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PubMed | Leagrave Dental Sedation Clinic, Dental Clinic 15 Naxxar Road, The Royal Hospital for Neuro disability and Deceased
Type: Journal Article | Journal: British dental journal | Year: 2015

An audit of the use of intravenous ketamine for the provision of conscious sedation in paediatric dentistry was carried out over a three-year period. AUDIT DESIGN: In the audit, 3,751 children were treated and an evaluation was carried out for safety and effectiveness of the drug and procedure, the quality of sedation and clinical procedures provided. In addition, the occurrence of any adverse effects and parental satisfaction were noted along with recovery. All children were ASA I and II, with an average age of 7.5 years. Children were referred because of management problems and were assessed to be at the high anxious level of four and five on the Venham scale. A weight related 0.25 mg/kg was initially administered with additional increments of 0.25 mg/kg given if required. The average total dose provided was 0.41 mg/kg.The majority of children (76%) accepted all treatment with no problems, with 19% experiencing a small amount of resistance. Although a range of dental treatment was provided, it was mostly exodontias of carious primary dentition. A 27% response was provided assessing satisfaction which was very favourable. No adverse reactions occurred although the most common postoperative experience was nausea.This audit demonstrated the safety and effectiveness of using intravenous ketamine for paediatric conscious sedation and implications for training and appropriate service delivery were discussed.

PubMed | Thomas Jefferson University, University at Albany, Deceased. and Shriners Hospitals for Children
Type: Journal Article | Journal: The Journal of bone and joint surgery. American volume | Year: 2015

The Cerebral Palsy Computerized Adaptive Test (CP-CAT) is a parent-reported outcomes instrument for measuring lower and upper-extremity function, activity, and global health across impairment levels and a broad age range of children with cerebral palsy (CP). This study was performed to examine whether the Lower Extremity/Mobility (LE) CP-CAT detects change in mobility following orthopaedic surgery in children with CP.This multicenter, longitudinal study involved administration of the LE CP-CAT, the Pediatric Outcomes Data Collection Instrument (PODCI) Transfer/Mobility and Sports/Physical Functioning domains, and the Timed Up & Go test (TUG) before and after elective orthopaedic surgery in a convenience sample of 255 children, four to twenty years of age, who had CP and a Gross Motor Function Classification System (GMFCS) level of I, II, or III. Standardized response means (SRMs) and 95% confidence intervals (CIs) were calculated for all measures at six, twelve, and twenty-four months following surgery.SRM estimates for the LE CP-CAT were significantly greater than the SRM estimates for the PODCI Transfer/Mobility domain at twelve months, the PODCI Sports/Physical Functioning domain at twelve months, and the TUG at twelve and twenty-four months. When the results for the children at GMFCS levels I, II, and III were grouped together, the improvements in function detected by the LE CP-CAT at twelve and twenty-four months were found to be greater than the changes detected by the PODCI Transfer/Mobility and Sports/Physical Functioning scales. The LE CP-CAT outperformed the PODCI scales for GMFCS levels I and III at both of these follow-up intervals; none of the scales performed well for patients with GMFCS level II.The results of this study showed that the LE CP-CAT displayed superior sensitivity to change than the PODCI and TUG scales after musculoskeletal surgery in children with CP.

Harper D.A.T.,Copenhagen University | Alvarez F.,University of Oviedo | Boucoti A.J.,Oregon State University | Williams A.,Deceased | And 2 more authors.
Special Papers in Palaeontology | Year: 2010

The phylogenetic placement of Tropidoleptus, a common and distinctive genus of articulated brachiopod, has proved difficult. Tropidoleptus has, for example, been related to orthides, strophomenides and terebratulides. In the first edition of the Treatise, the genus was assigned to the Enteletoidea, largely on the basis of its general shape and the presence of punctation. The cyrtomatodont dentition, however, and complex cardinalia with crurae, apophyses and a median septum are more typical of some of the more unusual rhynchonellides, for example the Uncinuloidea and more specifically the Eatoniidae. A punctate shell condition, nonetheless, has not been reported in that group. It is argued that Tropidoleptus, although it shares many of its features with a number of rhynchonellate orders, has characteristic and unique features justifying the elevation of the Tropidoleptidae to ordinal status, and cladistic analysis places the new order in a basal position within the Rhynchonellata stemgroup. © The Palaeontological Association.

Bielska K.,U.S. National Institute of Standards and Technology | Bielska K.,Nicolaus Copernicus University | Havey D.K.,Deceased | Scace G.E.,U.S. National Institute of Standards and Technology | And 3 more authors.
Geophysical Research Letters | Year: 2013

The vapor pressure of hexagonal (Ih) water ice was measured over the temperature range 175 K to 253.4 K and referenced to the value at the triple point of water. This experiment combined a highly accurate humidity generation system containing an ice-coated saturator (millikelvin-level temperature control) to provide humidified streams of nitrogen to a cavity-enhanced laser absorption spectrometer. The measured ice vapor pressures had relative standard uncertainties ranging from 0.4% to 0.7% over the entire temperature range. We demonstrate that these measurements validate thermodynamic correlations for ice vapor pressure based on integration of the Clapeyron equation. Moreover, they also indicate that some commonly used vapor pressure correlations are inaccurate and should be avoided. Key Points Widely used ice vapor pressure correlations are empirical and inexact Accurate thermodynamics-based expressions have been validated down to -100 degrees C These expressions can be reliably extrapolated to temperatures as low as 50 K ©2013. American Geophysical Union. All Rights Reserved.

Smithers C.N.,Deceased
Australian Entomologist | Year: 2012

Two direct observations of butterflies at high altitudes in thermals are noted, supporting the hypothesis that long distance migration of butterflies between Australia and New Zealand takes place at high altitudes.

van der Burgt X.M.,Herbarium | Eyakwe M.,Korup P Transect Plots | Motoh J.,Deceased
Kew Bulletin | Year: 2012

Summary: The tree species Gilbertiodendron newberyi Burgt (Leguminosae: Caesalpinioideae) is described and illustrated. The new species is related to G. ogoouense (Pellegr.) J. Léonard s. s. Trees of G. newberyi can grow to 51 m high and 197 cm trunk diam. The new species is ectomycorrhizal, grows gregariously, and presents ballistic seed dispersal. G. newberyi is endemic to Korup National Park in Cameroon, and is assessed as Endangered D under the criteria of IUCN. © 2012 The Board of Trustees of the Royal Botanic Gardens, Kew.

PubMed | Indiana University and Deceased.
Type: Journal Article | Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis | Year: 2015

Polymyxin B is a cationic peptide that inhibits phospholipid-dependent coagulation tests including activated partial thromboplastin time and to a lesser degree prothrombin time. Thrombin clotting time is insensitive to polymyxin B. 2-glycoprotein 1 (2GP1) is a cofactor of antiphospholipid antibodies. Antiphospholipid autoantibodies also poses lupus anticoagulant activity through interactions with 2GP1. Using affinity chromatography, polymyxin B can effectively decrease the binding of 2GP1 to immobilize phosphatidylserine. Since then, anticoagulant effect of polymyxin B is most likely due to the binding to negatively charged phospholipids, preventing formation of coagulation complexes.

PubMed | Khan Research Laboratories and Deceased
Type: Letter | Journal: Zootaxa | Year: 2015

Takereana n. gen. is erected for the New Zealand species, Idotea festiva Chilton, 1885, which is redescribed. Takereana, Austridotea Poore, 2001 and Idotea Fabricius, 1798 are the only idoteid genera in which both pleonites 1 and 2 are truly articulating. In all other genera of Idoteidae pleonite 2 is variously fused to pleonite 1 and visible only laterally. The new genus differs from Austridotea in that maxillipedal palp articles 2-3 and 4-5 are fused and operculate whereas in Austridotea the palp is of five free articles or has only articles 4-5 fused. All species of Austridotea are smooth with laterally expanded coxae, a quite different habitus from ornamented Takereana festiva. Takereana differs from Idotea in having two uropodal rami rather than one, greater fusion of maxillipedal palp articles, lacking spiniform setae on the pereopods, and unusual narrow pleopods 1. Takereana has an obsolete setose mandibular molar while it is columnar and toothed in both these genera.

PubMed | University of Auckland, University of Sydney and Deceased.
Type: Journal Article | Journal: The journal of allergy and clinical immunology. In practice | Year: 2015

Use of electronic monitoring devices (EMDs) for inhalers is growing rapidly because of their ability to provide objective and detailed adherence data to support clinical decision making. There is increasing potential for the use of EMDs in clinical settings, especially as cost-effectiveness is realized and device costs reduce. However, it is important for clinicians to know about the attributes of different EMDs so that they can select the right device for their patients and understand the factors that affect the reliability and accuracy of the data EMDs record. This article gives information on where to obtain EMDs, describes device specifications, and highlights useful features for the clinician and the patient, including user feedback data. We discuss the benefits and potential drawbacks of data collected by EMDs and provide device users with a set of tools to optimize the use of EMDs in clinical settings, such as advice on how to carry out brief EMD checks to ensure data quality and device reliability. New EMDs on the market require pretesting before use by patients. We provide information on how to carry out EMD pretesting in the clinic and patients homes, which can be carried out by health professionals or in collaboration with researchers or manufacturers. Strategies for interpreting and managing common device malfunctions are also discussed.

PubMed | National Health Research Institute, Johns Hopkins University, Tel Aviv University, Deceased. and Biomedical Computer Research Institute
Type: Journal Article | Journal: The Journal of bone and joint surgery. American volume | Year: 2016

Polyostotic fibrous dysplasia is a skeletal disease that results from somatic activating mutations in the gene GNAS in skeletal stem cells, leading to proliferation of immature osteogenic cells with replacement of normal marrow and bone with fibro-osseous tissue. Lesions may cause bone deformity or fracture. In the surgical care of polyostotic fibrous dysplasia, the role of grafting and the optimal grafting material are not clear. The purpose of this study was to evaluate the long-term survival of bone-grafting procedures in subjects with polyostotic fibrous dysplasia over time.The operative reports and radiographs of a cohort of subjects with polyostotic fibrous dysplasia followed in a natural history study were reviewed. Twenty-three subjects (mean age at the time of enrollment, thirteen years [range, two to forty years]) with fifty-two bone-grafting procedures had a mean follow-up time of 19.6 years (range, twenty-nine months to forty-seven years). Kaplan-Meier life table estimates, Cox proportional hazard models, and t tests comparing means were performed to assess various aspects of graft survival.Kaplan-Meier curves showed a 50% estimate of survival of 14.5 years. Cox proportional hazards models showed no advantage comparing allograft with autograft or structural with nonstructural graft materials. The mean age of the patients was significantly greater (p < 0.001) in the subgroup of subjects in whom grafts were maintained over time (20.9 years) compared with the subgroup of patients whose grafts were resorbed over time (9.8 years).Bone-grafting, including both allograft and autograft, is of limited value in ablating the lesions of fibrous dysplasia. The expectations of patients and surgeons should include the high probability of graft resorption over time with return of bone characteristics of fibrous dysplasia, particularly in younger patients. This suggests the maintenance of normal bone mechanics with implant support should be the priority of any surgical intervention.

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