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Baden, Switzerland

Donath T.,DECTRIS Ltd. | Rissi M.,DECTRIS Ltd. | Billich H.,Paul Scherrer Institute
Synchrotron Radiation News | Year: 2013

A two-day workshop on beamline integration and data formatting (HDF5/NeXus) of the EIGER detector was held in Baden, Switzerland, January 24-25, 2013. Its aim was to discuss the technical challenges inherent with the next generation of high-frame-rate, high-resolution X-ray imaging detectors, and specifically with the EIGER detector. EIGER is a photon-counting hybrid pixel detector developed at the Paul Scherrer Institute (PSI) and DECTRIS Ltd. With even higher spatial resolution and frame rates than its predecessor, the PILATUS detector, it will be able to continuously produce up to 3000 images per second. The corresponding extreme data rates generated by this and future detectors present a significant challenge for beamline integration of the detectors, for data handling by the users, and for data processing software. Efficient data flow, storage, and processing must be achieved to handle the huge data sets that will be produced in seconds by these devices. © 2013 Copyright Taylor and Francis Group, LLC. Source

Waltersperger S.,Paul Scherrer Institute | Olieric V.,Paul Scherrer Institute | Pradervand C.,Paul Scherrer Institute | Glettig W.,Center Suisse dElectronique et Microtechnique | And 9 more authors.
Journal of Synchrotron Radiation | Year: 2015

The Parallel Robotics Inspired Goniometer (PRIGo) is a novel compact and high-precision goniometer providing an alternative to (mini-)kappa, traditional three-circle goniometers and Eulerian cradles used for sample reorientation in macromolecular crystallography. Based on a combination of serial and parallel kinematics, PRIGo emulates an arc. It is mounted on an air-bearing stage for rotation around ω and consists of four linear positioners working synchronously to achieve x, y, z translations and χ rotation (0-90°), followed by a φ stage (0-360°) for rotation around the sample holder axis. Owing to the use of piezo linear positioners and active correction, PRIGo features spheres of confusion of <1 μm, <7 μm and <10 μm for ω, χ and φ, respectively, and is therefore very well suited for micro-crystallography. PRIGo enables optimal strategies for both native and experimental phasing crystallographic data collection. Herein, PRIGo hardware and software, its calibration, as well as applications in macromolecular crystallography are described. © 2015 International Union of Crystallography. Source

Rutishauser S.,Paul Scherrer Institute | Zanette I.,European Synchrotron Radiation Facility | Weitkamp T.,Synchrotron Soleil | Donath T.,Paul Scherrer Institute | And 2 more authors.
Applied Physics Letters | Year: 2011

We report on the application of a two-dimensional hard x-ray grating interferometer to x-ray optics metrology. The interferometer is sensitive to refraction angles in two perpendicular directions with a precision of 10 nrad. It is used to observe the wavefront changes induced by a single parabolic beryllium focusing lens of large radius of curvature. The lens shape is reconstructed and its residual aberrations are analyzed. Its profile differs from an ideal parabolic shape by less than 2 m or /50 at 0.54 wavelength. © 2011 American Institute of Physics. Source

Rutishauser S.,Paul Scherrer Institute | Donath T.,Paul Scherrer Institute | Donath T.,DECTRIS Ltd. | David C.,Paul Scherrer Institute | And 6 more authors.
Optics Express | Year: 2011

We report on a setup for differential x-ray phase-contrast imaging and tomography, that measures the full 2D phase-gradient information. The setup uses a simple one-dimensional x-ray grating interferometer, in which the grating structures of the interferometer are oriented at a tilt angle wi1th respect to the sample rotation axis. In such a configuration, the differential phase images from opposing tomography projections can be combined to yield both components of the gradient vector. We show how the refractive index distribution as well as its x, y, and z gradient components can be reconstructed directly from the recorded projection data. The method can equally well be applied at conventional x-ray tube sources, to analyzer based x-ray imaging or neutron imaging. It is demonstrated with measurements of an x-ray phantom and a rat brain using synchrotron radiation. © 2011 Optical Society of America. Source

Wright G.S.A.,Institute of Integrative Biology | Lee H.C.,Institute of Integrative Biology | Schulze-Briese C.,DECTRIS Ltd. | Grossmann J.G.,Institute of Integrative Biology | And 2 more authors.
Journal of Synchrotron Radiation | Year: 2013

This study analyses the potential for laboratory-based size-exclusion chromatography (SEC) integrated small-angle X-ray scattering (SAXS) instrumentation to characterize protein complexes. Using a high-brilliance home source in conjunction with a hybrid pixel X-ray detector, the efficacy of SAXS data collection at pertinent protein concentrations and exposure times has been assessed. Scattering data from SOD1 and from the complex of SOD1 with its copper chaperone, using 10 min exposures, provided data quality in the range 0.03 < q < 0.25 Å-1 that was sufficient to accurately assign radius of gyration, maximum dimension and molecular mass. These data demonstrate that a home source with integrated SEC-SAXS technology is feasible and would enable structural biologists studying systems containing transient protein complexes, or proteins prone to aggregation, to make advanced preparations in-house for more effective use of limited synchrotron beam time. © 2013 International Union of Crystallography. Source

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