion. Ocimum basilicum L. contains (-)-linalool, eugenol and methyl chavicol, methyl chavicol (93.0%), gamma-caryophyllene as major constituents. Minor oil constituents are (+)-delta-cadinene, 3-carene, alpha-humulene, citral, and (-)-trans-caryophyllene. Tulsi oil contains high alpha-linolenic acid contents mainly eicosanoid precursor polyunsaturated fatty acids which are anti-inflammatory in nature. Tulsi also contains camphor, caryophyllene oxide, cineole, methyleugenol, limonene, myrcene, and thymol, which are known insect repellents. Its essential oil (EO) can be used to abate the growth of mosquitoes and control malaria. It is a good repellant and can be used for deterring flies, mosquitoes and insects. No doubt Tulsi plant is a good source of natural products mainly phyto-constituents and EO which can be used as alternative medicine for the treatment of various ailments and human health problems but proper composition and appropriate formulation is required before being used.


Upadhyay R.K.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2016

Garlic (Allium sativum) holds a unique therapeutic potential as it inhibits invasion of carcinoma, provides cardiovascular protection, lowering of cholesterol, blood pressure, anti-platelet activities, and thromboxane formation. It provides protection against atherosclerosis and associated disorders and helps to decrease serum levels of glucose, insulin, triglycerides, and uric acid, as well as insulin resistance, and reduces cytokine levels. It shows hypolipidemic, anti-platelet, and procirculatory effects, and antimutagenic and antiproliferative properties. It prevents cold and flu symptoms through immune enhancement and exhibits anticancer and chemopreventive activities. The main active component of garlic is alliin (S-allyl cysteine sulfoxide), a potent antioxidant which shows cardioprotective and neuroprotective actions. Diallyl trisulfide, major garlic derivatives, could inhibit the cell proliferation by triggering either cell cycle arrest or apoptosis in a variety of cancer cells. Organosulfur compounds from garlic inhibit the growth of transplanted as well as spontaneous cancers in preclinical animal models without any adverse side effects. Garlic is a good source of anti-invasive, antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, hepatoprotective, antimicrobial, apoptotic, cardioprotective, antidiabetic agents and shows insecticidal effects against lepidopteran, coleopteran, dipteran and homopteran insect pests. Hence, its constituents could be used to develop alternatives to conventional insecticides for control of serious fruit and vegetable pests. Garlic herbal preparations can reduce non-target exposure to hazardous insecticides and curb resistance development in insects. No doubt garlic based different ailments and concoctions can be used to alleviate a variety of health problems. Its various supplements contain a different concentration of organosulfur compounds are available commercially in market.


Upadhyay R.,Deen Dayal Upadhyay Gorakhpur University
International Journal of Green Pharmacy | Year: 2015

Cleome viscosa is an indigenous medicinal plant that shows large seasonal biodiversity in North-Western states of India. It is a common weed mainly found in crop fields, in waste lands, wet and grassy places all over the plains of India. Plant bears yellow flowers and long slender pods containing seeds that resemble those of mustard with strong penetrating odor in rainy and post rainy season. Seeds are oil producing and are used for making cattle cake. C. viscosa leaves and young shoots are used to cook like a vegetable, which is having sharp mustard-like flavor. Fatty oils of the seeds of C. viscosa contain major fatty acids, as methyl esters, of the oils mainly palmitic acid (10.2-13.4%), stearic acid (7.2-10.2%), oleic acid (16.9-27.1%) and linoleic acid (47.0-61.1%). Oil is rich in unsaturated fatty acids and nutrients, especially Vitamins A and C, minerals calcium and iron and protein. Plant also contains free gallic acid, gallotannins, iridoid, saponins and terpinoid polyphenolic compounds, which are well-known antioxidizing properties. Its oil is very similar in fatty acid composition to the nonedible oils of rubber, jatropha, soybean, safflower, linseed and rapeseed edible oils. Due to the presence of oils, plant can be used as a good source of green biodiesel. In the present review article, both pharmaceuticals and insecticidal properties of C. viscosae have been described in detail with special emphasis on its commercial use for production of non edible oil that can be used as biodiesel. Plant grows in tropical and subtropical climatic conditions.


Singh R.S.,Deen Dayal Upadhyay Gorakhpur University | Prakash H.,Allahabad University
Annals of Physics | Year: 2013

Polarization of light signifies transversal, anisotropic and asymmetrical statistical properties of electromagnetic radiation about the direction of propagation. Traditionally, optical-polarization is characterized by Stokes' theory susceptible to be insufficient in assessing the polarization structure of optical quantum fields and, also, does not decipher the twin characteristic polarization parameters ('ratio of real amplitudes and difference in phases'). An alternative way, in the spirit of classical description of optical-polarization, is introduced which can be generalized to deal higher-order polarization of quantum light, particularly, prepared in non-Gaussian Schrodinger Cat or Cat-like states and entangled bi-modal coherent states. On account of pseudo mono-modal or multi-modal nature of such optical quantum field, higher-order polarization is seen to be highly sensitive to the basis of description. © 2013 Elsevier Inc.


Kant Upadhyay R.,Deen Dayal Upadhyay Gorakhpur University
BioMed Research International | Year: 2013

JE is a flavivirus generated dreadful CNS disease which causes high mortality in various pediatric groups. JE disease is currently diagnosed by measuring the level of viral antigens and virus neutralization IgM antibodies in blood serum and CSF by ELISA. However, it is not possible to measure various disease-identifying molecules, structural and molecular changes occurred in tissues, and cells by using such routine methods. However, few important biomarkers such as cerebrospinal fluid, plasma, neuro-imaging, brain mapping, immunotyping, expression of nonstructural viral proteins, systematic mRNA profiling, DNA and protein microarrays, active caspase-3 activity, reactive oxygen species and reactive nitrogen species, levels of stress-associated signaling molecules, and proinflammatory cytokines could be used to confirm the disease at an earlier stage. These biomarkers may also help to diagnose mutant based environment specific alterations in JEV genotypes causing high pathogenesis and have immense future applications in diagnostics. There is an utmost need for the development of new more authentic, appropriate, and reliable physiological, immunological, biochemical, biophysical, molecular, and therapeutic biomarkers to confirm the disease well in time to start the clinical aid to the patients. Hence, the present review aims to discuss new emerging biomarkers that could facilitate more authentic and fast diagnosis of JE disease and its related disorders in the future. © 2013 Ravi Kant Upadhyay.


Singh H.J.,Deen Dayal Upadhyay Gorakhpur University | Upadhyay M.K.,Deen Dayal Upadhyay Gorakhpur University
Journal of Energetic Materials | Year: 2013

Structure optimization and frequency calculation of six nitro derivatives of 1,3,5-triazepine were performed using a MP2(FULL)/6-311G(d,p) method. In order to obtain reliable energy data, single-point energy and subsequently thermodynamic properties of the species considered were calculated at a fairly high level of theory, CCSD(T)/6-311G(d,p). Solid-phase heats of formation and crystal density were determined using an electrostatic potential (ESP) method utilizing wave function analysis-surface analysis suite (WFA-SAS) code. The result shows that all nitro derivatives possess high positive heats of formation that increase with an increase in the number of nitro groups attached to the ring moiety. The crystal density was found to be in the range of 1.67-1.90 g/cm3. Detonation properties of the compounds were estimated using the Kamlet-Jacobs equation. The results showed that detonation velocity (D) and detonation pressure (P) increased with an increase in the number of nitro groups attached at the ring moiety. It was found that all six nitro derivatives of the title compound had better or comparable performance characteristics than the most widely used commercial explosives, such as TNT, research and development explosives (RDX), and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX). The trinitro derivative (1,3,5-trinitro-1,3,5-triazepine, F) yielded detonation pressure (P) and detonation velocity (D) of 45.5 GPa and 9.23 km/s, respectively, at a loading density of 1.90 g/cm3, which are superior to the most powerful available explosive HMX (P = 39.00 GPa and D = 9.11 km/s). The results obtained during the present study show that the title compounds can be used as promising futuristic high-energy-density materials (HEDMs). © 2013 Copyright Taylor and Francis Group, LLC.

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